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Multifunctional NaLnF4@MOF-Ln Nanocomposites with Dual-Mode Luminescence for Drug Delivery and Cell Imaging

1
Key Laboratory of Functional Inorganic Material Chemistry, Ministry of Education, School of Chemistry and Materials Science, Heilongjiang University, Harbin 150080, China
2
Department of Physics and Engineering Physics, The University of Tulsa, Tulsa, OK 74104, USA
*
Authors to whom correspondence should be addressed.
Nanomaterials 2019, 9(9), 1274; https://doi.org/10.3390/nano9091274
Received: 10 August 2019 / Revised: 31 August 2019 / Accepted: 3 September 2019 / Published: 6 September 2019
Multifunctional nanomaterials for bioprobe and drug carrier have drawn great attention for their applications in the early monitoring the progression and treatment of cancers. In this work, we have developed new multifunctional water-soluble NaLnF4@MOF-Ln nanocomposites with dual-mode luminescence, which is based on stokes luminescent mesoporous lanthanide metal–organic frameworks (MOFs-Y:Eu3+) and anti-stokes luminescent NaYF4:Tm3+/Yb3+ nanoparticles. The fluorescence mechanism and dynamics are investigated and the applications of these nanocomposites as bioprobes and drug carriers in the cancer imaging and treatment are explored. Our results demonstrate that these nanocomposites with the excellent two-color emission show great potential in drug delivery, cancer cell imaging, and treatment, which are attributed to the unique spatial structure and good biocompatibility characteristics of NaLnF4@MOF-Ln nanocomposites. View Full-Text
Keywords: metal–organic framework; stokes/anti-stokes emission; dual-mode luminescence; cell imaging; drug delivery metal–organic framework; stokes/anti-stokes emission; dual-mode luminescence; cell imaging; drug delivery
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MDPI and ACS Style

Wang, D.; Zhao, C.; Gao, G.; Xu, L.; Wang, G.; Zhu, P. Multifunctional NaLnF4@MOF-Ln Nanocomposites with Dual-Mode Luminescence for Drug Delivery and Cell Imaging. Nanomaterials 2019, 9, 1274.

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