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Protective Effects of Unsaponifiable Matter from Perilla Seed Meal on UVB-induced Damages and the Underlying Mechanisms in Human Skin Fibroblasts

1
Division of Food and Animal Sciences, Chungbuk National University, Cheongju, Chungbuk 28644, Korea
2
Department of Food Science and Biotechnology, Andong National University, Andong, Gyeongbuk 36729, Korea
3
School of Food Biotechnology & Nutrition, Kyungsung University, Busan 608-736, Korea
*
Author to whom correspondence should be addressed.
Antioxidants 2019, 8(12), 644; https://doi.org/10.3390/antiox8120644
Received: 25 November 2019 / Revised: 10 December 2019 / Accepted: 11 December 2019 / Published: 13 December 2019
Unsaponifiable matter (USM) from perilla seed meal contains numerous phytochemicals, including tocopherols, phytosterols, squalene, and policosanols, that exhibit antioxidant and health-promoting properties. In this study, the protective effects of USM on UVB-induced skin aging were investigated in Hs68 cells. UVB irradiation decreased cell viability by 26% compared to the control. However, USM blocked UVB-induced cytotoxicity. Moreover, USM treatment significantly decreased the UVB-induced production of reactive oxygen species and attenuated the UVB-induced production and mRNA expression of matrix metalloproteinases (MMPs) by inhibiting the phosphorylation of mitogen-activated protein kinases and activator protein 1 (AP-1). Furthermore, UVB exposure led to a 49.4% reduction in collagen synthesis. However, USM treatment restored collagen synthesis through upregulation of the transforming growth factor beta (TGF-β)/Smad2/3 pathways. These data indicate that USM regulates the production of MMPs and collagen by modulation of the TGF-β/Smad pathway and AP-1 activity, suggesting that USM may be a useful anti-photoaging ingredient. View Full-Text
Keywords: photoaging; skin; collagen; perilla seed meal; unsaponifiable matter photoaging; skin; collagen; perilla seed meal; unsaponifiable matter
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Lee, H.; Sung, J.; Kim, Y.; Jeong, H.S.; Lee, J. Protective Effects of Unsaponifiable Matter from Perilla Seed Meal on UVB-induced Damages and the Underlying Mechanisms in Human Skin Fibroblasts. Antioxidants 2019, 8, 644.

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