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Open AccessArticle

Acoustofluidic Micromixing Enabled Hybrid Integrated Colorimetric Sensing, for Rapid Point-of-Care Measurement of Salivary Potassium

1
Department of Chemical, Biological and Bio Engineering, North Carolina A & T State University, Greensboro, NC 27411, USA
2
Department of Mechanical, Industrial and Aerospace Engineering, Concordia University, Montreal, QC H2L5C9, Canada
*
Author to whom correspondence should be addressed.
Biosensors 2019, 9(2), 73; https://doi.org/10.3390/bios9020073
Received: 22 April 2019 / Revised: 16 May 2019 / Accepted: 24 May 2019 / Published: 28 May 2019
(This article belongs to the Special Issue Microfluidics for Biosensing and Diagnostics)
The integration of microfluidics with advanced biosensor technologies offers tremendous advantages such as smaller sample volume requirement and precise handling of samples and reagents, for developing affordable point-of-care testing methodologies that could be used in hospitals for monitoring patients. However, the success and popularity of point-of-care diagnosis lies with the generation of instantaneous and reliable results through in situ tests conducted in a painless, non-invasive manner. This work presents the development of a simple, hybrid integrated optical microfluidic biosensor for rapid detection of analytes in test samples. The proposed biosensor works on the principle of colorimetric optical absorption, wherein samples mixed with suitable chromogenic substrates induce a color change dependent upon the analyte concentration that could then be detected by the absorbance of light in its path length. This optical detection scheme has been hybrid integrated with an acoustofluidic micromixing unit to enable uniform mixing of fluids within the device. As a proof-of-concept, we have demonstrated the real-time application of our biosensor format for the detection of potassium in whole saliva samples. The results show that our lab-on-a-chip technology could provide a useful strategy in biomedical diagnoses for rapid analyte detection towards clinical point-of-care testing applications. View Full-Text
Keywords: point-of-care; biosensor; hybrid integration; microfluidics; acoustofluidics; cavitation; micromixing; optical absorbance; colorimetry; salivary potassium point-of-care; biosensor; hybrid integration; microfluidics; acoustofluidics; cavitation; micromixing; optical absorbance; colorimetry; salivary potassium
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Surendran, V.; Chiulli, T.; Manoharan, S.; Knisley, S.; Packirisamy, M.; Chandrasekaran, A. Acoustofluidic Micromixing Enabled Hybrid Integrated Colorimetric Sensing, for Rapid Point-of-Care Measurement of Salivary Potassium. Biosensors 2019, 9, 73.

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