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Biosensors, Volume 9, Issue 2

June 2019 - 35 articles

Cover Story: Melanoma is an aggressive cancer with a high propensity to metastasize to the brain. However, this requires the disruption of junctional complexes present at the blood–brain barrier (BBB), which restricts the passage of blood-borne pathogens into the brain, protecting it from injury. Brain endothelial cells are a key component of the BBB and form the first line of defence against circulating molecules (or melanoma cells). Therefore, we investigated the barrier integrity of brain endothelial cells when testing melanoma cell invasion and migration. The research aims were to investigate the ability of human melanoma cells to affect barrier strength of human brain-derived endothelial cells using a sensitive, real-time, and label-free measure of electrical resistance. The research hypothesis was that melanoma cells would disrupt the blood–endothelial barrier. View this paper.
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Articles (35)

  • Article
  • Open Access
31 Citations
7,470 Views
10 Pages

Biological Effects of C60 Fullerene Revealed with Bacterial Biosensor—Toxic or Rather Antioxidant?

  • Sergey Emelyantsev,
  • Evgeniya Prazdnova,
  • Vladimir Chistyakov and
  • Igor Alperovich

21 June 2019

Nanoparticles have been attracting growing interest for both their antioxidant and toxic effects. Their exact action on cells strongly depends on many factors, including experimental conditions, preparation, and solvents used, which have contributed...

  • Review
  • Open Access
25 Citations
7,737 Views
14 Pages

20 June 2019

The chemical, temporal, and spatial resolution of chemical signals that are sampled and transported with continuous flow is limited because of Taylor dispersion. Droplets have been used to solve this problem by digitizing chemical signals into discre...

  • Article
  • Open Access
25 Citations
7,565 Views
12 Pages

Noncompetitive Chromogenic Lateral-Flow Immunoassay for Simultaneous Detection of Microcystins and Nodularin

  • Sultana Akter,
  • Teemu Kustila,
  • Janne Leivo,
  • Gangatharan Muralitharan,
  • Markus Vehniäinen and
  • Urpo Lamminmäki

18 June 2019

Cyanobacterial blooms cause local and global health issues by contaminating surface waters. Microcystins and nodularins are cyclic cyanobacterial peptide toxins comprising numerous natural variants. Most of them are potent hepatotoxins, tumor promote...

  • Review
  • Open Access
398 Citations
26,574 Views
39 Pages

Silver-Based Plasmonic Nanoparticles for and Their Use in Biosensing

  • Alexis Loiseau,
  • Victoire Asila,
  • Gabriel Boitel-Aullen,
  • Mylan Lam,
  • Michèle Salmain and
  • Souhir Boujday

10 June 2019

The localized surface plasmon resonance (LSPR) property of metallic nanoparticles is widely exploited for chemical and biological sensing. Selective biosensing of molecules using functionalized nanoparticles has become a major research interdisciplin...

  • Article
  • Open Access
12 Citations
7,214 Views
17 Pages

Towards CMOS Integrated Microfluidics Using Dielectrophoretic Immobilization

  • Honeyeh Matbaechi Ettehad,
  • Rahul Kumar Yadav,
  • Subhajit Guha and
  • Christian Wenger

Dielectrophoresis (DEP) is a nondestructive and noninvasive method which is favorable for point-of-care medical diagnostic tests. This technique exhibits prominent relevance in a wide range of medical applications wherein the miniaturized platform fo...

  • Review
  • Open Access
42 Citations
13,312 Views
35 Pages

In Vivo Biosensing Using Resonance Energy Transfer

  • Shashi Bhuckory,
  • Joshua C. Kays and
  • Allison M. Dennis

Solution-phase and intracellular biosensing has substantially enhanced our understanding of molecular processes foundational to biology and pathology. Optical methods are favored because of the low cost of probes and instrumentation. While chromatogr...

  • Review
  • Open Access
44 Citations
9,161 Views
19 Pages

Since electronic noses are used more and more for air quality monitoring purposes, and in some countries are starting to have a legal value, there is a need for standardization and programs for the quality verification of instruments. Such quality pr...

  • Article
  • Open Access
37 Citations
8,805 Views
9 Pages

Graphene Oxide-Based Nanostructured DNA Sensor

  • Aditya Balaji,
  • Songlin Yang,
  • Jeslyn Wang and
  • Jin Zhang

Quick detection of DNA sequence is vital for many fields, especially, early-stage diagnosis. Here, we develop a graphene oxide-based fluorescence quenching sensor to quickly and accurately detect small amounts of a single strand of DNA. In this paper...

  • Article
  • Open Access
12 Citations
7,445 Views
14 Pages

Acoustofluidic Micromixing Enabled Hybrid Integrated Colorimetric Sensing, for Rapid Point-of-Care Measurement of Salivary Potassium

  • Vikram Surendran,
  • Thomas Chiulli,
  • Swetha Manoharan,
  • Stephen Knisley,
  • Muthukumaran Packirisamy and
  • Arvind Chandrasekaran

The integration of microfluidics with advanced biosensor technologies offers tremendous advantages such as smaller sample volume requirement and precise handling of samples and reagents, for developing affordable point-of-care testing methodologies t...

  • Article
  • Open Access
19 Citations
8,974 Views
13 Pages

Casein-Conjugated Gold Nanoparticles for Amperometric Detection of Leishmania infantum

  • Mohamed Fethi Diouani,
  • Oussama Ouerghi,
  • Kamel Belgacem,
  • Maher Sayhi,
  • Radu Ionescu and
  • Dhafer Laouini

Sensitive and reliable approaches targeting the detection of Leishmania are critical for effective early diagnosis and treatment of leishmaniasis. In this frame, this paper describes a rapid quantification assay to detect Leishmania parasites based o...

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Biosensors - ISSN 2079-6374