Validation of Kidney Donor Profile Index and Estimated Post-Transplant Survival Scores in an Eastern European Transplantation Center—A Seven-Year Retrospective Observational Study

Elec, Florin Ioan; Moisoiu, Tudor; Negrut, Matei Florin; Simon, Robert; Elec, Alina Daciana; Muntean, Adriana Milena; Horciag, Georgeta; Sitaru, Ana Maria; Rachisan, Andreea Liana; Oniscu, Gabriel; Antal, Oana

doi:10.3390/jcm14103540

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Validation of Kidney Donor Profile Index and Estimated Post-Transplant Survival Scores in an Eastern European Transplantation Center—A Seven-Year Retrospective Observational Study

by

Florin Ioan Elec

^1,2

,

Tudor Moisoiu

^1,2,3,

Matei Florin Negrut

^4,*,

Robert Simon

^1,5,6,

Alina Daciana Elec

¹,

Adriana Milena Muntean

¹,

Georgeta Horciag

¹,

Ana Maria Sitaru

⁷,

Andreea Liana Rachisan

⁸,

Gabriel Oniscu

⁹ and

Oana Antal

^1,5

¹

Clinical Institute of Urology and Renal Transplantation, 400006 Cluj-Napoca, Romania

²

Department of Urology, Iuliu Hațieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania

³

Biomed Data Analytics SRL, 400696 Cluj-Napoca, Romania

⁴

Faculty of Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania

⁵

Department of Anaesthesia and Intensive Care, Iuliu Hatieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania

⁶

Doctoral School, Faculty of Medicine, University of Oradea, 410073 Oradea, Romania

⁷

Department of Pediatrics, Iuliu Haţieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania

⁸

Department of Mother and Child, Discipline of Pediatrics II, Iuliu Hatieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania

⁹

Transplantation Surgery Division, Department of Clinical Science Intervention and Technology, Karolinska Institute, 141 86 Huddinge, Sweden

^*

Author to whom correspondence should be addressed.

J. Clin. Med. 2025, 14(10), 3540; https://doi.org/10.3390/jcm14103540

Submission received: 17 March 2025 / Revised: 6 May 2025 / Accepted: 14 May 2025 / Published: 18 May 2025

(This article belongs to the Special Issue Clinical Advances in Kidney Transplantation)

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Abstract

Background/Objectives: The Kidney Donor Profile Index (KDPI) is an important metric for evaluating the quality of donor kidneys and predicting post-transplant outcomes. The Estimated Post-Transplant Survival (EPTS) score is a tool for estimating kidney transplant candidates’ long-term survival. However, their validity in Eastern European cohorts is yet to be explored. This study aimed to evaluate the predictive accuracy of the KDPI and EPTS in a local cohort. Methods: We conducted a seven-year retrospective observational study at a high-volume transplant center in Romania. Data from 353 patients who received kidney transplants from brain-dead donors (DBDs) between 2017 and 2023 were analyzed. The KDPI scores were stratified into <35%, 35–85%, and >85%, while EPTS was stratified into <20%, 20–60%, and >60%. Primary outcomes included one-, three-, and five-year post-transplant graft function as estimated by eGFR, while secondary outcomes involved patient and graft survival rates at one, three, and five years. Results: Graft function and survival rates were significantly lower with increasing KDPI and EPTS scores, reinforcing the utility of both scores in clinical decision-making. Conclusions: Despite their limitations, KDPI and EPTS remain valuable predictors in our patient population.

Keywords: Kidney Donor Profile Index (KDPI); Estimated Post Transplant Survival (EPTS); predicting scoring system; organ allocation; transplant outcome

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MDPI and ACS Style

Elec, F.I.; Moisoiu, T.; Negrut, M.F.; Simon, R.; Elec, A.D.; Muntean, A.M.; Horciag, G.; Sitaru, A.M.; Rachisan, A.L.; Oniscu, G.; et al. Validation of Kidney Donor Profile Index and Estimated Post-Transplant Survival Scores in an Eastern European Transplantation Center—A Seven-Year Retrospective Observational Study. J. Clin. Med. 2025, 14, 3540. https://doi.org/10.3390/jcm14103540

AMA Style

Elec FI, Moisoiu T, Negrut MF, Simon R, Elec AD, Muntean AM, Horciag G, Sitaru AM, Rachisan AL, Oniscu G, et al. Validation of Kidney Donor Profile Index and Estimated Post-Transplant Survival Scores in an Eastern European Transplantation Center—A Seven-Year Retrospective Observational Study. Journal of Clinical Medicine. 2025; 14(10):3540. https://doi.org/10.3390/jcm14103540

Chicago/Turabian Style

Elec, Florin Ioan, Tudor Moisoiu, Matei Florin Negrut, Robert Simon, Alina Daciana Elec, Adriana Milena Muntean, Georgeta Horciag, Ana Maria Sitaru, Andreea Liana Rachisan, Gabriel Oniscu, and et al. 2025. "Validation of Kidney Donor Profile Index and Estimated Post-Transplant Survival Scores in an Eastern European Transplantation Center—A Seven-Year Retrospective Observational Study" Journal of Clinical Medicine 14, no. 10: 3540. https://doi.org/10.3390/jcm14103540

APA Style

Elec, F. I., Moisoiu, T., Negrut, M. F., Simon, R., Elec, A. D., Muntean, A. M., Horciag, G., Sitaru, A. M., Rachisan, A. L., Oniscu, G., & Antal, O. (2025). Validation of Kidney Donor Profile Index and Estimated Post-Transplant Survival Scores in an Eastern European Transplantation Center—A Seven-Year Retrospective Observational Study. Journal of Clinical Medicine, 14(10), 3540. https://doi.org/10.3390/jcm14103540

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Validation of Kidney Donor Profile Index and Estimated Post-Transplant Survival Scores in an Eastern European Transplantation Center—A Seven-Year Retrospective Observational Study

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