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Antioxidants, Volume 13, Issue 9

September 2024 - 126 articles

Cover Story: Frontotemporal dementia (FTD) causes progressive neurodegeneration in the frontal and temporal lobes, impairing behavior, cognition, and language. With no effective treatment, new therapies are crucial. Dimethyl fumarate (DMF), an NRF2 activator, has shown neuroprotective, antioxidant, and anti-inflammatory effects in TAU-dependent FTD mice. This study tested DMF in TDP-43-related FTD mice with early cognitive impairment. The mice received oral DMF from the presymptomatic to symptomatic stages. Cognitive improvement was observed by postnatal day 60 and continued to increase at day 90. This correlated with the neuroprotection and reduced astrogliosis demonstrated in the dentate gyrus and prefrontal cortex. The results suggest DMF's potential for treating TDP-43-dependent FTD. View this paper
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Articles (126)

  • Article
  • Open Access
12 Citations
2,822 Views
25 Pages

21 September 2024

Oxidative stress emerges as a prominent factor in the onset and progression of intestinal inflammation, primarily due to its critical role in damaging cells and tissues. GABAergic signaling is important in the occurrence and development of various in...

  • Article
  • Open Access
1 Citations
2,180 Views
21 Pages

21 September 2024

Arugula is susceptible to postharvest deterioration. We tested the impact of exogenous antioxidant (i.e., ergothioneine and glutathione) dip solutions on arugula quality during storage at 4 °C or 10 °C for up to 17 days relative to a non-anti...

  • Article
  • Open Access
3 Citations
1,463 Views
19 Pages

20 September 2024

The identification of obese subjects at higher risk for cardiovascular disease (CVD) is required. We aimed to characterize determinants of endothelial dysfunction, the initial step to CVD, in small omental arteries of visceral fat from obese subjects...

  • Review
  • Open Access
22 Citations
4,738 Views
25 Pages

20 September 2024

Alzheimer’s (AD) and Parkinson’s Disease (PD) are life-altering diseases that are characterised by progressive memory loss and motor dysfunction. The prevalence of AD and PD is predicted to continuously increase. Symptoms of AD and PD are...

  • Article
  • Open Access
1,604 Views
16 Pages

20 September 2024

The most prevalent chronic liver disease, known as metabolic dysfunction-associated steatotic liver disease (MASLD), is characterized by an excessive accumulation of lipids and oxidative damage. Clinopodium gracile, a natural herbal medicine widely u...

  • Article
  • Open Access
1 Citations
3,620 Views
16 Pages

20 September 2024

Alcohol-associated liver disease (ALD) is a major cause of chronic liver disease, with few effective treatments besides alcohol abstinence. Angelicae Gigantis Radix (AG), Glycyrrhizae Radix et Rhizoma (GR), Paeoniae Radix (PR), and Zizyphi Fructus (Z...

  • Article
  • Open Access
21 Citations
5,428 Views
15 Pages

Evaluation of the Protective Role of Vitamin E against ROS-Driven Lipid Oxidation in Model Cell Membranes

  • Dilara Kilicarslan You,
  • Ahmed Fuwad,
  • Ki Hyok Lee,
  • Hyung Kyo Kim,
  • Lifeng Kang,
  • Sun Min Kim and
  • Tae-Joon Jeon

20 September 2024

Reactive oxygen species (ROS) are chemically reactive oxygen-containing compounds generated by various factors in the body. Antioxidants mitigate the damaging effects of ROS by playing a critical role in regulating redox balance and signaling. In thi...

  • Article
  • Open Access
4 Citations
2,819 Views
15 Pages

19 September 2024

Studying the effects of genetic and environmental factors on plant biochemical components helps in selecting the best varieties for the food industry and breeding programs. This study analyzed the nutritional qualities, secondary metabolites, and ant...

  • Article
  • Open Access
17 Citations
2,843 Views
20 Pages

Polyphenolic Screening and the Antioxidant Activity of Grape Pomace Extracts of Romanian White and Red Grape Varieties

  • Cristiana Radulescu,
  • Radu Lucian Olteanu,
  • Claudia Lavinia Buruleanu,
  • Mihaela Nechifor (Tudorache),
  • Ioana Daniela Dulama,
  • Raluca Maria Stirbescu,
  • Ioan Alin Bucurica,
  • Sorina Geanina Stanescu and
  • Andreea Laura Banica

19 September 2024

Due to its valuable organic compounds, grape pomace represents a valuable resource in the creation of value-added food products. In this study, we investigated grape pomace hydroalcoholic extracts obtained by ultrasonication from two white and two re...

  • Article
  • Open Access
4 Citations
1,766 Views
17 Pages

Polyphenolic Profile and Antioxidant Activity of Whole Grape Juices from Vitis labrusca and Brazilian Hybrid Grapes in Two Training Systems

  • Francisco José Domingues Neto,
  • Adilson Pimentel Junior,
  • Cristine Vanz Borges,
  • João Domingos Rodrigues,
  • Ricardo Figueira,
  • Mara Fernandes Moura,
  • Igor Otavio Minatel,
  • Aline Nunes,
  • Giuseppina Pace Pereira Lima and
  • Marco Antonio Tecchio

19 September 2024

The phenolic profile and antioxidant activity of whole grape juices from Vitis labrusca and Brazilian hybrids in two training systems were analyzed. Genotypes of V. labrusca (‘Bordô’ and ‘Isabel’) and Brazilian hybrids (...

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Antioxidants - ISSN 2076-3921