Synthesis of new piperidine and cyclohexylamino-spiro derivatives as potential anticalcium agents

Sánchez Isabel; Pujol Maria Dolors; Guillaumet Gérald; Massingham Roy; Monteil André

doi:10.3797/scipharm.aut-02-19

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Article

4 June 2002

Synthesis of new piperidine and cyclohexylamino-spiro derivatives as potential anticalcium agents

and

Laboratori de Quimica Farmaceutica, Facultat de Farmacia, Universitat de Barcelona, Av. Diagonal 643, 08028 Barcelona (Spain)

lnstitut de Chimie Organique et Analytique associe au CNRS, Universite d'orleans, BP 6957,45067 Orleans Cedex 2 (France).

UCB Pharma, Pharmaceutical Sector, Chemin du Foriest, B-1420 Braine-L'Alleud (Belgique)

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Laboratoire RL-CERM, ZI La Varenne, rue H. Goudier, 63203 Riom, Cedex (France)

Sci. Pharm.2002, 70(2), 177-185;https://doi.org/10.3797/scipharm.aut-02-19

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Simple Summary

The synthesis of new 1,3-benzodioxolo and 1,4- benzodioxan spiro derivatives containing a piperidine (4-6) or cyclohexylamino (7-8) group have been described. These compounds exhibit in vitro a moderate anticalcium activity.

Excerpt

Note: In lieu of an abstract, this is an excerpt from the first page.

The spiropiperidine derivatives have considerable importance in pharmaceutical chemistry due to their effects on different biological systems [...]

Keywords:

Spiro compounds, 1,3-benzodioxole, 1,3-benzodioxan, anticalcium activity

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