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Journal of Clinical Medicine, Volume 10, Issue 18

September-2 2021 - 255 articles

Cover Story: Adaptive splice regulators, such as RNA-binding motif protein 20 (RBM20) determine the physiological mRNA landscape formation, and rare variants in the RBM20 gene explain up to 6% of genetic dilated cardiomyopathy (DCM) cases. With ample knowledge from RBM20-deficient mice, rats, swine and induced pluripotent stem cells (iPSCs), the downstream targets and quantitative effects on splicing are now well-defined and the prerequisites for corrective therapeutic approaches are set. This review article highlights some of the recent advances in the field, ranging from aspects of granule formation to 3D genome architectures underlying RBM20-related cardiomyopathy. Promising therapeutic strategies are presented and put into context with the pathophysiological characteristics of RBM20-related diseases. View this paper
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Articles (255)

  • Review
  • Open Access
7 Citations
3,667 Views
11 Pages

21 September 2021

Vasospastic angina (VSA) is characterized by a reversible spasm of the coronary arteries and is more prevalent in Asians. Vasodilators, such as calcium channel blockers, are effective in relieving coronary spasms and preventing clinical events. There...

  • Article
  • Open Access
1 Citations
2,769 Views
11 Pages

Treatment of Pathologic Peritrochanteric Fractures Using Sliding Hip Screws Augmented with Cerclage Reconstruction Plates

  • Ying-Kuei Kuo,
  • Hsuan-Yu Chen,
  • Yuan-Fuu Lee,
  • Ting-Chun Huang,
  • Tsung-Han Yang,
  • Yu-An Chen and
  • Rong-Sen Yang

21 September 2021

We proposed a new method to augment the traditional sliding hip screw (SHS) with cerclage reconstruction plates to treat pathologically impending and actual peritrochanteric fractures as well as to revise open reductions and internal fixations to inc...

  • Article
  • Open Access
6 Citations
4,461 Views
15 Pages

21 September 2021

The posterior tibial slope of the tibiofemoral joint changes after medial open wedge high tibial osteotomy (MOWHTO), but little is known about the effect of the sagittal osteotomy inclination angle on the change in the posterior tibial slope of the t...

  • Review
  • Open Access
20 Citations
4,448 Views
14 Pages

Review: Influence of the CYP450 Genetic Variation on the Treatment of Psychotic Disorders

  • Lorena Carrascal-Laso,
  • María Isidoro-García,
  • Ignacio Ramos-Gallego and
  • Manuel A. Franco-Martín

21 September 2021

Second-generation antipsychotic metabolism is mainly carried out by the CYP450 superfamily, which is highly polymorphic. Therefore, knowing the influence of the different known CYP450 polymorphisms on antipsychotic plasmatic levels and, consequently,...

  • Review
  • Open Access
39 Citations
9,578 Views
19 Pages

Brain Correlates of Persistent Postural-Perceptual Dizziness: A Review of Neuroimaging Studies

  • Iole Indovina,
  • Luca Passamonti,
  • Viviana Mucci,
  • Giuseppe Chiarella,
  • Francesco Lacquaniti and
  • Jeffrey P. Staab

21 September 2021

Persistent postural-perceptual dizziness (PPPD), defined in 2017, is a vestibular disorder characterized by chronic dizziness that is exacerbated by upright posture and exposure to complex visual stimuli. This review focused on recent neuroimaging st...

  • Article
  • Open Access
1 Citations
3,774 Views
12 Pages

Effects of Whole-Body Vibration Training on Lower Limb Blood Flow in Children with Myelomeningocele—A Randomized Trial

  • Małgorzata Domagalska-Szopa,
  • Andrzej Szopa,
  • Andrzej Siwiec,
  • Ilona Kwiecień-Czerwieniec,
  • Lutz Schreiber and
  • Józefa Dąbek

21 September 2021

The objective of the present study was to determine the effectiveness of a three-week Whole-Body Vibration (WBV) training on the vascular blood flow of the lower limbs in children with myelomeningocele. The secondary goal was to evaluate the effect o...

  • Article
  • Open Access
12 Citations
4,981 Views
12 Pages

Early Diagnosis of Neutropenic Enterocolitis by Bedside Ultrasound in Hematological Malignancies: A Prospective Study

  • Edoardo Benedetti,
  • Benedetto Bruno,
  • Francesca Martini,
  • Riccardo Morganti,
  • Emilia Bramanti,
  • Francesco Caracciolo,
  • Sara Galimberti,
  • Piero Lippolis,
  • Emanuele Neri and
  • Chiara Arena
  • + 5 authors

21 September 2021

(1) Background: Neutropenic enterocolitis (NEC) is a life-threatening complication following chemotherapy with high mortality rates. Early diagnosis is crucial to improve outcomes. We designed a large prospective study employing bedside ultrasonograp...

  • Article
  • Open Access
41 Citations
8,026 Views
15 Pages

Ambulatory COVID-19 Patients Treated with Lactoferrin as a Supplementary Antiviral Agent: A Preliminary Study

  • Luigi Rosa,
  • Giovanni Tripepi,
  • Enrico Naldi,
  • Marina Aimati,
  • Stefano Santangeli,
  • Francesco Venditto,
  • Marcello Caldarelli and
  • Piera Valenti

21 September 2021

SARS-CoV-2, an enveloped, single-stranded RNA virus causing COVID-19, exerts morbidity and mortality especially in elderly, obese individuals and those suffering from chronic conditions. In addition to the availability of vaccines and the limited eff...

  • Article
  • Open Access
12 Citations
2,600 Views
11 Pages

Frailty Scales for Prognosis Assessment of Older Adult Patients after Acute Myocardial Infarction

  • Sergio García-Blas,
  • Clara Bonanad,
  • Agustín Fernández-Cisnal,
  • Clara Sastre-Arbona,
  • Maria-Arantzazu Ruescas-Nicolau,
  • Jessika González D’Gregorio,
  • Ernesto Valero,
  • Gema Miñana,
  • Patricia Palau and
  • Francisco J. Tarazona-Santabalbina
  • + 3 authors

21 September 2021

We aimed to compare the prognostic value of two different measures, the Fried’s Frailty Scale (FFS) and the Clinical Frailty Scale (CFS), following myocardial infarction (MI). We included 150 patients ≥ 70 years admitted from AMI. Frailty was evaluat...

  • Article
  • Open Access
4 Citations
2,799 Views
13 Pages

21 September 2021

This study evaluated the possibility of clinical remission suggested by the treat-to-target strategy and identified predictors of clinical remission in 139 patients with ankylosing spondylitis (AS) receiving tumor necrosis factor-α inhibitors (TNFi)....

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J. Clin. Med. - ISSN 2077-0383