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Volume 7
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10.3390/vaccines7040203
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Review

Considering Genomic and Immunological Correlates of Protection for a Dengue Intervention

by
Joshua Blight
1,2,
Eduardo Alves
1,2 and
Arturo Reyes-Sandoval
2,*
1
Department of Life Sciences, Imperial College London, Sir Alexander Fleming Building, Exhibition Road, South Kensington, London SW7 2AZ, UK
2
The Jenner Institute, Nuffield Department of Medicine, University of Oxford, The Henry Wellcome Building for Molecular Physiology, Roosevelt Drive, Oxford OX3 7BN, UK
*
Author to whom correspondence should be addressed.
Vaccines 2019, 7(4), 203; https://doi.org/10.3390/vaccines7040203
Submission received: 31 October 2019 / Revised: 25 November 2019 / Accepted: 27 November 2019 / Published: 3 December 2019
(This article belongs to the Special Issue Arbovirus Vaccines That Circulate within the Same Ecological Niche: Zika, Dengue & Chikungunya)
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Abstract

Over three billion are at risk of dengue infection with more than 100 million a year presenting with symptoms that can lead to deadly haemorrhagic disease. There are however no treatments available and the only licensed vaccine shows limited efficacy and is able to enhance the disease in some cases. These failures have mainly been due to the complex pathology and lack of understanding of the correlates of protection for dengue virus (DENV) infection. With increasing data suggesting both a protective and detrimental effect for antibodies and CD8 T-cells whilst having complex environmental dynamics. This review discusses the roles of genomic and immunological aspects of DENV infection, providing both a historical interpretation and fresh discussion on how this information can be used for the next generation of dengue interventions.
Keywords: dengue; DENV; genomic variation; genomic diversity; T-cell responses; antibody responses; vaccines dengue; DENV; genomic variation; genomic diversity; T-cell responses; antibody responses; vaccines

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MDPI and ACS Style

Blight, J.; Alves, E.; Reyes-Sandoval, A. Considering Genomic and Immunological Correlates of Protection for a Dengue Intervention. Vaccines 2019, 7, 203. https://doi.org/10.3390/vaccines7040203

AMA Style

Blight J, Alves E, Reyes-Sandoval A. Considering Genomic and Immunological Correlates of Protection for a Dengue Intervention. Vaccines. 2019; 7(4):203. https://doi.org/10.3390/vaccines7040203

Chicago/Turabian Style

Blight, Joshua, Eduardo Alves, and Arturo Reyes-Sandoval. 2019. "Considering Genomic and Immunological Correlates of Protection for a Dengue Intervention" Vaccines 7, no. 4: 203. https://doi.org/10.3390/vaccines7040203

APA Style

Blight, J., Alves, E., & Reyes-Sandoval, A. (2019). Considering Genomic and Immunological Correlates of Protection for a Dengue Intervention. Vaccines, 7(4), 203. https://doi.org/10.3390/vaccines7040203

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