Correction: Brandão et al. Genotoxicity and Gene Expression in the Rat Lung Tissue following Instillation and Inhalation of Different Variants of Amorphous Silica Nanomaterials (aSiO2 NM). Nanomaterials 2021, 11, 1502
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1
EPIUnit—Instituto de Saúde Pública, Universidade do Porto, Rua das Taipas, 4050-600 Porto, Portugal
2
Laboratory for Integrative and Translational Research in Population Health (ITR), 4050-600 Porto, Portugal
3
Environmental Health Department, National Institute of Health Dr. Ricardo Jorge, Rua Alexandre Herculano 321, 4000-053 Porto, Portugal
4
ICBAS—Institute of Biomedical Sciences Abel Salazar, U. Porto—University of Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal
In the original publication [1], there was a mistake in Table 5 as published. During the proofreading stage, Table 5 was accidentally duplicated with Table 6. The corrected Table 5 appears below.
Table 5.
Main affected pathways in Gene Ontology (GO) in rats exposed by instillation to SiO2_15_Unmod and SiO2_15_Amino.
The authors state that the scientific conclusions are unaffected. This correction was approved by the Academic Editor. The original publication has also been updated.
Reference
Brandão, F.; Costa, C.; Bessa, M.J.; Dumortier, E.; Debacq-Chainiaux, F.; Hubaux, R.; Salmon, M.; Laloy, J.; Stan, M.S.; Hermenean, A.; et al. Genotoxicity and Gene Expression in the Rat Lung Tissue following Instillation and Inhalation of Different Variants of Amorphous Silica Nanomaterials (aSiO2 NM). Nanomaterials2021, 11, 1502. [Google Scholar] [CrossRef] [Scilit] [PubMed]
Table 5.
Main affected pathways in Gene Ontology (GO) in rats exposed by instillation to SiO2_15_Unmod and SiO2_15_Amino.
Table 5.
Main affected pathways in Gene Ontology (GO) in rats exposed by instillation to SiO2_15_Unmod and SiO2_15_Amino.
NM
Exposure Condition
Rank
Id
Size
p Value
Description
SiO2_15_Unmod
Exposure Group
1
GO:0007127
83 (112)
6.00 × 10−7
meiosis I
2
GO:0048247
42 (46)
3.50 × 10−6
lymphocyte chemotaxis
3
GO:0071459
15 (21)
5.20 × 10−6
protein localization to chromosome, centromeric
4
GO:0060340
10 (11)
8.20 × 10−6
positive regulation of type I interferon-mediated
5
GO:0070098
63 (66)
1.30 × 10−5
chemokine-mediated signaling pathway
6
GO:0072676
73 (78)
2.00 × 10−5
lymphocyte migration
7
GO:0045132
67 (93)
3.20 × 10−5
meiotic chromosome segregation
8
GO:0034501
13 (18)
4.20 × 10−5
protein localization to kinetochore
9
GO:0034502
64 (76)
1.80 × 10−4
protein localization to chromosome
10
GO:0070192
53 (72)
1.90 × 10−4
chromosome organization involved in meiotic cell cycle
Recovery Group
1
GO:0048680
9 (11)
2.20 × 10−5
positive regulation of axon regeneration
2
GO:0070572
10 (12)
8.80 × 10−5
positive regulation of neuron projection
3
GO:2001223
10 (11)
1.60 × 10−4
negative regulation of neuron migration
4
GO:2000849
11 (11)
1.60 × 10−4
regulation of glucocorticoid secretion
5
GO:0071300
65 (76)
3.30 × 10−4
cellular response to retinoic acid
6
GO:0003348
6 (6)
3.60 × 10−4
cardiac endothelial cell differentiation
7
GO:0060956
6 (6)
3.60 × 10−4
endocardial cell differentiation
8
GO:0006297
5 (5)
3.70 × 10−4
nucleotide-excision repair, DNA gap filling
9
GO:0035933
12 (12)
5.10 × 10−4
glucocorticoid secretion
10
GO:2000852
5 (5)
5.50 × 10−4
regulation of corticosterone secretion
SiO2_15_Amino
Exposure Group
1
GO:0000910
96 (110)
1.50 × 10−7
cytokinesis
2
GO:0000281
42 (47)
4.00 × 10−7
mitotic cytokinesis
3
GO:0033260
23 (30)
5.40 × 10−6
nuclear DNA replication
4
GO:0071459
15 (21)
7.60 × 10−6
protein localization to chromosome, centromeric
5
GO:0051383
12 (14)
1.80 × 10−5
kinetochore organization
6
GO:0051414
7 (7)
2.00 × 10−5
response to cortisol
7
GO:0040020
31 (35)
2.30 × 10−5
regulation of meiotic nuclear division
8
GO:0061640
49 (56)
2.50 × 10−5
cytoskeleton-dependent cytokinesis
9
GO:0051445
45 (51)
2.50 × 10−5
regulation of meiotic cell cycle
10
GO:1902969
9 (10)
3.90 × 10−5
mitotic DNA replication
Recovery Group
1
GO:0035082
44 (60)
1.90 × 10−14
axoneme assembly
2
GO:0003341
44 (64)
7.10 × 10−13
cilium movement
3
GO:0001578
66 (89)
4.80 × 10−8
microtubule bundle formation
4
GO:0002385
25 (39)
2.60 × 10−5
mucosal immune response
5
GO:0060294
15 (17)
3.50 × 10−5
cilium movement involved in cell motility
6
GO:0030199
38 (44)
5.10 × 10−5
collagen fibril organization
7
GO:0001539
19 (22)
5.20 × 10−5
cilium or flagellum-dependent cell motility
8
GO:0060285
19 (22)
5.20 × 10−5
cilium-dependent cell motility
9
GO:0002251
26 (40)
5.20 × 10−5
organ or tissue specific immune response
10
GO:0048755
13 (13)
6.50 × 10−5
branching morphogenesis of a nerve
Rats were exposed by instillation to 0.36 mg of SiO2_15_Unmod or SiO2_15_Amino and euthanized to isolate total RNA from the lungs both at 3 days (Exposure group; E) and 21 days (Recovery group; R) after initial instillation.
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