Abbauprodukte von Amiloridhydrochlorid

Klaus Görlitzer; Silke Huth; Edith Gößnitzer; Winfried Wendelin

doi:10.3797/scipharm.aut-04-10

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Article

1 June 2004

Abbauprodukte von Amiloridhydrochlorid

and

Institut für Pharmazeutische Chemie der Technischen Universität Braunschweig, Beethovenstraße 55, D-38106 Braunschweig, Germany

Institut für Pharmazeutische Chemie und Pharmazeutische Technologie der Karl-Franzens-Universität Graz, Schubertstraße 1, A-8010 Graz, Austria

Author to whom correspondence should be addressed.

Sci. Pharm.2004, 72(2), 109-120;https://doi.org/10.3797/scipharm.aut-04-10

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Abstract

Erhitzen von Amiloridhydrochlorid (1 • Hcl) in Acetatpuffer pH 4.6 führte zu Amiloridacetat (1 • AcOH), dem Pyrazindiamin 6 und dem Acylureid 7. Das Pteridinon 3 wurde beim Erhitzen von 1 • Hcl in DMF unter Rückfluß erhalten.

Keywords:

Amiloridhydrochlorid; Abbauprodukte; 6-Chlor-2,7-diamino-4(3H)-Pteridinone

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