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Journal of Clinical Medicine, Volume 10, Issue 18

2021 September-2 - 255 articles

Cover Story: Adaptive splice regulators, such as RNA-binding motif protein 20 (RBM20) determine the physiological mRNA landscape formation, and rare variants in the RBM20 gene explain up to 6% of genetic dilated cardiomyopathy (DCM) cases. With ample knowledge from RBM20-deficient mice, rats, swine and induced pluripotent stem cells (iPSCs), the downstream targets and quantitative effects on splicing are now well-defined and the prerequisites for corrective therapeutic approaches are set. This review article highlights some of the recent advances in the field, ranging from aspects of granule formation to 3D genome architectures underlying RBM20-related cardiomyopathy. Promising therapeutic strategies are presented and put into context with the pathophysiological characteristics of RBM20-related diseases. View this paper
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Articles (255)

  • Review
  • Open Access
10 Citations
4,059 Views
11 Pages

21 September 2021

Vasospastic angina (VSA) is characterized by a reversible spasm of the coronary arteries and is more prevalent in Asians. Vasodilators, such as calcium channel blockers, are effective in relieving coronary spasms and preventing clinical events. There...

  • Article
  • Open Access
1 Citations
2,884 Views
11 Pages

Treatment of Pathologic Peritrochanteric Fractures Using Sliding Hip Screws Augmented with Cerclage Reconstruction Plates

  • Ying-Kuei Kuo,
  • Hsuan-Yu Chen,
  • Yuan-Fuu Lee,
  • Ting-Chun Huang,
  • Tsung-Han Yang,
  • Yu-An Chen and
  • Rong-Sen Yang

21 September 2021

We proposed a new method to augment the traditional sliding hip screw (SHS) with cerclage reconstruction plates to treat pathologically impending and actual peritrochanteric fractures as well as to revise open reductions and internal fixations to inc...

  • Article
  • Open Access
8 Citations
4,714 Views
15 Pages

21 September 2021

The posterior tibial slope of the tibiofemoral joint changes after medial open wedge high tibial osteotomy (MOWHTO), but little is known about the effect of the sagittal osteotomy inclination angle on the change in the posterior tibial slope of the t...

  • Review
  • Open Access
21 Citations
4,794 Views
14 Pages

Review: Influence of the CYP450 Genetic Variation on the Treatment of Psychotic Disorders

  • Lorena Carrascal-Laso,
  • María Isidoro-García,
  • Ignacio Ramos-Gallego and
  • Manuel A. Franco-Martín

21 September 2021

Second-generation antipsychotic metabolism is mainly carried out by the CYP450 superfamily, which is highly polymorphic. Therefore, knowing the influence of the different known CYP450 polymorphisms on antipsychotic plasmatic levels and, consequently,...

  • Review
  • Open Access
43 Citations
10,296 Views
19 Pages

Brain Correlates of Persistent Postural-Perceptual Dizziness: A Review of Neuroimaging Studies

  • Iole Indovina,
  • Luca Passamonti,
  • Viviana Mucci,
  • Giuseppe Chiarella,
  • Francesco Lacquaniti and
  • Jeffrey P. Staab

21 September 2021

Persistent postural-perceptual dizziness (PPPD), defined in 2017, is a vestibular disorder characterized by chronic dizziness that is exacerbated by upright posture and exposure to complex visual stimuli. This review focused on recent neuroimaging st...

  • Article
  • Open Access
1 Citations
4,062 Views
12 Pages

Effects of Whole-Body Vibration Training on Lower Limb Blood Flow in Children with Myelomeningocele—A Randomized Trial

  • Małgorzata Domagalska-Szopa,
  • Andrzej Szopa,
  • Andrzej Siwiec,
  • Ilona Kwiecień-Czerwieniec,
  • Lutz Schreiber and
  • Józefa Dąbek

21 September 2021

The objective of the present study was to determine the effectiveness of a three-week Whole-Body Vibration (WBV) training on the vascular blood flow of the lower limbs in children with myelomeningocele. The secondary goal was to evaluate the effect o...

  • Article
  • Open Access
14 Citations
5,350 Views
12 Pages

Early Diagnosis of Neutropenic Enterocolitis by Bedside Ultrasound in Hematological Malignancies: A Prospective Study

  • Edoardo Benedetti,
  • Benedetto Bruno,
  • Francesca Martini,
  • Riccardo Morganti,
  • Emilia Bramanti,
  • Francesco Caracciolo,
  • Sara Galimberti,
  • Piero Lippolis,
  • Emanuele Neri and
  • Mario Petrini
  • + 5 authors

21 September 2021

(1) Background: Neutropenic enterocolitis (NEC) is a life-threatening complication following chemotherapy with high mortality rates. Early diagnosis is crucial to improve outcomes. We designed a large prospective study employing bedside ultrasonograp...

  • Article
  • Open Access
44 Citations
8,288 Views
15 Pages

Ambulatory COVID-19 Patients Treated with Lactoferrin as a Supplementary Antiviral Agent: A Preliminary Study

  • Luigi Rosa,
  • Giovanni Tripepi,
  • Enrico Naldi,
  • Marina Aimati,
  • Stefano Santangeli,
  • Francesco Venditto,
  • Marcello Caldarelli and
  • Piera Valenti

21 September 2021

SARS-CoV-2, an enveloped, single-stranded RNA virus causing COVID-19, exerts morbidity and mortality especially in elderly, obese individuals and those suffering from chronic conditions. In addition to the availability of vaccines and the limited eff...

  • Article
  • Open Access
13 Citations
2,740 Views
11 Pages

Frailty Scales for Prognosis Assessment of Older Adult Patients after Acute Myocardial Infarction

  • Sergio García-Blas,
  • Clara Bonanad,
  • Agustín Fernández-Cisnal,
  • Clara Sastre-Arbona,
  • Maria-Arantzazu Ruescas-Nicolau,
  • Jessika González D’Gregorio,
  • Ernesto Valero,
  • Gema Miñana,
  • Patricia Palau and
  • Juan Sanchis
  • + 3 authors

21 September 2021

We aimed to compare the prognostic value of two different measures, the Fried’s Frailty Scale (FFS) and the Clinical Frailty Scale (CFS), following myocardial infarction (MI). We included 150 patients ≥ 70 years admitted from AMI. Frailty was evaluat...

  • Article
  • Open Access
4 Citations
3,035 Views
13 Pages

21 September 2021

This study evaluated the possibility of clinical remission suggested by the treat-to-target strategy and identified predictors of clinical remission in 139 patients with ankylosing spondylitis (AS) receiving tumor necrosis factor-α inhibitors (TNFi)....

  • Article
  • Open Access
31 Citations
4,115 Views
12 Pages

Diagnosis of Subclinical Keratoconus Based on Machine Learning Techniques

  • Gracia Castro-Luna,
  • Diana Jiménez-Rodríguez,
  • Ana Belén Castaño-Fernández and
  • Antonio Pérez-Rueda

21 September 2021

(1) Background: Keratoconus is a non-inflammatory corneal disease characterized by gradual thinning of the stroma, resulting in irreversible visual quality and quantity decline. Early detection of keratoconus and subsequent prevention of possible ris...

  • Article
  • Open Access
11 Citations
2,906 Views
11 Pages

Outbreaks of COVID-19 in Nursing Homes: A Cross-Sectional Survey of 74 Nursing Homes in a French Area

  • Emilie Piet,
  • Alexis Maillard,
  • Franck Olivier Mallaval,
  • Jean Yves Dusseau,
  • Murielle Galas-Haddad,
  • Sébastien Ducki,
  • Hélène Creton,
  • Marc Lallemant,
  • Emmanuel Forestier and
  • Tristan Delory
  • + 1 author

21 September 2021

In this multi-centric cross-sectional survey conducted in nursing homes of the French Alps, from 1 March to 31 May 2020, we analyze the relationship between the occurrence of an outbreak of COVID 19 among residents and staff members. Out of 225 eligi...

  • Article
  • Open Access
3 Citations
3,783 Views
14 Pages

Implicit and Explicit Memory in Youths with High-Functioning Autism Spectrum Disorder: A Case-Control Study

  • Elisa Fucà,
  • Giulia Lazzaro,
  • Floriana Costanzo,
  • Silvia Di Vara,
  • Deny Menghini and
  • Stefano Vicari

21 September 2021

Individuals with autism spectrum disorder (ASD) usually manifest heterogeneous impairments in their higher cognitive functions, including their implicit memory (IM) and explicit memory (EM). However, the findings on IM and EM in youths with ASD remai...

  • Article
  • Open Access
51 Citations
12,224 Views
11 Pages

Prevalence and Incidence of Osteoarthritis: A Population-Based Retrospective Cohort Study

  • Rola Hamood,
  • Matanya Tirosh,
  • Noga Fallach,
  • Gabriel Chodick,
  • Elon Eisenberg and
  • Omri Lubovsky

21 September 2021

While trends data of osteoarthritis (OA) are accumulating, primarily from Western Europe and the US, a gap persists in the knowledge of OA epidemiology in Middle Eastern populations. This study aimed to explore the prevalence, incidence, correlations...

  • Article
  • Open Access
1 Citations
3,297 Views
10 Pages

Using MRI Measurement to Improve Accuracy of Femoral Component Sizing in Oxford Unicompartmental Knee Arthroplasty

  • Cheng-Pang Yang,
  • Ying-Chieh Lai,
  • Chen-Te Wu,
  • Kung-Tseng Hung,
  • Yi-Sheng Chan,
  • Alvin Chao-Yu Chen and
  • Kuo-Yao Hsu

21 September 2021

Unicompartmental knee arthroplasty (UKA) can achieve better kinematics and faster recovery than total knee arthroplasty. The Phase III Oxford UKA system has five sizes of femoral components to approximate the normal knee geometry. However, these diff...

  • Article
  • Open Access
8 Citations
2,388 Views
9 Pages

Symptom Prevalence of Anxiety and Depression in Older Cardiac Arrest Survivors: A Comparative Nationwide Register Study

  • Kristofer Årestedt,
  • Johan Israelsson,
  • Ingrid Djukanovic,
  • Johan Herlitz,
  • Jörg Carlsson,
  • Suzanne Petersson and
  • Anders Bremer

21 September 2021

Knowledge about psychological distress in older cardiac arrest (CA) survivors is sparse, and the lack of comparisons with general populations make it difficult to draw any strong conclusions about prevalence and potential changes caused by CA. Our ai...

  • Article
  • Open Access
1 Citations
2,575 Views
13 Pages

Do Women Have a Higher Mortality Risk Than Men following ICU Admission after Out-of-Hospital Cardiac Arrest? A Retrospective Cohort Analysis

  • Christiaan van Wees,
  • Wim Rietdijk,
  • Loes Mandigers,
  • Marisa van der Graaf,
  • Niels T. B. Scholte,
  • Karst O. Adriaansens,
  • Remco C. M. van den Berg and
  • Corstiaan A. den Uil

21 September 2021

Purpose: previous studies showed that women have a higher mortality risk than men after out-of-hospital cardiac arrest (OHCA). This sex difference may disappear after adjustment for cardiac arrest characteristics. Most studies also included patients...

  • Review
  • Open Access
43 Citations
7,673 Views
16 Pages

Less Known Gastrointestinal Manifestations of Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome: A Systematic Review of the Literature

  • Djordje Jevtic,
  • Igor Dumic,
  • Terri Nordin,
  • Amteshwar Singh,
  • Nadezda Sulovic,
  • Milan Radovanovic,
  • Mladen Jecmenica and
  • Tamara Milovanovic

21 September 2021

Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a potentially life threatening severe cutaneous drug reaction. Most patients develop eosinophilia, a rash, a fever, lymphadenopathy and variable visceral organ involvement 2–6...

  • Article
  • Open Access
14 Citations
24,738 Views
10 Pages

Systemic Minoxidil Accidental Exposure in a Paediatric Population: A Case Series Study of Cutaneous and Systemic Side Effects

  • Manuel Sánchez-Díaz,
  • David López-Delgado,
  • Trinidad Montero-Vílchez,
  • Luis Salvador-Rodríguez,
  • Alejandro Molina-Leyva,
  • Jesús Tercedor-Sánchez and
  • Salvador Arias-Santiago

20 September 2021

Oral minoxidil is an approved treatment for high blood pressure which is also used as an off-label drug for alopecia. Knowledge about the effects of systemic minoxidil in the paediatric population is limited. A retrospective case series study of paed...

  • Article
  • Open Access
6 Citations
4,414 Views
13 Pages

20 September 2021

Objective: Signet-ring cell carcinoma (SRCC) is a rare histopathological subtype of colorectal cancer (CRC) constituting approximately 1% of CRC cases. This study analyzed the incidence and survival rates of colorectal SRCC. Methods: We analyzed the...

  • Article
  • Open Access
16 Citations
3,297 Views
9 Pages

Post-Mortem RT-PCR Assay for SARS-CoV-2 RNA in COVID-19 Patients’ Corneal Epithelium, Conjunctival and Nasopharyngeal Swabs

  • Francesco Aiello,
  • Marco Ciotti,
  • Gabriele Gallo Afflitto,
  • Maria Cristina Rapanotti,
  • Bartolo Caggiano,
  • Michele Treglia,
  • Sandro Grelli,
  • Sergio Bernardini,
  • Silvestro Mauriello and
  • Raffaele Mancino
  • + 2 authors

20 September 2021

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease has been described to possibly be associated with ocular surface disturbances. However, whether the virus could invade ocular tissues still remains elusive. In the present study, we...

  • Review
  • Open Access
17 Citations
4,745 Views
10 Pages

Technological Advancements in Male Infertility Microsurgery

  • Nahid Punjani,
  • Caroline Kang,
  • Richard K. Lee,
  • Marc Goldstein and
  • Philip S. Li

20 September 2021

There have been significant advancements in male infertility microsurgery over time, and there continues to be significant promise for new and emerging techniques, technologies, and methodologies. In this review, we discuss the history of male infert...

  • Article
  • Open Access
22 Citations
4,831 Views
10 Pages

Effects of Dry Needling in Teres Major Muscle in Elite Handball Athletes. A Randomised Controlled Trial

  • Luis Ceballos-Laita,
  • Ricardo Medrano-de-la-Fuente,
  • Elena Estébanez-De-Miguel,
  • Jorge Moreno-Cerviño,
  • María Teresa Mingo-Gómez,
  • Ignacio Hernando-Garijo and
  • Sandra Jiménez-del-Barrio

20 September 2021

Objective: To determine the effects of dry needling (DN) in active myofascial trigger points in the teres major muscle compared to an untreated control group in pain during throwing actions, shoulder range of motion (ROM), strength, and extensibility...

  • Article
  • Open Access
3 Citations
4,187 Views
14 Pages

Epidermal-Derived Hedgehog Signaling Drives Mesenchymal Proliferation during Digit Tip Regeneration

  • Zeshaan N. Maan,
  • Yuval Rinkevich,
  • Janos Barrera,
  • Kellen Chen,
  • Dominic Henn,
  • Deshka Foster,
  • Clark Andrew Bonham,
  • Jagannath Padmanabhan,
  • Dharshan Sivaraj and
  • Geoffrey C. Gurtner
  • + 6 authors

20 September 2021

Hand injuries often result in significant functional impairments and are rarely completely restored. The spontaneous regeneration of injured appendages, which occurs in salamanders and newts, for example, has been reported in human fingertips after d...

  • Article
  • Open Access
16 Citations
4,050 Views
18 Pages

Resilience, Emotional Intelligence, and Occupational Performance in Family Members Who Are the Caretakers of Patients with Dementia in Spain: A Cross-Sectional, Analytical, and Descriptive Study

  • María Nieves Gómez-Trinidad,
  • Carlos Alexis Chimpén-López,
  • Laura Rodríguez-Santos,
  • Manuel Alfredo Moral and
  • Juan Rodríguez-Mansilla

20 September 2021

Background: The concern in the scientific community for the study of people with dementia and their families is comprehensible, especially the importance of knowing the effects that caring for the patient has on their family dynamic, paying special a...

  • Article
  • Open Access
10 Citations
5,387 Views
10 Pages

20 September 2021

We aim to investigate the significance of intravesical prostate protrusion (IPP) on the prognosis of non-muscle invasive bladder cancer (NMIBC) after the transurethral resection of bladder tumors (TURBT). For newly diagnosed NMIBC, we retrospectively...

  • Review
  • Open Access
14 Citations
4,973 Views
14 Pages

20 September 2021

As an element of distorted self-image, body image disturbances may be relevant to borderline personality disorder (BPD). Therefore, this systematic review aims to critically discuss and summarize empirical findings in this matter. Based on the availa...

  • Article
  • Open Access
3 Citations
3,306 Views
14 Pages

Association of Infliximab and Vedolizumab Trough Levels with Reported Rates of Adverse Events: A Cross-Sectional Study

  • Ido Veisman,
  • Oranit Barzilay,
  • Liora Bruckmayer,
  • Ola Haj-Natour,
  • Uri Kopylov,
  • Rami Eliakim,
  • Shomron Ben-Horin and
  • Bella Ungar

20 September 2021

Infliximab and vedolizumab are effective treatments for inflammatory bowel disease (IBD), although associated with adverse events (AE). While low or non-existent drug levels and positive antidrug antibodies have been associated with therapeutic failu...

  • Article
  • Open Access
6 Citations
2,858 Views
12 Pages

20 September 2021

Real-world data report worse 3-month clinical outcomes in elderly patients with acute ischemic stroke (AIS) treated with mechanical thrombectomy (MT). The aim was to identify factors influencing clinical outcome in elderly patients with anterior circ...

  • Article
  • Open Access
13 Citations
10,048 Views
9 Pages

20 September 2021

The incidence of pelvic organ prolapse (POP) is increasing in our aging society. We aimed to evaluate the clinical usefulness of translabial ultrasound (TLUS) by comparing the findings of POP-Q examination and TLUS in advanced POP patients and we als...

  • Review
  • Open Access
5 Citations
3,598 Views
9 Pages

How Close Are We toward an Optimal Balance in Safety and Efficacy in Catheter Ablation of Atrial Fibrillation? Lessons from the CLOSE Protocol

  • Michelle Lycke,
  • Louisa O’Neill,
  • Kris Gillis,
  • Jean-Yves Wielandts,
  • Jean-Benoit Le Polain De Waroux,
  • Rene Tavernier,
  • Sebastien Knecht and
  • Mattias Duytschaever

20 September 2021

Catheter ablation for atrial fibrillation (AF) is a common treatment strategy in patients with drug-resistant, symptomatic AF. In patients with paroxysmal and short-standing persistent AF, pulmonary vein isolation (PVI) is often enough to prevent rec...

  • Review
  • Open Access
6 Citations
4,357 Views
12 Pages

Sepsis and Cognitive Assessment

  • Laura C. Jones,
  • Catherine Dion,
  • Philip A. Efron and
  • Catherine C. Price

20 September 2021

Sepsis disproportionally affects people over the age of 65, and with an exponentially increasing older population, sepsis poses additional risks for cognitive decline. This review summarizes published literature for (1) authorship qualification; (2)...

  • Review
  • Open Access
4 Citations
7,184 Views
9 Pages

Management of Pleural Effusion Secondary to Malignant Mesothelioma

  • Valeria Musso,
  • Cristina Diotti,
  • Alessandro Palleschi,
  • Davide Tosi,
  • Alberto Aiolfi and
  • Paolo Mendogni

19 September 2021

Malignant pleural mesothelioma (MPM) is a highly aggressive pleural tumour which has been epidemiologically linked to occupational exposure to asbestos. MPM is often associated with pleural effusion, which is a common cause of morbidity and whose man...

  • Review
  • Open Access
20 Citations
6,377 Views
27 Pages

The Role of Neuropeptides in Pathogenesis of Dry Eye

  • Daniel Duck-Jin Hwang,
  • Seok-Jae Lee,
  • Jeong-Hun Kim and
  • Sang-Mok Lee

19 September 2021

Neuropeptides are known as important mediators between the nervous and immune systems. Recently, the role of the corneal nerve in the pathogenesis of various ocular surface diseases, including dry eye disease, has been highlighted. Neuropeptides are...

  • Article
  • Open Access
4 Citations
2,555 Views
9 Pages

19 September 2021

Background: To evaluate whether short-term use of topical steroid therapy affected the efficacy of selective laser trabeculoplasty (SLT) for primary open-glaucoma (POAG). Methods: 25 eyes of 25 patients, who used a drop of dexamethasone 0.1% 4 times...

  • Review
  • Open Access
29 Citations
9,353 Views
12 Pages

Reticulocyte and Erythrocyte Hemoglobin Parameters for Iron Deficiency and Anemia Diagnostics in Patient Blood Management. A Narrative Review

  • Christian Hoenemann,
  • Norbert Ostendorf,
  • Alexander Zarbock,
  • Dietrich Doll,
  • Olaf Hagemann,
  • Mathias Zimmermann and
  • Markus Luedi

19 September 2021

Anemia, iron deficiency and other hematinic deficiencies are a major cause of perioperative transfusion needs and are associated with increased morbidity and mortality. Anemia can be caused either by decreased production of hemoglobin or red blood ce...

  • Article
  • Open Access
11 Citations
3,030 Views
10 Pages

Initial Results after the Implementation of an Edge-To-Edge Transcatheter Tricuspid Valve Repair Program

  • Pedro Luis Cepas-Guillen,
  • Juan Carlos de la Fuente Mancera,
  • Joan Guzman Bofarull,
  • Marta Farrero,
  • Ander Regueiro,
  • Salvatore Brugaletta,
  • Cristina Ibañez,
  • Laura Sanchis,
  • Marta Sitges and
  • Xavier Freixa
  • + 1 author

19 September 2021

Transcatheter tricuspid valve repair (TTVr) has emerged as an alternative for the treatment of severe tricuspid regurgitation (TR). We report our initial experience with an edge-to-edge TTVr system in a high-volume institution. Methods: We included c...

  • Article
  • Open Access
13 Citations
3,313 Views
14 Pages

Sex Differences in Chronic Thromboembolic Pulmonary Hypertension. Treatment Options over Time in a National Referral Center

  • Alejandro Cruz-Utrilla,
  • María José Cristo-Ropero,
  • Miguel Calderón-Flores,
  • Maite Velázquez,
  • María Jesús López-Gude,
  • Yolanda Revilla Ostolaza,
  • José Luis Pérez Vela,
  • Javier de la Cruz-Bértolo,
  • Héctor Bueno and
  • Pilar Escribano-Subias
  • + 2 authors

19 September 2021

(1) Background: Clinical presentation, disease distribution, or treatment received may provide insights into the reasons contributing to sex differences in chronic thromboembolic pulmonary hypertension (CTEPH). (2) Methods: We evaluated 453 patients...

  • Article
  • Open Access
1 Citations
1,960 Views
9 Pages

Urinary Levels of Cathepsin B in Preterm Newborns

  • Monika Kamianowska,
  • Marek Szczepański,
  • Anna Krukowska,
  • Aleksandra Kamianowska and
  • Anna Wasilewska

19 September 2021

Increased investment in perinatal health in developing countries has improved the survival of preterm newborns, but their significant multiorgan immaturity is associated with short and long-term adverse consequences. Cathepsin B, as a protease with a...

  • Article
  • Open Access
5 Citations
4,007 Views
13 Pages

Executive Function and Sensory Processing in Dichotic Listening of Young Adults with Listening Difficulties

  • Aline Tocchini Pascoinelli,
  • Eliane Schochat and
  • Cristina Ferraz Borges Murphy

19 September 2021

Previous studies have suggested that varying attention demands in dichotic listening (DL) tasks might be a clinically feasible method to distinguish ‘bottom-up’ from ‘top-down’ deficits in listening. This study aims to investigate DL processing in ad...

  • Article
  • Open Access
4 Citations
3,229 Views
10 Pages

Wide-Field Swept-Source OCT Analysis of Interocular Symmetry of Choroidal Thickness in Subjects with Uncomplicated Pachychoroid

  • Min-Su Kim,
  • Hyung-Bin Lim,
  • Woo-Hyuk Lee,
  • Yeo-Kyoung Won,
  • Ki-Yup Nam and
  • Jung-Yeul Kim

19 September 2021

Background: We aimed to study the bilateral choroidal thickness (CT) symmetry and difference in uncomplicated pachychoroid subjects using wide-field swept-source optical coherence tomography (SS-OCT). Methods: All subjects underwent a wide-field 16-m...

  • Article
  • Open Access
5 Citations
2,260 Views
11 Pages

18 September 2021

Purpose: The aim of this study is to investigate the structure–function characteristics and vision-related quality of life (VR-QoL) in uveitic glaucoma (UG) compared with open-angle glaucoma (OAG). Method: The study included 69 patients with UG and 1...

  • Review
  • Open Access
59 Citations
9,537 Views
22 Pages

Epidemiology of Stroke in Sickle Cell Disease

  • Fenella Jane Kirkham and
  • Ikeoluwa A. Lagunju

18 September 2021

Sickle cell disease is the most common cause of stroke in childhood, both ischaemic and haemorrhagic, and it also affects adults with the condition. Without any screening or preventative treatment, the incidence appears to fall within the range 0.5 t...

  • Review
  • Open Access
12 Citations
11,328 Views
12 Pages

Serous Borderline Ovarian Tumor Diagnosis, Management and Fertility Preservation in Young Women

  • Marie Carbonnel,
  • Laetitia Layoun,
  • Marine Poulain,
  • Morgan Tourne,
  • Rouba Murtada,
  • Michael Grynberg,
  • Anis Feki and
  • Jean Marc Ayoubi

18 September 2021

Borderline ovarian tumors (BOT) represent about 10 to 20 percent of all epithelial tumors of the ovary. They constitute intermediate lesions between benign ovarian cysts and invasive carcinomas. They often occur in young women of reproductive age, an...

  • Review
  • Open Access
18 Citations
3,972 Views
14 Pages

Aortic Valve Stenosis and Cardiac Amyloidosis: A Misleading Association

  • Andrea Bonelli,
  • Sara Paris,
  • Matilde Nardi,
  • Michael Y. Henein,
  • Eustachio Agricola,
  • Giovanni Troise and
  • Pompilio Faggiano

18 September 2021

The association between aortic stenosis (AS) and cardiac amyloidosis (CA) is more frequent than expected. Albeit rare, CA, particularly the transthyretin (ATTR) form, is commonly found in elderly people. ATTR-CA is also the most prevalent form in pat...

  • Review
  • Open Access
41 Citations
8,274 Views
22 Pages

Fertility-Sparing Surgery for Ovarian Cancer

  • Geoffroy Canlorbe,
  • Nathalie Chabbert-Buffet and
  • Catherine Uzan

18 September 2021

(1) Background: although most patients with epithelial ovarian cancer (EOC) undergo radical surgery, patients with early-stage disease, borderline ovarian tumor (BOT) or a non-epithelial tumor could be offered fertility-sparing surgery (FSS) dependin...

  • Article
  • Open Access
8 Citations
3,745 Views
10 Pages

Hypertriglyceridemia Is Associated with More Severe Histological Glomerulosclerosis in IgA Nephropathy

  • Won Jung Choi,
  • Yu Ah Hong,
  • Ji Won Min,
  • Eun Sil Koh,
  • Hyung Duk Kim,
  • Tae Hyun Ban,
  • Young Soo Kim,
  • Yong Kyun Kim,
  • Seok Joon Shin and
  • Yoon-Kyung Chang
  • + 2 authors

18 September 2021

IgA nephropathy (IgAN) is a globally well-known primary glomerular nephropathy. Hypertriglyceridemia (HTG) is one factor contributing to atherosclerosis and is a common complication of renal failure. HTG is a significant risk factor for decreased ren...

  • Article
  • Open Access
9 Citations
5,805 Views
13 Pages

The Effect of Submaximal Exercise Followed by Short-Term Cold-Water Immersion on the Inflammatory State in Healthy Recreational Athletes: A Cross-Over Study

  • Marta Pawłowska,
  • Celestyna Mila-Kierzenkowska,
  • Tomasz Boraczyński,
  • Michał Boraczyński,
  • Karolina Szewczyk-Golec,
  • Paweł Sutkowy,
  • Roland Wesołowski,
  • Małgorzata Smoguła and
  • Alina Woźniak

18 September 2021

Cold-water immersion (CWI) after exercise is a method used by sportsmen to improve recovery. The aim of the study was to assess the effect of a 3 min CWI on the inflammatory state by measuring levels of interleukin 6 (IL-6), interleukin 10 (IL-10), t...

  • Article
  • Open Access
10 Citations
6,235 Views
11 Pages

Running after Activated Clotting Time Values in Patients Receiving Direct Oral Anticoagulants: A Potentially Dangerous Race. Results from a Prospective Study in Atrial Fibrillation Catheter Ablation Procedures

  • Karim Benali,
  • Julien Verain,
  • Nefissa Hammache,
  • Charles Guenancia,
  • Darren Hooks,
  • Isabelle Magnin-Poull,
  • Marie Toussaint-Hacquard,
  • Christian de Chillou and
  • Jean-Marc Sellal

18 September 2021

Background: Activated Clotting Time (ACT) guided heparinization is the gold standard for titrating unfractionated heparin (UFH) administration during atrial fibrillation (AF) ablation procedures. The current ACT target (300 s) is based on studies in...

  • Article
  • Open Access
14 Citations
3,918 Views
14 Pages

Arterial Stiffness Assessment Using the Arteriograph in Patients with Moderate–Severe OSA and Metabolic Syndrome—A Pilot Study

  • Ioana Mădălina Zota,
  • Cristian Stătescu,
  • Radu Andy Sascău,
  • Mihai Roca,
  • Larisa Anghel,
  • Ovidiu Mitu,
  • Cristina Mihaela Ghiciuc,
  • Daniela Boisteanu,
  • Razvan Anghel and
  • Florin Mitu
  • + 2 authors

18 September 2021

Background: Both obstructive sleep apnea (OSA) and metabolic syndrome (MS) promote arterial stiffening. As a basis for this study, we presumed that arterial stiffness could be assessed using the Arteriograph (TensioMed, Budapest, Hungary) to detect e...

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J. Clin. Med. - ISSN 2077-0383