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Antioxidants, Volume 6, Issue 1

2017 March - 21 articles

Cover Story: Oxidative stress is an overabundance of free radicals compared to reducing agents and has been associated with a number of chronic diseases. While blood is the conventional biospecimen for examining oxidative stress, a noninvasive approach would be efficacious towards diagnosing pathogenetic conditions that burden the public. Saliva is a fluid found within the mouth and is a readily available biospecimen that can be utilized without rigorous training for collection. Reducing agents, such as vitamin C, and oxidized compounds, such as malondialdehyde, that reflect health can be measured in saliva, suggesting the potential of oral fluid for the analysis of oxidative stress and overall wellness. View the paper here.
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Articles (21)

  • Article
  • Open Access
41 Citations
11,613 Views
9 Pages

Krebs Cycle Intermediates Protective against Oxidative Stress by Modulating the Level of Reactive Oxygen Species in Neuronal HT22 Cells

  • Kenta Sawa,
  • Takumi Uematsu,
  • Yusuke Korenaga,
  • Ryuya Hirasawa and ,
  • Masatoshi Kikuchi,
  • Kyohei Murata,
  • Jian Zhang,
  • Xiaoqing Gai,
  • Kazuichi Sakamoto and
  • Takumi Satoh
  • + 6 authors+ 1 author

Krebs cycle intermediates (KCIs) are reported to function as energy substrates in mitochondria and to exert antioxidants effects on the brain. The present study was designed to identify which KCIs are effective neuroprotective compounds against oxida...

(This article belongs to the Special Issue Oxidative Stress and Cancer: The Nrf2 Enigma)
  • Review
  • Open Access
26 Citations
12,652 Views
14 Pages

Vitamin E Nicotinate

  • Kimbell R. Duncan and
  • Yuichiro J. Suzuki

Vitamin E refers to a family of compounds that function as lipid-soluble antioxidants capable of preventing lipid peroxidation. Naturally occurring forms of vitamin E include tocopherols and tocotrienols. Vitamin E in dietary supplements and fortifie...

  • Article
  • Open Access
15 Citations
9,409 Views
17 Pages

Effect of Leaves of Caesalpinia decapetala on Oxidative Stability of Oil-in-Water Emulsions

  • María Gabriela Gallego,
  • Monika Skowyra,
  • Michael H. Gordon,
  • Nurul Aini Mohd Azman and
  • María Pilar Almajano

Caesalpinia decapetala (Roth) Alston (Fabaceae) (CD) is used in folk medicine to prevent colds and treat bronchitis. This plant has antitumor and antioxidant activity. The antioxidant effects of an extract from Caesalpinia decapetala (Fabaceae) were...

(This article belongs to the Special Issue Feature Papers 2016)
  • Review
  • Open Access
19 Citations
10,068 Views
14 Pages

Na/K-ATPase Signaling and Salt Sensitivity: The Role of Oxidative Stress

  • Jiang Liu,
  • Yanling Yan,
  • Ying Nie and
  • Joseph I. Shapiro

Other than genetic regulation of salt sensitivity of blood pressure, many factors have been shown to regulate renal sodium handling which contributes to long-term blood pressure regulation and have been extensively reviewed. Here we present our progr...

  • Review
  • Open Access
65 Citations
12,638 Views
13 Pages

Current Insights to Regulation and Role of Telomerase in Human Diseases

  • Mert Burak Ozturk,
  • Yinghui Li and
  • Vinay Tergaonkar

28 February 2017

The telomerase ribonucleoprotein complex has a pivotal role in regulating the proliferation and senescence of normal somatic cells as well as cancer cells. This complex is comprised mainly of telomerase reverse transcriptase (TERT), telomerase RNA co...

  • Article
  • Open Access
45 Citations
11,221 Views
14 Pages

23 February 2017

Serum creatine kinase (CK) activity reflects muscle membrane disruption. Oestrogen has antioxidant and membrane stabilising properties, yet no study has compared the CK and muscle soreness (DOMS) response to unaccustomed exercise between genders when...

(This article belongs to the Special Issue Exercise Induced Muscle Damage and Oxidative Stress)
  • Review
  • Open Access
97 Citations
16,301 Views
12 Pages

Treating Cancer by Targeting Telomeres and Telomerase

  • Marko Ivancich,
  • Zachary Schrank,
  • Luke Wojdyla,
  • Brandon Leviskas and ,
  • Adijan Kuckovic,
  • Ankita Sanjali and
  • Neelu Puri
  • + 2 authors+ 0 author

19 February 2017

Telomerase is expressed in more than 85% of cancer cells. Tumor cells with metastatic potential may have a high telomerase activity, allowing cells to escape from the inhibition of cell proliferation due to shortened telomeres. Human telomerase prima...

  • Article
  • Open Access
15 Citations
8,115 Views
16 Pages

Inorganic Reactive Sulfur-Nitrogen Species: Intricate Release Mechanisms or Cacophony in Yellow, Blue and Red?

  • Marian Grman,
  • Muhammad Jawad Nasim,
  • Roman Leontiev,
  • Anton Misak and ,
  • Veronika Jakusova,
  • Karol Ondrias and
  • Claus Jacob
  • + 2 authors+ 0 author

15 February 2017

Since the heydays of Reactive Sulfur Species (RSS) research during the first decade of the Millennium, numerous sulfur species involved in cellular regulation and signalling have been discovered. Yet despite the general predominance of organic specie...

(This article belongs to the Special Issue Think Yellow: Reactive Sulfur Species in Redox Biology, Medicine and Agriculture)
  • Article
  • Open Access
35 Citations
7,948 Views
13 Pages

Selenium- and Tellurium-Based Antioxidants for Modulating Inflammation and Effects on Osteoblastic Activity

  • Xi Lu,
  • Gemma Mestres,
  • Vijay Pal Singh,
  • Pedram Effati and ,
  • Jia-Fei Poon,
  • Lars Engman and
  • Marjam Karlsson Ott
  • + 2 authors+ 0 author

14 February 2017

Increased oxidative stress plays a significant role in the etiology of bone diseases. Heightened levels of H2O2 disrupt bone homeostasis, leading to greater bone resorption than bone formation. Organochalcogen compounds could act as free radical trap...

(This article belongs to the Special Issue Selenium and Selenoproteins for Optimal Health)
  • Article
  • Open Access
41 Citations
11,335 Views
18 Pages

Proanthocyanidin Characterization and Bioactivity of Extracts from Different Parts of Uncaria tomentosa L. (Cat’s Claw)

  • Mirtha Navarro-Hoyos,
  • Rosa Lebrón-Aguilar,
  • Jesús E. Quintanilla-López,
  • Carolina Cueva and ,
  • David Hevia,
  • Silvia Quesada,
  • Gabriela Azofeifa,
  • M. Victoria Moreno-Arribas,
  • María Monagas and
  • Begoña Bartolomé
  • + 5 authors+ 0 author

4 February 2017

Apart from alkaloids, bioactive properties of Uncaria tomentosa L. have been attributed to its phenolic constituents. Although there are some reports concerning low-molecular-weight polyphenols in U. tomentosa, its polymeric phenolic composition has...

(This article belongs to the Special Issue Dietary Antioxidants and Health Promotion)
  • Article
  • Open Access
57 Citations
10,187 Views
15 Pages

In Vitro Lipophilic Antioxidant Capacity, Antidiabetic and Antibacterial Activity of Citrus Fruits Extracts from Aceh, Indonesia

  • Ernawita,
  • Ruri Agung Wahyuono,
  • Jana Hesse,
  • Uta-Christina Hipler and ,
  • Peter Elsner and
  • Volker Böhm
  • + 1 author+ 0 author

3 February 2017

This study reports in vitro lipophilic antioxidant, inhibition of α-amylase and antibacterial activities of extracts of peel and pulp of citrus samples from Aceh, Indonesia. HPLC (high-performance liquid chromatography), phytochemical, and FTIR (four...

(This article belongs to the Special Issue Feature Papers 2016)
  • Communication
  • Open Access
30 Citations
7,707 Views
11 Pages

2 February 2017

The optimum conditions for the antioxidant extraction from maqui berry were determined using a response surface methodology. A three level D-optimal design was used to investigate the effects of three independent variables namely, solvent type (metha...

(This article belongs to the Special Issue Extraction of Antioxidants: Innovative and Intensification Methods, Activity Enhancement and Degradations)
  • Article
  • Open Access
8 Citations
8,404 Views
9 Pages

Borututu (Cochlospermum angolensis) is an African tree whose bark has recently emerged as a herbal dietary supplement with claims for antioxidant activity. In order to substantiate the claimed activity of borututu supplements, we performed an activit...

(This article belongs to the Special Issue Feature Papers 2016)
  • Article
  • Open Access
24 Citations
6,758 Views
11 Pages

A Comparative Study of the Phenolic and Technological Maturities of Red Grapes Grown in Lebanon

  • Hiba N. Rajha,
  • Nada El Darra,
  • Sally El Kantar,
  • Zeina Hobaika and ,
  • Nicolas Louka and
  • Richard G. Maroun
  • + 1 author+ 0 author

Grape harvest date is determined according to the technological and phenolic maturities. These parameters were calculated for different red grape (Vitis vinifera L.) varieties (Cabernet Sauvignon, Merlot, Syrah, Cabernet Franc) over four years (2008,...

  • Review
  • Open Access
207 Citations
24,520 Views
27 Pages

Red fruits, as rich antioxidant foods, have gained over recent years capital importance for consumers and manufacturers. The industrial extraction of the phenolic molecules from this source has been taking place with the conventional solvent extracti...

(This article belongs to the Special Issue Feature Papers 2016)
  • Review
  • Open Access
37 Citations
8,390 Views
16 Pages

Exercise-Induced Oxidative Stress Responses in the Pediatric Population

  • Alexandra Avloniti,
  • Athanasios Chatzinikolaou,
  • Chariklia K. Deli,
  • Dimitris Vlachopoulos and ,
  • Luis Gracia-Marco,
  • Diamanda Leontsini,
  • Dimitrios Draganidis,
  • Athanasios Z. Jamurtas,
  • George Mastorakos and
  • Ioannis G. Fatouros
  • + 5 authors+ 0 author

Adults demonstrate an upregulation of their pro- and anti-oxidant mechanisms in response to acute exercise while systematic exercise training enhances their antioxidant capacity, thereby leading to a reduced generation of free radicals both at rest a...

(This article belongs to the Special Issue Exercise Induced Muscle Damage and Oxidative Stress)
  • Review
  • Open Access
40 Citations
15,840 Views
21 Pages

Saliva is easily obtainable for medical research and requires little effort or training for collection. Because saliva contains a variety of biological compounds, including vitamin C, malondialdehyde, amylase, and proteomes, it has been successfully...

(This article belongs to the Special Issue Feature Papers 2016)
  • Review
  • Open Access
26 Citations
11,000 Views
12 Pages

Think Yellow and Keep Green—Role of Sulfanes from Garlic in Agriculture

  • Awais Anwar,
  • Emma Gould,
  • Ryan Tinson,
  • Murree Groom and
  • Chris J. Hamilton

30 December 2016

Reactive sulfur species from garlic have long been renowned for their health benefits and antimicrobial properties. In agriculture the subject matter is now gathering momentum in the search for new bio-pesticides to addressing emerging environmental...

(This article belongs to the Special Issue Think Yellow: Reactive Sulfur Species in Redox Biology, Medicine and Agriculture)
  • Review
  • Open Access
76 Citations
52,696 Views
16 Pages

29 December 2016

Polyphenols are antioxidant molecules found in many foods including nuts, fruits, vegetables, chocolate, wine, and tea. Polyphenols have antimicrobial, anti-inflammatory, and antineoplastic properties. Recent studies suggest that tea polyphenols may...

  • Article
  • Open Access
115 Citations
18,054 Views
16 Pages

The Effects of Allicin, a Reactive Sulfur Species from Garlic, on a Selection of Mammalian Cell Lines

  • Martin C. H. Gruhlke,
  • Carole Nicco,
  • Frederic Batteux and
  • Alan J. Slusarenko

26 December 2016

Garlic (Allium sativum L.) has been used as a spice and medicinal plant since ancient times. Garlic produces the thiol-reactive defence substance, allicin, upon wounding. The effects of allicin on human lung epithelium carcinoma (A549), mouse fibrobl...

(This article belongs to the Special Issue Think Yellow: Reactive Sulfur Species in Redox Biology, Medicine and Agriculture)
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Antioxidants - ISSN 2076-3921