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Journal of Clinical Medicine, Volume 14, Issue 4

February-2 2025 - 363 articles

Cover Story: Neuroblastoma is a common childhood malignancy, and high-risk presentations, including an amplified MYCN status, continue to result in poor survival. Difluoromethylornithine (DFMO) is a new and well-tolerated treatment for high-risk neuroblastoma. This review article discusses preclinical and clinical data that resulted in the establishment of DFMO as a treatment for neuroblastoma. The review of preclinical data includes a summary of the contribution of polyamine synthetic pathways to high-risk neuroblastoma, the effect that MYCN has on polyamine synthetic pathways, and the proposed mechanism by which DFMO inhibits tumorigenesis. This understanding has led to the discussion of various preclinical combination therapies that may result in a synergistic therapeutic response for high-risk neuroblastoma. View this paper
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Articles (363)

  • Review
  • Open Access
1 Citations
5,160 Views
15 Pages

Smoking Cessation Strategies After Acute Coronary Syndrome

  • Anum Nazir,
  • Smrthi Shetty Ujjar,
  • Moncef Oualid Seddiki,
  • Mala Jheinga and
  • Lampson Fan

19 February 2025

Smoking is one of the strongest modifiable risk factors for coronary artery disease. It is the cause of approximately 10–30% of deaths due to cardiovascular disease around the world. There is a 50% reduction in the risk of myocardial infarction...

  • Article
  • Open Access
1,633 Views
10 Pages

19 February 2025

Background/Objective: The rise in sports participation among children and adolescents has led to an increase in ACL injuries in skeletally immature individuals. This study analyzed nationwide trends in the anterior cruciate ligament (ACL) reconstruct...

  • Review
  • Open Access
2 Citations
8,200 Views
25 Pages

19 February 2025

Background: Musculoskeletal disorders associated with excessive smartphone use represent a significant health issue. Text neck syndrome is one such disorder within that group, increasingly affecting individuals worldwide across various age groups. Th...

  • Systematic Review
  • Open Access
8 Citations
3,229 Views
19 Pages

Changes in Respiratory Viruses’ Activity in Children During the COVID-19 Pandemic: A Systematic Review

  • Marco Maglione,
  • Vincenzo Tipo,
  • Emiliano Barbieri,
  • Roberta Ragucci,
  • Agnese Sara Ciccarelli,
  • Chiara Esposito,
  • Ludovica Carangelo and
  • Antonietta Giannattasio

19 February 2025

Background/Objectives: The impact of the coronavirus disease 2019 (COVID-19) pandemic on health was significant worldwide. The measures adopted to limit the spread of the virus had an indirect effect on the epidemiology of other infectious diseases w...

  • Review
  • Open Access
5 Citations
11,709 Views
22 Pages

Comprehensive Review of Endometrial Cancer: New Molecular and FIGO Classification and Recent Treatment Changes

  • Maria-Bianca Anca-Stanciu,
  • Andrei Manu,
  • Maria Victoria Olinca,
  • Cătălin Coroleucă,
  • Diana-Elena Comandașu,
  • Ciprian Andrei Coroleuca,
  • Calina Maier and
  • Elvira Bratila

19 February 2025

Endometrial cancer (EC) is the most common gynecologic malignancy in developed countries, with rising incidence due to aging populations and obesity-related factors. This review explores the evolving molecular and FIGO classifications of EC, highligh...

  • Article
  • Open Access
1 Citations
1,634 Views
13 Pages

19 February 2025

Background/Objectives: Acute kidney injury (AKI) is a serious and prevalent complication of COVID-19. This study examines the prevalence, risk factors, and outcomes of AKI in hospitalized COVID-19 patients. Methods: We analyzed the data of 1223 adult...

  • Review
  • Open Access
1 Citations
1,274 Views
8 Pages

Simultaneous Medullary and Papillary Thyroid Carcinomas: Personal Experience Report and Literature Review

  • Nadia De Falco,
  • Massimo Agresti,
  • Massimo De Falco,
  • Pasquale Sperlongano,
  • Giancarlo Moccia,
  • Pasquale Luongo,
  • Alessio Cece,
  • Francesco Bove,
  • Francesco Miele and
  • Alfredo Allaria
  • + 9 authors

19 February 2025

While the frequency of papillary thyroid carcinoma (PTC) has increased in recent decades, both due to improvements in diagnostic procedures and a real, effective percentage increase in cases, the frequency of medullary thyroid carcinoma (MTC), howeve...

  • Article
  • Open Access
1 Citations
1,647 Views
13 Pages

Sentinel Lymph Node Detection in Cervical Cancer: Challenges in Resource-Limited Settings with High Prevalence of Large Tumours

  • Szilárd Leó Kiss,
  • Mihai Stanca,
  • Dan Mihai Căpîlna,
  • Tudor Emil Căpîlna,
  • Maria Pop-Suciu,
  • Botond Istvan Kiss,
  • Szilárd Leó Kiss and
  • Mihai Emil Căpîlna

19 February 2025

Background/Objectives: Cervical cancer primarily disseminates through the lymphatic system, with the metastatic involvement of pelvic and para-aortic lymph nodes significantly impacting prognosis and treatment decisions. Sentinel lymph node (SLN) map...

  • Feature Paper
  • Article
  • Open Access
1,024 Views
18 Pages

Clinical and Economic Impact of a First Major Bleeding Event in Non-Anticoagulated Patients in Spain: A 3-Year Retrospective Observational Cohort Study

  • Carlos Escobar,
  • Beatriz Palacios,
  • Miriam Villarreal,
  • Martín Gutiérrez,
  • Margarita Capel,
  • Ignacio Hernández,
  • María García,
  • Laura Lledó and
  • Juan F. Arenillas

19 February 2025

Objective: To analyze clinical characteristics of non-anticoagulated subjects with major bleeding, and to determine the incidence of adverse events, healthcare resource utilization (HCRU) and associated costs following a major bleeding event. Methods...

  • Article
  • Open Access
2,427 Views
18 Pages

19 February 2025

Objective: The aim of this study was to determine mortality and predictive factors for death in patients with rheumatoid arthritis (RA) diagnosed with and without interstitial lung disease (ILD). Methods: We retrospectively performed a long-term foll...

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J. Clin. Med. - ISSN 2077-0383Creative Common CC BY license