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Sci. Pharm.
Volume 76
Issue 3
10.3797/scipharm.0804-17
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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
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Article

Development and Validation of a Dissolution Method with Spectrophotometric Analysis for Diacerhein Capsules

by
Sílvia H. M. BORGMANN
1,
Lutiane PARCIANELLO
2,
Marcela Z. AREND
2,
Liziane BAJERSKI
2 and
Simone G. CARDOSO
1,*
1
Departamento de Ciências Farmarcêuticas, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil
2
Departamento de Farmácia Industrial, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2008, 76(3), 541-554; https://doi.org/10.3797/scipharm.0804-17
Submission received: 16 April 2008 / Accepted: 31 July 2008 / Published: 9 August 2008
Versions Notes

Abstract

The aim of this work was to develop and validate a dissolution test for diacerhein in capsules using spectrophotometric method. The dissolution established conditions were: 900 mL of sodium phosphate buffer pH 7.0 with 0.75 % of sodium lauryl sulphate as dissolution medium, using a basket apparatus at a stirring rate of 50 rpm. The drug release was evaluated by UV spectrophotometric method at 258 nm. The method was validated to meet requirements for a global regulatory filing. The validation included specificity, linearity, precision and accuracy. In addition, filter suitability and drug stability in medium were demonstrated. The comparison of the obtained dissolution profiles of capsules, obtained from three different brands (denominate product A, B and C) of 50 mg diacerhein, was performed and the results showed no significative difference among the products.
Keywords: Dissolution; Validation; Diacerhein capsules Dissolution; Validation; Diacerhein capsules

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MDPI and ACS Style

BORGMANN, S.H.M.; PARCIANELLO, L.; AREND, M.Z.; BAJERSKI, L.; CARDOSO, S.G. Development and Validation of a Dissolution Method with Spectrophotometric Analysis for Diacerhein Capsules. Sci. Pharm. 2008, 76, 541-554. https://doi.org/10.3797/scipharm.0804-17

AMA Style

BORGMANN SHM, PARCIANELLO L, AREND MZ, BAJERSKI L, CARDOSO SG. Development and Validation of a Dissolution Method with Spectrophotometric Analysis for Diacerhein Capsules. Scientia Pharmaceutica. 2008; 76(3):541-554. https://doi.org/10.3797/scipharm.0804-17

Chicago/Turabian Style

BORGMANN, Sílvia H. M., Lutiane PARCIANELLO, Marcela Z. AREND, Liziane BAJERSKI, and Simone G. CARDOSO. 2008. "Development and Validation of a Dissolution Method with Spectrophotometric Analysis for Diacerhein Capsules" Scientia Pharmaceutica 76, no. 3: 541-554. https://doi.org/10.3797/scipharm.0804-17

APA Style

BORGMANN, S. H. M., PARCIANELLO, L., AREND, M. Z., BAJERSKI, L., & CARDOSO, S. G. (2008). Development and Validation of a Dissolution Method with Spectrophotometric Analysis for Diacerhein Capsules. Scientia Pharmaceutica, 76(3), 541-554. https://doi.org/10.3797/scipharm.0804-17

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