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Diseases, Volume 9, Issue 3

2021 September - 20 articles

Cover Story: In this study, the unsupervised machine learning consensus clustering algorithm identified a total of three unique patient clusters of hyponatremia based on demographic information, principal diagnoses, comorbidities, and laboratory data. The three clusters represented clinically distinct subgroups derived from multidimensional baseline data, and carried different mortality risk. View this paper
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Articles (20)

  • Communication
  • Open Access
12 Citations
5,500 Views
7 Pages

Melatonin as an Add-On Treatment of COVID-19 Infection: Current Status

  • Gregory M. Brown,
  • Seithikurippu R. Pandi-Perumal,
  • Harold Pupko,
  • James L. Kennedy and
  • Daniel P. Cardinali

20 September 2021

This brief review was written to provide a perspective on the flurry of reports suggesting that melatonin can be an important add-on therapy for COVID-19. Despite the passage of more than 60 years since its discovery and much evidence representing th...

  • Interesting Images
  • Open Access
1 Citations
3,533 Views
6 Pages

Papillary Meningioma: Case Presentation with Emphasis on Surgical and Medical Therapy of a Rare Variant of Meningioma

  • Gerardo Cazzato,
  • Valeria Internò,
  • Antonietta Cimmino,
  • Raffaella Messina,
  • Marco Tucci,
  • Teresa Lettini,
  • Leonardo Resta and
  • Giuseppe Ingravallo

17 September 2021

Meningioma is one of the most frequent neoplasms of all in the central nervous system. Different variants are known, and of these some have peculiar characteristics, both from a morphological point of view and from a biological point of view. Here, w...

  • Article
  • Open Access
17 Citations
14,634 Views
12 Pages

17 September 2021

To examine the association between uric acid levels and liver enzyme functions amongst adults with hyperuricemia and gout in the United States. The National Health and Nutrition Examination Survey (NHANES) data from 2007 to 2016 was used to study the...

  • Case Report
  • Open Access
2,192 Views
4 Pages

A Curve Maybe to Narrow: Description of an Anomalous Course of the Right Coronary Artery

  • Guido Pastorini,
  • Elisa Bertone,
  • Alberto Talenti and
  • Mauro Feola

17 September 2021

Congenital coronary artery anomalies are rare but well-described causes of chest pain and, in some cases, link to sudden cardiac death. With the spread of advanced imaging techniques, the number of incidental findings is staggering, but little inform...

  • Review
  • Open Access
28 Citations
7,715 Views
25 Pages

Novel Insights into the Role of Probiotics in Respiratory Infections, Allergies, Cancer, and Neurological Abnormalities

  • Igori Balta,
  • Eugenia Butucel,
  • Valentyn Mohylyuk,
  • Adriana Criste,
  • Daniel Severus Dezmirean,
  • Lavinia Stef,
  • Ioan Pet and
  • Nicolae Corcionivoschi

2 September 2021

In recent years, probiotics have attracted public attention and transformed the social perception of microorganisms, convening a beneficial role/state on human health. With aging, the immune system, body physiology, and intestinal microbiota tend to...

  • Article
  • Open Access
9 Citations
7,214 Views
11 Pages

Efficacy of Urine Dipstick Test in Diagnosing Urinary Tract Infection and Detection of the blaCTX-M Gene among ESBL-Producing Escherichia coli

  • Rubina Gurung,
  • Sanjib Adhikari,
  • Nabaraj Adhikari,
  • Sanjeep Sapkota,
  • Jid Chani Rana,
  • Binod Dhungel,
  • Upendra Thapa Shrestha,
  • Megha Raj Banjara,
  • Prakash Ghimire and
  • Komal Raj Rijal

27 August 2021

A urine dipstick test used for prompt diagnosis of urinary tract infection (UTI) is a rapid and cost-effective method. The main objective of this study was to compare the efficacy of the urine dipstick test with culture methods in screening for UTIs...

  • Brief Report
  • Open Access
9 Citations
3,715 Views
6 Pages

Skin Adverse Reactions to Novel Messenger RNA Coronavirus Vaccination: A Case Series

  • Maria Francesca Peigottu,
  • Caterina Ferreli,
  • Maria Giovanna Atzori and
  • Laura Atzori

27 August 2021

Vaccines are actually the most effective strategy to control the COVID-19 spread and reduce mortality, but adverse reactions can occur. Skin involvement with novel messenger RNA coronavirus vaccines seems frequent but is not completely characterized....

  • Review
  • Open Access
7 Citations
17,734 Views
19 Pages

Synthetic mRNAs; Their Analogue Caps and Contribution to Disease

  • Anthony M. Kyriakopoulos and
  • Peter A. McCullough

23 August 2021

The structure of synthetic mRNAs as used in vaccination against cancer and infectious diseases contain specifically designed caps followed by sequences of the 5′ untranslated repeats of β-globin gene. The strategy for successful design of synthetic m...

  • Case Report
  • Open Access
3,269 Views
7 Pages

Cesarean Hysterectomy in Abnormally Invasive Placenta: The Role of Prenatal Diagnosis

  • Ana Maria Cubo,
  • Ana Villalba Yarza,
  • Irene Gastaca,
  • María Victoria Lapresa-Alcalde,
  • Maria José Doyague,
  • Cristina Gónzalez and
  • José María Sayagués

17 August 2021

An abnormally invasive placenta (AIP) is a placenta that cannot be removed spontaneously or manually without causing severe bleeding. It is a dangerous condition associated with a high rate of maternal and perinatal morbidity and mortality due to the...

  • Review
  • Open Access
7 Citations
4,965 Views
11 Pages

Precision Medicine and Adverse Drug Reactions Related to Cardiovascular Drugs

  • James D. Noyes,
  • Ify R. Mordi,
  • Alexander S. Doney,
  • Rahman Jamal and
  • Chim C. Lang

12 August 2021

Cardiovascular disease remains the leading global cause of death. Early intervention, with lifestyle advice alongside appropriate medical therapies, is fundamental to reduce patient mortality among high-risk individuals. For those who live with the d...

  • Article
  • Open Access
9 Citations
5,197 Views
9 Pages

Machine Learning Consensus Clustering of Hospitalized Patients with Admission Hyponatremia

  • Charat Thongprayoon,
  • Panupong Hansrivijit,
  • Michael A. Mao,
  • Pradeep K. Vaitla,
  • Andrea G. Kattah,
  • Pattharawin Pattharanitima,
  • Saraschandra Vallabhajosyula,
  • Voravech Nissaisorakarn,
  • Tananchai Petnak and
  • Wisit Cheungpasitporn
  • + 4 authors

Background: The objective of this study was to characterize patients with hyponatremia at hospital admission into clusters using an unsupervised machine learning approach, and to evaluate the short- and long-term mortality risk among these distinct c...

  • Review
  • Open Access
12 Citations
4,619 Views
17 Pages

Frailty is a geriatric syndrome characterized by a decrease in physiological reserve and reduced resistance to stress, as a result of an accumulation of multiple deficits in physiological systems. Frailty increases the vulnerability to adverse events...

  • Review
  • Open Access
11 Citations
8,787 Views
12 Pages

Treating Postpartum Depression: What Do We Know about Brexanolone?

  • Muneeza Ali,
  • Alifiya Aamir,
  • Mufaddal Najmuddin Diwan,
  • Hashir Ali Awan,
  • Irfan Ullah,
  • Muhammad Irfan and
  • Domenico De Berardis

Postpartum depression (PPD) is defined as the onset of major depressive disorder in mothers, occurring during pregnancy or within 4 weeks post-delivery. With 7% of pregnancy-related death in the United States owing to mental health conditions, includ...

  • Commentary
  • Open Access
5 Citations
2,797 Views
7 Pages

This study was a sub-analysis of 20 consecutive elderly participants who underwent outpatient rehabilitation at a geriatric health services facility from January 2020 to the end of May 2020, based on our previous report. This study aimed to evaluate...

  • Article
  • Open Access
4 Citations
3,244 Views
8 Pages

Clinical Significance of B-Type Natriuretic Peptide Levels at 3 Months after Atrial Fibrillation Ablation

  • Sen Matsumoto,
  • Yasuharu Matsunaga-Lee,
  • Masashi Ishimi,
  • Mamoru Ohnishi,
  • Nobutaka Masunaga,
  • Koichi Tachibana and
  • Yuzuru Takano

The role of B-type natriuretic peptide (BNP) levels as a predictor of arrhythmia recurrence (AR) after atrial fibrillation (AF) ablation remains unclear. In this study, we investigated the association of BNP levels before and 3 months after ablation...

  • Review
  • Open Access
33 Citations
7,964 Views
24 Pages

Abnormal Liver Biochemistry Tests and Acute Liver Injury in COVID-19 Patients: Current Evidence and Potential Pathogenesis

  • Donovan A. McGrowder,
  • Fabian Miller,
  • Melisa Anderson Cross,
  • Lennox Anderson-Jackson,
  • Sophia Bryan and
  • Lowell Dilworth

Globally, millions of persons have contracted the coronavirus disease 2019 (COVID-19) over the past several months, resulting in significant mortality. Health care systems are negatively impacted including the care of individuals with cancers and oth...

  • Review
  • Open Access
66 Citations
11,514 Views
13 Pages

COVID-19-Associated Cardiovascular Complications

  • Clement C. E. Lee,
  • Kashan Ali,
  • David Connell,
  • Ify R. Mordi,
  • Jacob George,
  • Elizabeth MSL Lang and
  • Chim C. Lang

Coronavirus disease 2019 (COVID-19) has been reported to cause cardiovascular complications such as myocardial injury, thromboembolic events, arrhythmia, and heart failure. Multiple mechanisms—some overlapping, notably the role of inflammation and IL...

  • Review
  • Open Access
13 Citations
5,443 Views
9 Pages

Emerging Role of Epigenetics in Explaining Relationship of Periodontitis and Cardiovascular Diseases

  • Syed Ameer Hamza,
  • Saba Asif,
  • Zohaib Khurshid,
  • Muhammad Sohail Zafar and
  • Syed Akhtar Hussain Bokhari

Cardiovascular diseases such as ischemic heart diseases or stroke are among the leading cause of deaths globally, and evidence suggests that these diseases are modulated by a multifactorial and complex interplay of genetic, environmental, and lifesty...

  • Review
  • Open Access
10 Citations
5,450 Views
10 Pages

The Potential Use of Vitamin C to Prevent Kidney Injury in Patients with COVID-19

  • Feng Xu,
  • Yawei Wen,
  • Xinge Hu,
  • Tiannan Wang and
  • Guoxun Chen

The newly found SARS-CoV-2 has led to the pandemic of COVID-19, which has caused respiratory distress syndrome and even death worldwide. This has become a global public health crisis. Unfortunately, elders and subjects with comorbidities have high mo...

  • Review
  • Open Access
66 Citations
8,979 Views
18 Pages

Current research in medicine in several parts of the world has attempted to establish a link between the occurrence of neurodegenerative pathologies, microbiota dysbiosis, and the incidence of obesity. The body’s response to different physicochemical...

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Diseases - ISSN 2079-9721