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Journal of Functional Biomaterials, Volume 15, Issue 4

2024 April - 32 articles

Cover Story: This work uses finite element analysis (FEA) to combine biomimetic Voronoi lattice structures that simulate the cancellous bone of the human jaw to advance dental implant designs. It utilizes nTOP 4.17.3 and Creo Parametric 8.0 to accurately mimic the trabecular bone's complicated porosity and biomechanical properties. The research presented improves the biomechanical performance of dental implants during dynamic mastication by varying pore diameters from 1.0 to 2.5 mm. These findings indicate the ideal pore size, which is consistent with natural bone mechanics, thereby significantly improving osseointegration and stability. Indeed, this is an important step in the development of long-lasting, patient-specific implants, thus laying the foundations for the next generation of dental treatments. View this paper
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Articles (32)

  • Article
  • Open Access
10 Citations
3,134 Views
11 Pages

Angiogenesis is vital for bone fracture healing and plays a significant role in the fate of orthopedic implants. The growth and maintenance of new blood vessels at the fracture site of patients is essential, which promotes the clinical outcome of pla...

  • Article
  • Open Access
9 Citations
2,467 Views
17 Pages

As an essential nutrient, lutein (LUT) has the ability to aid in the prevention of eye diseases, cardiovascular diseases, and cancer. However, the application of LUT is largely restricted by its poor solubility and susceptibility to oxidative degrada...

  • Article
  • Open Access
2 Citations
2,208 Views
34 Pages

Performance of Austenitic High-Nitrogen Steels under Gross Slip Fretting Corrosion in Bovine Serum

  • Alfons Fischer,
  • Philipe Telouk,
  • Christian Beckmann,
  • Saskia Heermant,
  • Adrian Wittrock,
  • Jörg Debus and
  • Markus A. Wimmer

Modular artificial hip joints are a clinical standard today. However, the release of wear products from the head–taper interface, which includes wear particles in the nm size range, as well as metal ions, have raised concerns. Depending on the...

  • Article
  • Open Access
9 Citations
4,045 Views
16 Pages

In recent years, the use of zinc (Zn) alloys as degradable metal materials has attracted considerable attention in the field of biomedical bone implant materials. This study investigates the fabrication of porous scaffolds using a Zn-1Mg-0.1Sr alloy...

  • Article
  • Open Access
1 Citations
2,344 Views
16 Pages

Biological and Mechanical Performance of Dual-Setting Brushite–Silica Gel Cements

  • Valentin C. Steinacker,
  • Tobias Renner,
  • Ib Holzmeister,
  • Sebastian Gubik,
  • Urs Müller-Richter,
  • Niko Breitenbücher,
  • Andreas Fuchs,
  • Anton Straub,
  • Mario Scheurer and
  • Uwe Gbureck
  • + 1 author

Bone defects resulting from trauma, diseases, or surgical procedures pose significant challenges in the field of oral and maxillofacial surgery. The development of effective bone substitute materials that promote bone healing and regeneration is cruc...

  • Editorial
  • Open Access
1 Citations
2,622 Views
4 Pages

This Special Issue, “Functional Biomaterials and Digital Technologies in Dentistry: From Bench to Bedside”, highlights the integration of advanced materials science and digital technologies in dental and maxillofacial applications [...]

  • Article
  • Open Access
5 Citations
3,313 Views
12 Pages

In orthopaedics, erythropoietin (EPO) is applied in the preoperative management of anaemic patients, but also as a stimulating factor to assist bone regeneration due to its angiogenic and osteoinductive potential. Since orthopaedists mainly rely on t...

  • Article
  • Open Access
10 Citations
2,948 Views
13 Pages

Strontium-Doped Bioglass-Laden Gelatin Methacryloyl Hydrogels for Vital Pulp Therapy

  • Sepideh Aminmansour,
  • Ana Beatriz Gomes de Carvalho,
  • Lais Medeiros Cardoso,
  • Caroline Anselmi,
  • Maedeh Rahimnejad,
  • Renan Dal-Fabbro,
  • Erika Benavides,
  • Tiago Moreira Bastos Campos,
  • Alexandre Luiz Souto Borges and
  • Marco C. Bottino

This study aimed to develop gelatin methacryloyl (GelMA)-injectable hydrogels incorporated with 58S bioactive glass/BG-doped with strontium for vital pulp therapy applications. GelMA hydrogels containing 0% (control), 5%, 10%, and 20% BG (w/v) were p...

  • Article
  • Open Access
4 Citations
2,991 Views
12 Pages

Binary Mixtures of Meloxicam and L-Tartaric Acid for Oral Bioavailability Modulation of Pharmaceutical Dosage Forms

  • Cristina Macasoi,
  • Viorica Meltzer,
  • Ioana Stanculescu,
  • Cosmin Romanitan and
  • Elena Pincu

Binary mixtures of active pharmaceutical ingredients (API) are researched to improve the oral bioavailability of pharmaceutical dosage forms. The purpose of this study was to obtain mixtures of meloxicam and L-tartaric acid because tartaric acid impr...

  • Review
  • Open Access
21 Citations
8,034 Views
29 Pages

Zinc Oxide-Based Nanomaterials for Microbiostatic Activities: A Review

  • Alemtsehay Tesfay Reda,
  • Jae Yeon Park and
  • Yong Tae Park

The world is fighting infectious diseases. Therefore, effective antimicrobials are required to prevent the spread of microbes and protect human health. Zinc oxide (ZnO) nano-materials are known for their antimicrobial activities. Because of their dis...

  • Article
  • Open Access
3 Citations
2,286 Views
18 Pages

A Novel Method for Fabricating the Undulating Structures at Dermal—Epidermal Junction by Composite Molding Process

  • Hao Qiao,
  • Chuang Gao,
  • Chunxiang Lu,
  • Huazhen Liu,
  • Yi Zhang,
  • Aoxiang Jin,
  • Qiqi Dai,
  • Shihmo Yang,
  • Bing Zhang and
  • Yuanyuan Liu

The dermal–epidermal junction (DEJ), located between the dermal–epidermal layers in human skin tissue, plays a significant role in its function. However, the limitations of biomaterial properties and microstructure fabrication methods mea...

  • Article
  • Open Access
8 Citations
3,438 Views
14 Pages

Biomechanical Effects of Ti-Base Abutment Height on the Dental Implant System: A Finite Element Analysis

  • Miguel Beltrán-Guijarro,
  • Esteban Pérez-Pevida,
  • David Chávarri-Prado,
  • Alejandro Estrada-Martínez,
  • Markel Diéguez-Pereira,
  • Fernando Sánchez-Lasheras and
  • Aritza Brizuela-Velasco

This study aims to analyse, using a finite element analysis, the effects of Ti-base abutment height on the distribution and magnitude of transferred load and the resulting bone microstrain in the bone-implant system. A three-dimensional bone model of...

  • Article
  • Open Access
14 Citations
3,137 Views
13 Pages

This study explored the chemical and antibacterial properties of a dental resin loaded with gold nanoshells (AuNPs) in conjunction with photothermal therapy (PTT) as a novel method against Streptococcus mutans (S. mutans) to prevent secondary caries....

  • Article
  • Open Access
6 Citations
5,155 Views
13 Pages

This study presents the first 10-year follow-up investigation of the implant survival and peri-implant outcomes of one-piece mini dental implants (MDIs) retaining mandibular implant overdentures (IODs), including marginal bone level alterations (&Del...

  • Article
  • Open Access
2 Citations
2,512 Views
14 Pages

Plasma Gel Matrix as a Promising Carrier of Epigallocatechin Gallate for Regenerative Medicine

  • Takashi Ushiki,
  • Tomoharu Mochizuki,
  • Mami Osawa,
  • Katsuya Suzuki,
  • Tetsuhiro Tsujino,
  • Taisuke Watanabe,
  • Carlos Fernando Mourão and
  • Tomoyuki Kawase

Plasma gel (PG) is a protein matrix prepared from platelet-poor plasma and can be utilized as a drug carrier for controlled release. We previously demonstrated its applicability as a carrier of polyphosphate. Epigallocatechin-3-gallate (EGCG) is the...

  • Article
  • Open Access
4 Citations
2,277 Views
15 Pages

Functionalization of PCL-Based Fiber Scaffolds with Different Sources of Calcium and Phosphate and Odontogenic Potential on Human Dental Pulp Cells

  • Caroline Anselmi,
  • Igor Paulino Mendes Soares,
  • Rafaella Lara Maia Mota,
  • Maria Luísa Leite,
  • Rafael Antonio de Oliveira Ribeiro,
  • Lídia de Oliveira Fernandes,
  • Marco C. Bottino,
  • Carlos Alberto de Souza Costa and
  • Josimeri Hebling

This study investigated the incorporation of sources of calcium, phosphate, or both into electrospun scaffolds and evaluated their bioactivity on human dental pulp cells (HDPCs). Additionally, scaffolds incorporated with calcium hydroxide (CH) were c...

  • Article
  • Open Access
5 Citations
5,307 Views
15 Pages

Dental Implant Abutment Screw Loss: Presentation of 10 Cases

  • Maryam Soleimani,
  • Jarosław Żmudzki,
  • Wojciech Pakieła,
  • Anna Jaśkowska and
  • Kornel Krasny

Re-tightening the loosened dental implant abutment screw is an accepted procedure, however the evidence that such screw will hold sufficiently is weak. The purpose of this study was material analysis of lost dental implant abutment screws made of the...

  • Article
  • Open Access
15 Citations
4,361 Views
24 Pages

Green Synthesis of Gold Nanoparticles Using Liquiritin and Other Phenolics from Glycyrrhiza glabra and Their Anti-Inflammatory Activity

  • Ali O. E. Eltahir,
  • Kim L. Lategan,
  • Oladipupo M. David,
  • Edmund J. Pool,
  • Robert C. Luckay and
  • Ahmed A. Hussein

Phenolic compounds are the main phytochemical constituents of many higher plants. They play an important role in synthesizing metal nanoparticles using green technology due to their ability to reduce metal salts and stabilize them through physical in...

  • Article
  • Open Access
15 Citations
5,328 Views
22 Pages

The human mandible’s cancellous bone, which is characterized by its unique porosity and directional sensitivity to external forces, is crucial for sustaining biting stress. Traditional computer- aided design (CAD) models fail to fully represent...

  • Review
  • Open Access
19 Citations
3,491 Views
33 Pages

Advancements in Hybrid Cellulose-Based Films: Innovations and Applications in 2D Nano-Delivery Systems

  • Ghazaleh Ramezani,
  • Ion Stiharu,
  • Theo G. M. van de Ven and
  • Vahe Nerguizian

This review paper delves into the realm of hybrid cellulose-based materials and their applications in 2D nano-delivery systems. Cellulose, recognized for its biocompatibility, versatility, and renewability, serves as the core matrix for these nanomat...

  • Article
  • Open Access
4 Citations
2,420 Views
11 Pages

Nitric Oxide Photorelease from Silicone Films Doped with N-Nitroso BODIPY

  • Natalia A. Virts,
  • Tatyana Yu. Karogodina,
  • Mikhail A. Panfilov,
  • Alexey Yu. Vorob’ev and
  • Alexander E. Moskalensky

Nitric oxide (NO) is a unique biochemical mediator involved in the regulation of vital processes. Light-controllable NO releasers show promise in the development of smart therapies. Here, we present a novel biocompatible material based on polydimethy...

  • Review
  • Open Access
13 Citations
4,377 Views
11 Pages

Zirconia ceramic implants are commercially available from a rapidly growing number of manufacturers. Macroscopic and microscopic surface design and characteristics are considered to be key determining factors in the success of the osseointegration pr...

  • Article
  • Open Access
9 Citations
4,149 Views
14 Pages

Synthesis of bioinks for bioprinting of respiratory tissue requires considerations related to immunogenicity, mechanical properties, printability, and cellular compatibility. Biomaterials can be tailored to provide the appropriate combination of thes...

  • Article
  • Open Access
4 Citations
3,126 Views
17 Pages

A New Hyaluronic Emulgel of Hesperetin for Topical Application—An In Vitro Evaluation

  • Raquel Taléns-Visconti,
  • Yousra Belarbi,
  • Octavio Díez-Sales,
  • Jesus Vicente de Julián-Ortiz,
  • Ofelia Vila-Busó and
  • Amparo Nácher

The present study aimed to formulate and characterize a hesperetin formulation to achieve adequate deposition and retention of hesperetin in the epidermis as a target for some cosmetic/dermatological actions. To derive the final emulgel, various form...

  • Article
  • Open Access
4 Citations
3,193 Views
17 Pages

Influence of Magnesium Degradation on Schwannoma Cell Responses to Nerve Injury Using an In Vitro Injury Model

  • Krathika Bhat,
  • Lisa Hanke,
  • Heike Helmholz,
  • Eckhard Quandt,
  • Sarah Pixley and
  • Regine Willumeit-Römer

Nerve guidance conduits for peripheral nerve injuries can be improved using bioactive materials such as magnesium (Mg) and its alloys, which could provide both structural and trophic support. Therefore, we investigated whether exposure to Mg and Mg-1...

  • Article
  • Open Access
5 Citations
3,251 Views
18 Pages

A Novel Viscoelastic Deformation Mechanism Uncovered during Vickers Hardness Study of Bone

  • Ahmed Ibrahim,
  • Zhenting Jiang,
  • Khosro Shirvani,
  • Alireza Dalili and
  • Z. Abdel Hamid

This study investigates the viscoelastic deformation mechanisms of bone as a response to Vickers hardness indentation. We utilized advanced high-resolution scanning electron microscopy (SEM) to investigate a distinct deformation pattern that originat...

  • Article
  • Open Access
5 Citations
2,961 Views
22 Pages

A Finite Element Method Study on a Simulation of the Thermal Behaviour of Four Methods for the Restoration of Class II Cavities

  • Adela Nicoleta Staicu,
  • Mihaela Jana Țuculină,
  • Cristian Niky Cumpătă,
  • Ana Maria Rîcă,
  • Maria Cristina Beznă,
  • Dragoș Laurențiu Popa,
  • Alexandru Dan Popescu and
  • Oana Andreea Diaconu

The possibility of dental pulp damage during dental procedures is well known. According to studies, during finishing and polishing without cooling, temperatures of up to 140 °C or more can be generated. There are many studies that have analysed t...

  • Article
  • Open Access
6 Citations
3,699 Views
13 Pages

Assessment of the Cyclic Fatigue Performance of the Novel Protaper Ultimate File System Used in Different Kinematics: An In Vitro Study

  • Cezar Tiberiu Diaconu,
  • Anca Elena Diaconu,
  • Mihaela Jana Tuculina,
  • Laurența Lelia Mihai,
  • Mircea Gheorghiță,
  • Lelia Mihaela Gheorghiță,
  • Petre Mărășescu,
  • Alexandru Gliga and
  • Oana Andreea Diaconu

This in vitro study aims to assess the cyclic fatigue resistance of the Protaper Ultimate (PTU) files compared to the Protaper Gold (PTG) and the M3 UDG (M3) files using various motion kinematics in simulated canals. As far as the authors are aware,...

  • Review
  • Open Access
14 Citations
7,305 Views
35 Pages

Acquired cranial defects are a prevalent condition in neurosurgery and call for cranioplasty, where the missing or defective cranium is replaced by an implant. Nevertheless, the biomaterials in current clinical applications are hardly exempt from lon...

  • Review
  • Open Access
26 Citations
7,218 Views
17 Pages

Animal Models for Investigating Osseointegration: An Overview of Implant Research over the Last Three Decades

  • Antonio Scarano,
  • Ahmad G. A. Khater,
  • Sergio Alexandre Gehrke,
  • Francesco Inchingolo and
  • Sergio Rexhep Tari

Dental implants and bone augmentation are among dentistry’s most prevalent surgical treatments; hence, many dental implant surfaces and bone grafts have been researched to improve bone response. Such new materials were radiologically, histologi...

  • Article
  • Open Access
6 Citations
3,073 Views
12 Pages

Applications of Cu2+-Loaded Silica Nanoparticles to Photothermal Therapy and Tumor-Specific Fluorescence Imaging

  • Ji-Ho Park,
  • Yejin Sung,
  • SeongHoon Jo,
  • Seung Ho Lee,
  • Ju Hee Ryu,
  • In-Cheol Sun and
  • Cheol-Hee Ahn

Copper-based nanomaterials have been employed as therapeutic agents for cancer therapy and diagnosis. Nevertheless, persistent challenges, such as cellular toxicity, non-uniform sizes, and low photothermal efficiency, often constrain their applicatio...

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J. Funct. Biomater. - ISSN 2079-4983