Next Article in Journal
Krebs Cycle Intermediates Protective against Oxidative Stress by Modulating the Level of Reactive Oxygen Species in Neuronal HT22 Cells
Previous Article in Journal
Effect of Leaves of Caesalpinia decapetala on Oxidative Stability of Oil-in-Water Emulsions
Article Menu
Issue 1 (March) cover image

Export Article

Correction published on 3 May 2018, see Antioxidants 2018, 7(5), 64.

Open AccessReview
Antioxidants 2017, 6(1), 20;

Vitamin E Nicotinate

Department of Pharmacology and Physiology, Georgetown University Medical Center, 3900 Reservoir Road NW, Washington, DC 20057, USA
Author to whom correspondence should be addressed.
Academic Editor: Adrianne Bendich
Received: 27 December 2016 / Revised: 21 February 2017 / Accepted: 7 March 2017 / Published: 13 March 2017
Full-Text   |   PDF [1185 KB, uploaded 4 May 2018]   |  


Vitamin E refers to a family of compounds that function as lipid-soluble antioxidants capable of preventing lipid peroxidation. Naturally occurring forms of vitamin E include tocopherols and tocotrienols. Vitamin E in dietary supplements and fortified foods is often an esterified form of α-tocopherol, the most common esters being acetate and succinate. The vitamin E esters are hydrolyzed and converted into free α-tocopherol prior to absorption in the intestinal tract. Because its functions are relevant to many chronic diseases, vitamin E has been extensively studied in respect to a variety of diseases as well as cosmetic applications. The forms of vitamin E most studied are natural α-tocopherol and the esters α-tocopheryl acetate and α-tocopheryl succinate. A small number of studies include or focus on another ester form, α-tocopheryl nicotinate, an ester of vitamin E and niacin. Some of these studies raise the possibility of differences in metabolism and in efficacy between vitamin E nicotinate and other forms of vitamin E. Recently, through metabolomics studies, we identified that α-tocopheryl nicotinate occurs endogenously in the heart and that its level is dramatically decreased in heart failure, indicating the possible biological importance of this vitamin E ester. Since knowledge about vitamin E nicotinate is not readily available in the literature, the purpose of this review is to summarize and evaluate published reports, specifically with respect to α-tocopheryl nicotinate with an emphasis on the differences from natural α-tocopherol or α-tocopheryl acetate. View Full-Text
Keywords: tocopherol nicotinate; tocopheryl nicotinate; vitamin E nicotinate tocopherol nicotinate; tocopheryl nicotinate; vitamin E nicotinate

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Duncan, K.R.; Suzuki, Y.J. Vitamin E Nicotinate. Antioxidants 2017, 6, 20.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Antioxidants EISSN 2076-3921 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top