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Journal of Clinical Medicine, Volume 13, Issue 22

November-2 2024 - 373 articles

Cover Story: Patients with neck metastasis and no obvious primary tumor (NCUP) pose a diagnostic challenge. Many of these cases are p16-positive oropharyngeal squamous cell carcinomas (OPSCCs), often originating in the tonsils or base of the tongue. Early neck metastasis is likely due to the unique anatomy of the oropharynx. Identifying the primary tumor is crucial for treatment planning. However, imaging studies may not always be definitive. HPV testing can help localize the primary tumor, particularly in the oropharynx. Careful consideration of clinical, biomolecular, and morphological factors is essential for accurate prognosis and treatment, especially in HPV-positive patients with tobacco exposure or p53 mutations. View this paper
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Articles (373)

  • Systematic Review
  • Open Access
2 Citations
1,548 Views
12 Pages

20 November 2024

Introduction: The risk of asthma in patients with psoriasis and that of psoriasis in patients with asthma have increased, but relevant data for the pediatric population are lacking. Therefore, we performed a meta-analysis to assess the pooled associa...

  • Article
  • Open Access
5 Citations
3,279 Views
16 Pages

Resection of Early Colorectal Neoplasms Using Endoscopic Submucosal Dissection: A Retrospective Multicenter Cohort Study

  • Katarzyna Winter,
  • Przemysław Kasprzyk,
  • Zuzanna Nowicka,
  • Suzuki Noriko,
  • Alberto Herreros-de-Tejada and
  • Michał Spychalski

20 November 2024

Background: Endoscopic submucosal dissection (ESD) is a reliable method that can replace surgery in the treatment of early colorectal cancer under certain conditions. Aim: The aim of the study was to analyze factors influencing the ESD procedure in e...

  • Systematic Review
  • Open Access
1 Citations
1,779 Views
25 Pages

20 November 2024

Background/Objectives: Hemimandibular hyperplasia (HH) associated with osteochondroma presents complex challenges in maxillofacial surgery, including facial asymmetry, occlusal instability, and temporomandibular joint (TMJ) dysfunction. Surgical inte...

  • Article
  • Open Access
1,189 Views
9 Pages

20 November 2024

Objective: We aimed to determine whether the severity of acute Kawasaki disease (KD) can be predicted based on whether a patient remains febrile or becomes afebrile immediately after the completion of initial immunoglobulin treatment (IVIG). Methods:...

  • Article
  • Open Access
3 Citations
1,762 Views
15 Pages

Automated EEG-Based Brainwave Analysis for the Detection of Postoperative Delirium Does Not Result in a Shorter Length of Stay in Geriatric Hip Fracture Patients: A Multicentre Randomized Controlled Trial

  • Emma J. de Fraiture,
  • Henk Jan Schuijt,
  • Maryse Menninga,
  • Iris A. I. Koevoets,
  • Tessa F. M. Verheul,
  • Corine W. van Goor,
  • Thomas M. P. Nijdam,
  • Dieuwke. van Dartel,
  • Johannes H. Hegeman and
  • Detlef van der Velde

20 November 2024

Introduction: Delirium in postoperative geriatric hip fracture patients is a serious and often preventable condition. If detected in time, it can be treated, but a delay in the diagnosis and initiation of treatment impairs outcomes. A novel approach...

  • Article
  • Open Access
1 Citations
1,194 Views
9 Pages

Association Between Anaesthesiologists’ Sex and Anaesthesiology Quality Metrics and Postoperative Outcomes: A Retrospective Analysis

  • Sebastian Zeiner,
  • Mathias Maleczek,
  • Daniel Laxar,
  • Razvan Bologheanu,
  • Eva Schaden and
  • Oliver Kimberger

20 November 2024

Background: Evidence suggests differences in medical practice and patient outcomes between male and female physicians and surgeons. To date, no such relationships were investigated in anaesthesiologists. This study aimed to investigate an association...

  • Article
  • Open Access
1 Citations
1,187 Views
14 Pages

Anticoagulation Management for Veno-Venous ECMO in COVID-19 Patients: Argatroban as Rescue Therapy in Heparin-Associated Thrombocytopenia

  • Lorenzo Schiavoni,
  • Alessia Mattei,
  • Martina Cuccarelli,
  • Alessandro Strumia,
  • Carmelo Dominici,
  • Antonio Nenna,
  • Jessica Aceto,
  • Gloria Palazzo,
  • Giuseppe Pascarella and
  • Fabio Costa
  • + 3 authors

20 November 2024

Background/Objectives: Extracorporeal membrane oxygenation (ECMO) has been widely used as a life support technique in COVID-19 acute respiratory distress syndrome (ARDS). The use of anticoagulation during ECMO support remains a topic of debate. The p...

  • Article
  • Open Access
1 Citations
2,065 Views
11 Pages

A Therapeutic Proposal for Mini-Puberty in Male Infants with Hypogonadotropic Hypogonadism: A Retrospective Case Series

  • María Aurora Mesas-Aróstegui,
  • Fidel Hita-Contreras and
  • Juan Pedro López-Siguero

20 November 2024

Background: Male patients with congenital hypogonadotropic hypogonadism (CHH) have impaired postnatal activation of the hypothalamic–pituitary–gonadal axis that occurs during mini-puberty. The aim of this study was to report our experienc...

  • Systematic Review
  • Open Access
3 Citations
6,472 Views
22 Pages

20 November 2024

Background/Objectives: Light therapy has emerged as a promising non-pharmacological treatment for depressive symptoms. This meta-analysis aims to evaluate the effectiveness of light therapy specifically for depressive symptoms in elderly populations,...

  • Article
  • Open Access
2,142 Views
10 Pages

The Unmet Needs of Lysosomal Storage Disorders from Early Diagnosis to Caregiving Pathways: An Italian Perspective

  • Giancarlo Castaman,
  • Silvia Linari,
  • Antonio Barbato,
  • Niko Costantino,
  • Carlo Dionisi-Vici,
  • Francesca Menni,
  • Elena Procopio,
  • Silvia Ramat,
  • Fernanda Torquati and
  • Elena Verrecchia
  • + 1 author

20 November 2024

Background/Objective: Lysosomal storage diseases (LSDs) are a group of rare, inborn, metabolic errors characterized by deficiencies in normal lysosomal function and by the intralysosomal accumulation of undegraded substrates, resulting in the damage...

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J. Clin. Med. - ISSN 2077-0383