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Fibers 2015, 3(3), 253-264;

Investigating the Influence of Extracellular Matrix and Glycolytic Metabolism on Muscle Stem Cell Migration on Their Native Fiber Environment

School of Biological Sciences, University of Reading, Reading RG6 6UB, UK
Department of Agricultural, Food and Environmental Sciences, University of Perugia, Perugia I-06121, Italy
Department of Cell and Molecular Biology, Scripps Research Institute, La Jolla, CA 92037, USA
Author to whom correspondence should be addressed.
Academic Editor: Jingwei Xie
Received: 2 June 2015 / Accepted: 8 July 2015 / Published: 16 July 2015
(This article belongs to the Special Issue Fibers for Biomedical Applications)
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The composition of the extracellular matrix (ECM) of skeletal muscle fibers is a unique environment that supports the regenerative capacity of satellite cells; the resident stem cell population. The impact of environment has great bearing on key properties permitting satellite cells to carry out tissue repair. In this study, we have investigated the influence of the ECM and glycolytic metabolism on satellite cell emergence and migration—two early processes required for muscle repair. Our results show that both influence the rate at which satellite cells emerge from the sub-basal lamina position and their rate of migration. These studies highlight the necessity of performing analysis of satellite behavior on their native substrate and will inform on the production of artificial scaffolds intended for medical uses. View Full-Text
Keywords: muscle; fiber; satellite; blebbing; myostatin; migration muscle; fiber; satellite; blebbing; myostatin; migration

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Butera, G.; Collins-Hooper, H.; Mitchell, R.; Makarenkova, H.P.; Lasagna, E.; Patel, K. Investigating the Influence of Extracellular Matrix and Glycolytic Metabolism on Muscle Stem Cell Migration on Their Native Fiber Environment. Fibers 2015, 3, 253-264.

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