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Open AccessReview

Diagnostic and Therapeutic Management of Upper Extremity Deep Vein Thrombosis

Department of Internal Medicine, Tergooi Hospitals, 1213 XZ Hilversum, The Netherlands
Department of Vascular Medicine, Amsterdam Cardiovascular Science, Amsterdam UMC, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
Department of Medicine and Ageing Sciences, Gabriele D′Annunzio University, Via dei Vestini 31, 66100 Chieti, Italy
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(7), 2069;
Received: 19 May 2020 / Revised: 25 June 2020 / Accepted: 29 June 2020 / Published: 1 July 2020
(This article belongs to the Special Issue Venous Thromboembolism — Diagnosis, Prevention and Treatment)
Upper extremity deep vein thrombosis (UEDVT) accounts for 5% of all deep vein thromboses (DVTs). UEDVT may be complicated by post thrombotic syndrome and pulmonary embolism, and early recognition and prompt start of anticoagulant treatment are key. Primary UEDVT, also known as Paget-von Schrötter syndrome, is associated with repeated or sudden physical activity of the upper arm and venous outflow obstruction due to anatomical variations. Secondary UEDVT is often associated with malignancy or use of intravenous devices, such as central venous catheters or pacemaker leads. Although the diagnosis and treatment of UEDVT have many similarities with DVT of the lower extremities, knowledge of specific aspects regarding UEDVT is important to guide optimal management. In this review, we will discuss the epidemiology, diagnosis, and treatment of UEDVT based on the current literature. View Full-Text
Keywords: upper extremity deep vein thrombosis; epidemiology; diagnosis; treatment upper extremity deep vein thrombosis; epidemiology; diagnosis; treatment
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Bosch, F.T.M.; Nisio, M.D.; Büller, H.R.; van Es, N. Diagnostic and Therapeutic Management of Upper Extremity Deep Vein Thrombosis. J. Clin. Med. 2020, 9, 2069.

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