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Biosensors, Volume 11, Issue 4

2021 April - 32 articles

Cover Story: Selenium (Se) is an essential micronutrient which has antioxidant properties and is known to play a role in cancer prevention. Green algae Chlorella vulgaris cultivated in Se-enriched environment may be used as a food supplement to provide adequate levels of Se. We used Raman microspectroscopy (RS) for fast and nondestructive measurement of Se concentration in algal cells. We employed inductively coupled plasma mass spectrometry as a reference method for RS and found a solid correlation between the Raman signal intensity at 252 cm−1 and total Se concentration in the studied cells. We used RS to demonstrated the necessity of active cellular transport for Se accumulation. Additionally, we observed the intracellular Se being transformed into an elemental form, which we further supported using energy-dispersive X-ray spectroscopy imaging. View this paper.
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Articles (32)

  • Article
  • Open Access
23 Citations
5,048 Views
14 Pages

Cross-Domain Transfer Learning for PCG Diagnosis Algorithm

  • Kuo-Kun Tseng,
  • Chao Wang,
  • Yu-Feng Huang,
  • Guan-Rong Chen,
  • Kai-Leung Yung and
  • Wai-Hung Ip

20 April 2021

Cardiechema is a way to reflect cardiovascular disease where the doctor uses a stethoscope to help determine the heart condition with a sound map. In this paper, phonocardiogram (PCG) is used as a diagnostic signal, and a deep learning diagnostic fra...

  • Review
  • Open Access
261 Citations
22,765 Views
36 Pages

Sources of Inaccuracy in Photoplethysmography for Continuous Cardiovascular Monitoring

  • Jesse Fine,
  • Kimberly L. Branan,
  • Andres J. Rodriguez,
  • Tananant Boonya-ananta,
  • Ajmal,
  • Jessica C. Ramella-Roman,
  • Michael J. McShane and
  • Gerard L. Coté

16 April 2021

Photoplethysmography (PPG) is a low-cost, noninvasive optical technique that uses change in light transmission with changes in blood volume within tissue to provide information for cardiovascular health and fitness. As remote health and wearable medi...

  • Communication
  • Open Access
6 Citations
3,211 Views
9 Pages

A Theoretical and Simulation Analysis of the Sensitivity of SiNWs-FET Sensors

  • Yi Yang,
  • Zicheng Lu,
  • Duo Liu,
  • Yuelin Wang,
  • Shixing Chen and
  • Tie Li

15 April 2021

Theoretical study and software simulation on the sensitivity of silicon nanowires (SiNWs) field effect transistor (FET) sensors in terms of surface-to-volume ratio, depletion ratio, surface state and lattice quality are carried out. Generally, SiNWs-...

  • Communication
  • Open Access
25 Citations
3,149 Views
12 Pages

15 April 2021

Organotrialkoxysilanes like 3-aminopropyltrimethoxysilane (3-APTMS)-treated noble metal cations were rapidly converted into their respective nanoparticles in the presence of 3-glycidoxypropylytrimethoxysilane (3-GPTMS). The micellar activity of 3-APT...

  • Review
  • Open Access
48 Citations
10,638 Views
23 Pages

15 April 2021

The rapid spread of epidemic diseases (i.e., coronavirus disease 2019 (COVID-19)) has contributed to focus global attention on the diagnosis of medical conditions by ultrasensitive detection methods. To overcome this challenge, increasing efforts hav...

  • Article
  • Open Access
15 Citations
5,276 Views
24 Pages

Bacteriophage-Based Biosensing of Pseudomonas aeruginosa: An Integrated Approach for the Putative Real-Time Detection of Multi-Drug-Resistant Strains

  • Liliam K. Harada,
  • Waldemar Bonventi Júnior,
  • Erica C. Silva,
  • Thais J. Oliveira,
  • Fernanda C. Moreli,
  • José M. Oliveira Júnior,
  • Matthieu Tubino,
  • Marta M. D. C. Vila and
  • Victor M. Balcão

15 April 2021

During the last decennium, it has become widely accepted that ubiquitous bacterial viruses, or bacteriophages, exert enormous influences on our planet’s biosphere, killing between 4–50% of the daily produced bacteria and constituting the largest gene...

  • Article
  • Open Access
8 Citations
3,657 Views
10 Pages

Rapid Molecular Diagnostic Sensor Based on Ball-Lensed Optical Fibers

  • Byungjun Park,
  • Bonhan Koo,
  • Jisub Kim,
  • Kiri Lee,
  • Hyeonjin Bang,
  • Sung-Han Kim,
  • Kyung Young Jhang,
  • Yong Shin and
  • Seungrag Lee

15 April 2021

Given the fatal health conditions caused by emerging infectious pathogens, such as severe acute respiratory syndrome coronavirus 2, their rapid diagnosis is required for preventing secondary infections and guiding correct treatments. Although various...

  • Article
  • Open Access
42 Citations
6,140 Views
13 Pages

13 April 2021

According to the WTO, there were 1.13 billion hypertension patients worldwide in 2015. The WTO encouraged people to check the blood pressure regularly because a large amount of patients do not have any symptoms. However, traditional cuff measurement...

  • Article
  • Open Access
16 Citations
5,184 Views
11 Pages

A Carbon-Based Antifouling Nano-Biosensing Interface for Label-Free POCT of HbA1c

  • Zhenhua Li,
  • Jianyong Li,
  • Yanzhi Dou,
  • Lihua Wang and
  • Shiping Song

12 April 2021

Electrochemical biosensing relies on electron transport on electrode surfaces. However, electrode inactivation and biofouling caused by a complex biological sample severely decrease the efficiency of electron transfer and the specificity of biosensin...

  • Article
  • Open Access
10 Citations
3,923 Views
12 Pages

Detection of Influenza Virus Using a SOI-Nanoribbon Chip, Based on an N-Type Field-Effect Transistor

  • Kristina A. Malsagova,
  • Tatyana O. Pleshakova,
  • Andrey F. Kozlov,
  • Rafael A. Galiullin,
  • Vladimir P. Popov,
  • Fedor V. Tikhonenko,
  • Alexander V. Glukhov,
  • Vadim S. Ziborov,
  • Ivan D. Shumov and
  • Yuri D. Ivanov
  • + 12 authors

12 April 2021

The detection of influenza A virions with a nanoribbon detector (NR detector) has been demonstrated. Chips for the detector have been fabricated based on silicon-on-insulator nanoribbon structures (SOI nanoribbon chip), using a complementary metal-ox...

  • Perspective
  • Open Access
21 Citations
7,673 Views
14 Pages

11 April 2021

Genetically encoded fluorescent indicators, combined with optical imaging, enable the detection of physiologically or behaviorally relevant neural activity with high spatiotemporal resolution. Recent developments in protein engineering and screening...

  • Article
  • Open Access
16 Citations
4,648 Views
17 Pages

Detection of Sub-Nanomolar Concentration of Trypsin by Thickness-Shear Mode Acoustic Biosensor and Spectrophotometry

  • Ivan Piovarci,
  • Sopio Melikishvili,
  • Marek Tatarko,
  • Tibor Hianik and
  • Michael Thompson

11 April 2021

The determination of protease activity is very important for disease diagnosis, drug development, and quality and safety assurance for dairy products. Therefore, the development of low-cost and sensitive methods for assessing protease activity is cru...

  • Article
  • Open Access
8 Citations
5,619 Views
13 Pages

Raman Microspectroscopic Analysis of Selenium Bioaccumulation by Green Alga Chlorella vulgaris

  • Martin Kizovský,
  • Zdeněk Pilát,
  • Mykola Mylenko,
  • Pavel Hrouzek,
  • Jan Kuta,
  • Radim Skoupý,
  • Vladislav Krzyžánek,
  • Kamila Hrubanová,
  • Olga Adamczyk and
  • Pavel Zemánek
  • + 6 authors

10 April 2021

Selenium (Se) is an element with many commercial applications as well as an essential micronutrient. Dietary Se has antioxidant properties and it is known to play a role in cancer prevention. However, the general population often suffers from Se defi...

  • Article
  • Open Access
11 Citations
5,247 Views
15 Pages

9 April 2021

Blood coagulation is a defense mechanism, which is activated in case of blood loss, due to vessel damage, or other injury. Pathological cases arise from malfunctions of the blood coagulation mechanism, and rapid growth of clots results in partially o...

  • Article
  • Open Access
54 Citations
5,872 Views
11 Pages

9 April 2021

Sensing targeted tumor markers with high sensitivity provides vital information for the fast diagnosis and treatment of cancer patients. A vascular endothelial growth factor (VEGF165) have recently emerged as a promising biomarker of tumor cells. The...

  • Article
  • Open Access
8 Citations
4,083 Views
14 Pages

Melting Curve Analysis of Aptachains: Adenosine Detection with Internal Calibration

  • Chenze Lu,
  • Christine Saint-Pierre,
  • Didier Gasparutto,
  • Yoann Roupioz,
  • Corinne Ravelet,
  • Eric Peyrin and
  • Arnaud Buhot

8 April 2021

Small molecules are ubiquitous in nature and their detection is relevant in various domains. However, due to their size, sensitive and selective probes are difficult to select and the detection methods are generally indirect. In this study, we introd...

  • Communication
  • Open Access
41 Citations
5,457 Views
8 Pages

8 April 2021

A simple and low-cost procedure for gel-like time-durable biological phantoms is presented in this work. Easily accessible materials are adopted, which are able to provide a flexible and controllable method to rapidly realize different kind of tissue...

  • Article
  • Open Access
31 Citations
4,817 Views
10 Pages

A Self-Powered Portable Flexible Sensor of Monitoring Speed Skating Techniques

  • Zhuo Lu,
  • Yongsheng Zhu,
  • Changjun Jia,
  • Tianming Zhao,
  • Meiyue Bian,
  • Chaofeng Jia,
  • Yiqiao Zhang and
  • Yupeng Mao

7 April 2021

With the development of 5G technology, contemporary technologies such as Internet of Things (IoT) and Big Data analyses have been widely applied to the sport industry. This paper focuses on the design of a portable, self-powered, flexible sensor, whi...

  • Article
  • Open Access
25 Citations
8,750 Views
12 Pages

7 April 2021

This study aimed to develop simple electrochemical electrodes for the fast detection of chloride, sodium and potassium ions in human serum. A flat thin-film gold electrode was used as the detection electrode for chloride ions; a single-piece type mem...

  • Review
  • Open Access
50 Citations
9,909 Views
21 Pages

7 April 2021

This review summarizes the state of the art of paper-based biosensors (PBBs) for coronavirus disease 2019 (COVID-19) detection. Three categories of PBB are currently being been used for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) dia...

  • Review
  • Open Access
52 Citations
7,952 Views
23 Pages

4 April 2021

Over the last 30 years, optical biosensors based on nanostructured materials have obtained increasing interest since they allow the screening of a wide variety of biomolecules with high specificity, low limits of detection, and great sensitivity. Amo...

  • Article
  • Open Access
1 Citations
2,923 Views
14 Pages

3 April 2021

To ascertain how scalloped hammerhead sharks make nightly migrations to their feeding grounds as many as 20 km from their daytime abode, a seamount, a sensor was developed that measured irradiance intensity within the spectral range and sensitivity o...

  • Communication
  • Open Access
2 Citations
4,593 Views
10 Pages

3 April 2021

In this paper, a rapid test system with high sensitivity, linearity, and stability is presented for fecal occult blood (FOB) detection. The coloration results of the immune response are used as the basis for the determination of the detection target...

  • Article
  • Open Access
17 Citations
4,643 Views
17 Pages

Contactless Temperature Sensing at the Microscale Based on Titanium Dioxide Raman Thermometry

  • Veronica Zani,
  • Danilo Pedron,
  • Roberto Pilot and
  • Raffaella Signorini

2 April 2021

The determination of local temperature at the nanoscale is a key point to govern physical, chemical and biological processes, strongly influenced by temperature. Since a wide range of applications, from nanomedicine to nano- or micro-electronics, req...

  • Review
  • Open Access
71 Citations
10,932 Views
50 Pages

Recent Advances of Field-Effect Transistor Technology for Infectious Diseases

  • Abbas Panahi,
  • Deniz Sadighbayan,
  • Saghi Forouhi and
  • Ebrahim Ghafar-Zadeh

2 April 2021

Field-effect transistor (FET) biosensors have been intensively researched toward label-free biomolecule sensing for different disease screening applications. High sensitivity, incredible miniaturization capability, promising extremely low minimum lim...

  • Article
  • Open Access
80 Citations
5,797 Views
13 Pages

Highly Sensitive Twin Resonance Coupling Refractive Index Sensor Based on Gold- and MgF2-Coated Nano Metal Films

  • Kawsar Ahmed,
  • Mohammed A. AlZain,
  • Hasan Abdullah,
  • Yanhua Luo,
  • Dhasarathan Vigneswaran,
  • Osama S. Faragallah,
  • Mahmoud M. A. Eid and
  • Ahmed Nabih Zaki Rashed

2 April 2021

A plasmonic material-coated circular-shaped photonic crystal fiber (C-PCF) sensor based on surface plasmon resonance (SPR) is proposed to explore the optical guiding performance of the refractive index (RI) sensing at 1.7–3.7 μm. A twin resonance cou...

  • Article
  • Open Access
3,573 Views
17 Pages

Diameter Estimation of Fallopian Tubes Using Visual Sensing

  • Amir M. Hajiyavand,
  • Matthew J. Graham and
  • Karl D. Dearn

1 April 2021

Calculating an accurate diameter of arbitrary vessel-like shapes from 2D images is of great use in various applications within medical and biomedical fields. Understanding the changes in morphological dimensioning of the biological vessels provides a...

  • Article
  • Open Access
36 Citations
6,405 Views
17 Pages

1 April 2021

The electrocardiogram (ECG) electrode, as a sensor, is an important part of the wearable ECG monitoring device. Natural leather is rarely used as the electrode substrate. In this paper, wearable flexible silver electrodes based on cowhide were prepar...

  • Review
  • Open Access
51 Citations
17,514 Views
22 Pages

30 March 2021

Tremors are the most prevalent movement disorder that interferes with the patient’s daily living, and physical activities, ultimately leading to a reduced quality of life. Due to the pathophysiology of tremor, developing effective pharmacotherapies,...

  • Article
  • Open Access
22 Citations
5,307 Views
17 Pages

Electrochemical Trimethylamine N-Oxide Biosensor with Enzyme-Based Oxygen-Scavenging Membrane for Long-Term Operation under Ambient Air

  • Armel F. T. Waffo,
  • Biljana Mitrova,
  • Kim Tiedemann,
  • Chantal Iobbi-Nivol,
  • Silke Leimkühler and
  • Ulla Wollenberger

27 March 2021

An amperometric trimethylamine N-oxide (TMAO) biosensor is reported, where TMAO reductase (TorA) and glucose oxidase (GOD) and catalase (Cat) were immobilized on the electrode surface, enabling measurements of mediated enzymatic TMAO reduction at low...

  • Review
  • Open Access
73 Citations
8,651 Views
13 Pages

Applications of Microwave Energy in Medicine

  • Alexandra Gartshore,
  • Matt Kidd and
  • Lovleen Tina Joshi

26 March 2021

Microwaves are a highly utilized electromagnetic wave, used across a range of industries including food processing, communications, in the development of novel medical treatments and biosensor diagnostics. Microwaves have known thermal interactions a...

  • Review
  • Open Access
70 Citations
9,210 Views
19 Pages

Multi-Functionalized Nanomaterials and Nanoparticles for Diagnosis and Treatment of Retinoblastoma

  • Rabia Arshad,
  • Mahmood Barani,
  • Abbas Rahdar,
  • Saman Sargazi,
  • Magali Cucchiarini,
  • Sadanand Pandey and
  • Misook Kang

26 March 2021

Retinoblastoma is a rare type of cancer, and its treatment, as well as diagnosis, is challenging, owing to mutations in the tumor-suppressor genes and lack of targeted, efficient, cost-effective therapy, exhibiting a significant need for novel approa...

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Biosensors - ISSN 2079-6374