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Open AccessArticle

Expression of EEF1A1 Is Associated with Prognosis of Patients with Colon Adenocarcinoma

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Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea
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Department of Pathology, Incheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea
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Department of General Surgery, Incheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea
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Deargen Inc., Daejeon 34051, Korea
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Department of Microbiology, College of Natural Sciences, Dankook University, Cheonan 31116, Korea
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Department of Molecular Medicine and Tissue Injury Defense Research Center, College of Medicine, Ewha Womans University, Seoul 03760, Korea
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Division of Oncology, Department of Internal Medicine, Eunpyeong St. Mary’s Hospital, The Catholic University of Korea, Seoul 03312, Korea
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Cancer Research Institute, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea
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Division of Oncology, Department of Internal Medicine, Incheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea
*
Authors to whom correspondence should be addressed.
Eun kyo Joung and Jiyoung Kim contributed equally to this study.
J. Clin. Med. 2019, 8(11), 1903; https://doi.org/10.3390/jcm8111903
Received: 21 September 2019 / Revised: 31 October 2019 / Accepted: 4 November 2019 / Published: 7 November 2019
(This article belongs to the Section Oncology)
Background: The prognostic role of the translational factor, elongation factor-1 alpha 1 (EEF1A1), in colon cancer is unclear. Objectives: The present study aimed to investigate the expression of EEF1A in tissues obtained from patients with stage II and III colon cancer and analyze its association with patient prognosis. Methods: A total of 281 patients with colon cancer who underwent curative resection were analyzed according to EEF1A1 expression. Results: The five-year overall survival in the high-EEF1A1 group was 87.7%, whereas it was 65.6% in the low-EEF1A1 expression group (hazard ratio (HR) 2.47, 95% confidence interval (CI) 1.38–4.44, p = 0.002). The five-year disease-free survival of patients with high EEF1A1 expression was 82.5%, which was longer than the rate of 55.4% observed for patients with low EEF1A1 expression (HR 2.94, 95% CI 1.72–5.04, p < 0.001). Univariate Cox regression analysis indicated that age, preoperative carcinoembryonic antigen level, adjuvant treatment, total number of metastatic lymph nodes, and EEF1A1 expression level were significant prognostic factors for death. In multivariate analysis, expression of EEF1A1 was an independent prognostic factor associated with death (HR 3.01, 95% CI 1.636–5.543, p < 0.001). EEF1A1 expression was also an independent prognostic factor for disease-free survival in multivariate analysis (HR 2.54, 95% CI 1.459–4.434, p < 0.001). Conclusions: Our study demonstrated that high expression of EEF1A1 has a favorable prognostic effect on patients with colon adenocarcinoma. View Full-Text
Keywords: cancer biomarker; colon adenocarcinoma; elongation factor-1 alpha 1; prognosis; translation factor cancer biomarker; colon adenocarcinoma; elongation factor-1 alpha 1; prognosis; translation factor
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Joung, E.; Kim, J.; Yoon, N.; Maeng, L.-S.; Kim, J.H.; Park, S.; Kang, K.; Kim, J.S.; Ahn, Y.-H.; Ko, Y.H.; Byun, J.H.; Hong, J.H. Expression of EEF1A1 Is Associated with Prognosis of Patients with Colon Adenocarcinoma. J. Clin. Med. 2019, 8, 1903.

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