Plasmonic Biosensors for Single-Molecule Biomedical Analysis
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Department of Nursing and Physiotherapy, Universidad de León, Campus de Vegazana, s/n, 24071 León, Spain
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Institute of Food Science and Technology (ICTAL), La Serna 58, 24007 León, Spain
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Nanobiosensors and Bioanalytical Applications Group, Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC, BIST, and CIBER-BBN, Campus UAB, 08193 Barcelona, Spain
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Author to whom correspondence should be addressed.
Biosensors 2021, 11(4), 123; https://doi.org/10.3390/bios11040123
Received: 27 February 2021
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Revised: 18 March 2021
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Accepted: 13 April 2021
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Published: 15 April 2021
(This article belongs to the Special Issue Emerging Nanoplasmonic Technologies in Biosensors)
The rapid spread of epidemic diseases (i.e., coronavirus disease 2019 (COVID-19)) has contributed to focus global attention on the diagnosis of medical conditions by ultrasensitive detection methods. To overcome this challenge, increasing efforts have been driven towards the development of single-molecule analytical platforms. In this context, recent progress in plasmonic biosensing has enabled the design of novel detection strategies capable of targeting individual molecules while evaluating their binding affinity and biological interactions. This review compiles the latest advances in plasmonic technologies for monitoring clinically relevant biomarkers at the single-molecule level. Functional applications are discussed according to plasmonic sensing modes based on either nanoapertures or nanoparticle approaches. A special focus was devoted to new analytical developments involving a wide variety of analytes (e.g., proteins, living cells, nucleic acids and viruses). The utility of plasmonic-based single-molecule analysis for personalized medicine, considering technological limitations and future prospects, is also overviewed.
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Keywords:
single-molecule analysis; biosensors; plasmonics; nanoparticle; nanostructure; nucleic acids; virus; living-cells
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MDPI and ACS Style
Mauriz, E.; Lechuga, L.M. Plasmonic Biosensors for Single-Molecule Biomedical Analysis. Biosensors 2021, 11, 123. https://doi.org/10.3390/bios11040123
AMA Style
Mauriz E, Lechuga LM. Plasmonic Biosensors for Single-Molecule Biomedical Analysis. Biosensors. 2021; 11(4):123. https://doi.org/10.3390/bios11040123
Chicago/Turabian StyleMauriz, Elba, and Laura M. Lechuga. 2021. "Plasmonic Biosensors for Single-Molecule Biomedical Analysis" Biosensors 11, no. 4: 123. https://doi.org/10.3390/bios11040123
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