Correction: Omole et al. Safety, Tolerability, and Immunogenicity of the Pneumococcal Vaccines PPSV23 or PCV15 Co-Administered with a Booster Dose of mRNA-1273 SARS-CoV-2 Vaccine in Healthy Adults ≥50 Years of Age. Vaccines 2025, 13, 192
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1
Merck & Co., Inc., Rahway, NJ 07065, USA
2
Advanced Medical Research Institute, Miami, FL 33174, USA
The authors would like to make the following corrections to this published paper [1].
In the original publication, there was a typographical error in the footnote for Table 1. Information in footnotes indicating previous receipt of non-study vaccines in the PPSV23 and PCV15 groups was reversed. The footnote indicated with † has been changed from “A participant in the PPSV23 sequential group had previously received an inactivated vaccine for influenza” to “A participant in the PPSV23 sequential group had previously received a vaccine for tetanus”. The footnote indicated with ‡ has been changed from “A participant in the PCV15 group had previously received a vaccine for tetanus” to “A participant in the PCV15 group had previously received an inactivated vaccine for influenza”. The corrected Table 1 appears below.
Table 1.
Baseline characteristics and demographics.
In the original publication, there were typographical errors in the population sizes for the PCV15 concomitant and PCV15 sequential groups in Table 2. The population size for the PCV15 concomitant group has been changed from “n = 211” to “n = 210”, and population size for the PCV15 sequential group has been changed from “n = 211” to “n = 208”. The corrected Table 2 appears below.
Table 2.
Primary immunogenicity endpoint: serotype-specific OPA responses at 30 days post-vaccination.
The authors state that the scientific conclusions are unaffected. This correction was approved by the Academic Editor. The original publication has also been updated.
Reference
Omole, T.; Pelayo, E.; Weinberg, A.S.; Chalkias, S.; Endale, Z.; Tamms, G.; Sterling, T.M.; Good, L.; Shekar, T.; Johnson, M.; et al. Safety, Tolerability, and Immunogenicity of the Pneumococcal Vaccines PPSV23 or PCV15 Co-Administered with a Booster Dose of mRNA-1273 SARS-CoV-2 Vaccine in Healthy Adults ≥50 Years of Age. Vaccines2025, 13, 192. [Google Scholar] [CrossRef] [Scilit] [PubMed]
Table 1.
Baseline characteristics and demographics.
Table 1.
Baseline characteristics and demographics.
Participants in Population
PPSV23 Concomitant Group (n = 214)
PPSV23 Sequential Group (n = 211)
PCV15 Concomitant Group (n = 210)
PCV15 Sequential Group (n = 208)
Sex, n (%)
Male
107 (50.0)
80 (37.9)
98 (46.7)
78 (37.5)
Female
107 (50.0)
131 (62.1)
112 (53.3)
130 (62.5)
Mean age, years (range)
60.5 (50–93)
60.5 (50–89)
60.5 (50–88)
60.4 (50–86)
Age category
50–64 years
158 (73.8)
155 (73.5)
153 (72.9)
153 (73.6)
65–74 years
41 (19.2)
42 (19.9)
43 (20.5)
43 (20.7)
≥75 years
15 (7.0)
14 (6.6)
14 (6.7)
12 (5.8)
Race, n (%)
White
164 (76.6)
173 (82.0)
163 (77.6)
157 (75.5)
Black or African American
41 (19.2)
32 (15.2)
36 (17.1)
40 (19.2)
Asian
4 (1.9)
3 (1.4)
7 (3.3)
4 (1.9)
Multiple
5 (2.3)
3 (1.4)
3 (1.4)
5 (2.4)
American Indian or Alaska Native
0
0
1 (0.5)
2 (1.0)
Ethnicity, n (%)
Not Hispanic or Latino
127 (59.3)
111 (52.6)
122 (58.1)
116 (55.8)
Hispanic or Latino
87 (40.7)
98 (46.4)
88 (41.9)
91 (43.8)
Not reported
0
2 (0.9)
0
1 (0.5)
Prior medications, n (%)
At least one prior medication
154 (72.0)
162 (76.8)
160 (76.2)
148 (71.2)
No prior medication
60 (28.0)
49 (23.2)
50 (23.8)
60 (28.8)
Prior vaccinations, n (%)
At least one prior vaccination
0
1 (0.5) †
1 (0.5) ‡
0
No prior vaccinations
214 (100.0)
210 (99.5)
209 (99.5)
208 (100.0)
Concomitant medications, n (%)
At least one concomitant medication
164 (76.6)
173 (82.0)
167 (79.5)
162 (77.9)
No concomitant medications
50 (23.4)
38 (18.0)
43 (20.5)
46 (22.1)
Concomitant vaccinations, n (%)
At least one concomitant vaccination
4 (1.9)
1 (0.5)
7 (3.3)
4 (1.9)
No concomitant vaccinations
210 (98.1)
210 (99.5)
203 (96.7)
204 (98.1)
Each participant is counted once per parameter. † A participant in the PPSV23 sequential group had previously received a vaccine for tetanus. ‡ A participant in the PCV15 group had previously received an inactivated vaccine for influenza. PCV15: 15-valent pneumococcal conjugate vaccine; PPSV23: 23-valent pneumococcal polysaccharide vaccine.
Table 2.
Primary immunogenicity endpoint: serotype-specific OPA responses at 30 days post-vaccination.
Table 2.
Primary immunogenicity endpoint: serotype-specific OPA responses at 30 days post-vaccination.
PPSV23 Concomitant Group (n = 214)
PPSV23 Sequential Group (n = 211)
PCV15 Concomitant Group (n = 210)
PCV15 Sequential Group (n = 208)
Pneumococcal Serotype
n
Observed Response (95% CI) †
n
Observed Response (95% CI) †
n
Observed Response (95% CI) †
n
Observed Response (95% CI) †
1
182
236.0 (177.0–314.6)
177
253.5 (188.4–341.1)
186
208.3 (160.8–269.9)
174
265.6 (203.4–346.7)
3
167
174.3 (138.6–219.2)
164
284.0 (224.1–359.9)
174
237.5 (197.5–285.6)
155
338.4 (275.3–416.0)
4
182
1384.5 (1110.7–1725.9)
165
1704.4 (1370.6–2119.5)
181
1586.0 (1296.5–1940.2)
176
1758.6 (1419.4–2178.8)
5
189
423.4 (324.9–551.7)
181
376.3 (282.6–501.2)
190
447.0 (341.7–584.8)
180
505.5 (382.7–667.8)
6A
–
–
–
–
176
4345.3 (3490.0–5410.1)
162
5787.1 (4468.4–7495.0)
6B
182
1336.7 (1038.2–1721.1)
171
1326.8 (1016.7–1731.4)
173
3655.5 (2939.1–4546.6)
158
4992.9 (3896.2–6398.2)
7F
184
2614.4 (2123.8–3218.4)
174
2420.2 (1919.6–3051.3)
187
3465.7 (2858.7–4201.6)
170
3283.0 (2664.3–4045.4)
9V
185
1651.1 (1352.0–2016.4)
174
1809.2 (1502.2–2179.0)
187
1730.3 (1432.7–2089.8)
166
2026.6 (1651.0–2487.5)
14
184
3048.3 (2429.0–3825.5)
176
2618.4 (2078.8–3298.1)
186
2487.2 (2026.1–3053.2)
177
2460.8 (2018.4–3000.3)
18C
188
1592.9 (1281.0–1980.7)
179
2033.7 (1639.6–2522.5)
187
3144.5 (2597.3–3806.8)
171
3183.5 (2587.9–3916.2)
19A
185
2135.7 (1761.7–2589.2)
169
2626.1 (2139.6–3223.2)
173
3214.3 (2735.5–3776.9)
162
4037.4 (3234.4–5039.8)
19F
180
1379.9 (1144.4–1663.9)
167
1532.6 (1250.5–1878.5)
182
1742.0 (1440.1–2107.2)
164
1950.1 (1592.9–2387.4)
22F
175
2023.0 (1559.4–2624.5)
170
2178.4 (1630.9–2909.9)
175
2282.7 (1804.7–2887.3)
156
2670.6 (2062.6–3457.9)
23F
183
739.0 (559.4–976.3)
169
839.9 (639.5–1103.1)
181
2326.3 (1831.2–2955.2)
169
2212.0 (1685.3–2903.3)
33F
176
10,089.0 (7799.0–13,051.4)
166
10,909.2 (8634.0–13,783.9)
175
6788.5 (5312.9–8673.9)
166
9339.7 (7330.9–11,899.0)
† The within-group 95% CIs are obtained by exponentiating the CIs of the mean of the natural log values based on the t-distribution. n = number of participants contributing to the analysis. Note: Post-vaccination = 30 days following vaccination with PPSV23 or PCV15 (Day 30 for PPSV23 or PCV15 concomitant groups and Day 60 for PPSV23 or PCV15 sequential groups). CI: confidence interval; OPA: opsonophagocytic activity; PCV15: 15-valent pneumococcal conjugate vaccine; PPSV23: 23-valent pneumococcal polysaccharide vaccine.
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