Table of Contents
Biosensors, Volume 9, Issue 2 (June 2019)
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Cover Story (view full-size image) Melanoma is an aggressive cancer with a high propensity to metastasize to the brain. However, this [...] Read more. Melanoma is an aggressive cancer with a high propensity to metastasize to the brain. However, this requires the disruption of junctional complexes present at the blood–brain barrier (BBB), which restricts the passage of blood-borne pathogens into the brain, protecting it from injury. Brain endothelial cells are a key component of the BBB and form the first line of defence against circulating molecules (or melanoma cells). Therefore, we investigated the barrier integrity of brain endothelial cells when testing melanoma cell invasion and migration. The research aims were to investigate the ability of human melanoma cells to affect barrier strength of human brain-derived endothelial cells using a sensitive, real-time, and label-free measure of electrical resistance. The research hypothesis was that melanoma cells would disrupt the blood–endothelial barrier. View this paper.