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Open AccessReview

Bronchiectasis in the Last Five Years: New Developments

Department of Respiratory Medicine, Western Health, Melbourne 3011, VIC, Australia
Department of Respiratory Medicine, Prince of Wales, Sydney 2031, NSW, Australia
Department of Respiratory Medicine, Middlemore Hospital, Auckland 2025, New Zealand
Melbourne Medical School Western Precinct, The University of Melbourne, Melbourne 3021, VIC, Australia
Author to whom correspondence should be addressed.
Academic Editor: David Barnes
J. Clin. Med. 2016, 5(12), 115;
Received: 28 September 2016 / Revised: 24 November 2016 / Accepted: 25 November 2016 / Published: 8 December 2016
(This article belongs to the Special Issue Chronic Respiratory Diseases)
Bronchiectasis, a chronic lung disease characterised by cough and purulent sputum, recurrent infections, and airway damage, is associated with considerable morbidity and mortality. To date, treatment options have been limited to physiotherapy to clear sputum and antibiotics to treat acute infections. Over the last decade, there has been significant progress in understanding the epidemiology, pathophysiology, and microbiology of this disorder. Over the last five years, methods of assessing severity have been developed, the role of macrolide antibiotic therapy in reducing exacerbations cemented, and inhaled antibiotic therapies show promise in the treatment of chronic Pseudomonas aeruginosa infection. Novel therapies are currently undergoing Phase 1 and 2 trials. This review aims to address the major developments within the field of bronchiectasis over this time. View Full-Text
Keywords: bronchiectasis; severity scores; microbiome; comorbidities; treatment bronchiectasis; severity scores; microbiome; comorbidities; treatment
MDPI and ACS Style

Khoo, J.K.; Venning, V.; Wong, C.; Jayaram, L. Bronchiectasis in the Last Five Years: New Developments. J. Clin. Med. 2016, 5, 115.

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