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Antioxidants, Volume 13, Issue 12

December 2024 - 160 articles

Cover Story: Neuroinflammation is a common feature in age-related neurodegenerative diseases like Alzheimer's and Parkinson's. This review highlights the role of mitochondrial oxidative stress in driving this inflammation. Mitochondria-generated reactive oxygen species (ROS) are key players in inflammatory signaling pathways, including inflammasomes and the cGAS-STING pathway. This response can ultimately trigger immunogenic cell death, such as pyroptosis, necroptosis, and metal-ion-induced cell death. Understanding these mechanisms can help us identify new therapeutic targets to modulate the inflammatory response and potentially slow disease progression. View this paper
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Articles (160)

  • Correction
  • Open Access
828 Views
2 Pages

20 December 2024

In the originally published article [...]

  • Article
  • Open Access
4 Citations
2,167 Views
15 Pages

Bioactive Content and Antioxidant Properties of Spray-Dried Microencapsulates of Peumus boldus M. Leaf Extracts

  • Valentina Polanco,
  • Débora Cerdá-Bernad,
  • Issis Quispe-Fuentes,
  • Claudia Bernal and
  • Jéssica López

20 December 2024

Boldo (Peumus boldus M.), an plant endemic to central and southern Chile, has been recognized as a medicinal herb, especially its leaves that are rich in bioactive compounds with beneficial properties, such as antioxidant, anti-inflammatory, sedative...

  • Review
  • Open Access
9 Citations
11,631 Views
14 Pages

Vitamins, Coenzyme Q10, and Antioxidant Strategies to Improve Oocyte Quality in Women with Gynecological Cancers: A Comprehensive Review

  • Isaic Alexandru,
  • Daciana Nistor,
  • Alexandru Catalin Motofelea,
  • Bianca-Astrid Cadar (Andone),
  • Andreea Crintea,
  • Carmen Tatu,
  • Gheorghe Nicusor Pop and
  • Andrei Nicolae Csep

19 December 2024

Background: Gynecological cancers, including ovarian, cervical, and endometrial cancers, significantly affect both survival and reproductive health in women. Cancer treatments such as chemotherapy and radiotherapy can impair ovarian function, reducin...

  • Article
  • Open Access
3 Citations
1,951 Views
20 Pages

19 December 2024

Low-selenium status was associated with impaired renal function, which improved after selenium and coenzyme Q10 supplementation in an RCT. Here, we evaluated serum glutathione peroxidase-3 (GPx3) and its relation to serum selenium, selenoprotein P (S...

  • Systematic Review
  • Open Access
2 Citations
2,850 Views
20 Pages

Relevant Serum Endoplasmic Reticulum Stress Biomarkers in Type 2 Diabetes and Its Complications: A Systematic Review and Meta-Analysis

  • José Rafael Villafan-Bernal,
  • Francisco Barajas-Olmos,
  • Iris Paola Guzmán-Guzmán,
  • Angélica Martínez-Hernández,
  • Cecilia Contreras-Cubas,
  • Humberto García-Ortiz,
  • Monserrat I. Morales-Rivera,
  • Raigam Jafet Martínez-Portilla and
  • Lorena Orozco

19 December 2024

Endoplasmic reticulum stress (ERS) is activated in all cells by stressors such as hyperglycemia. However, it remains unclear which specific serum biomarkers of ERS are consistently altered in type 2 diabetes (T2D). We aimed to identify serum ERS biom...

  • Article
  • Open Access
1 Citations
1,277 Views
21 Pages

Glutathione Involvement in Potato Response to French Marigold Volatile Organic Compounds

  • Jelena Savić,
  • Đura Nakarada,
  • Sofija Stupar,
  • Ljiljana Tubić,
  • Milica Milutinović,
  • Miloš Mojović and
  • Nina Devrnja

19 December 2024

To elucidate the involvement of glutathione in the mitigation of induced oxidative changes and the sequestration of perceived volatiles in cells, we exposed potato plants to French marigold essential oil. The formation of short-lived radicals, the de...

  • Review
  • Open Access
5 Citations
4,219 Views
38 Pages

Facts, Dogmas, and Unknowns About Mitochondrial Reactive Oxygen Species in Cancer

  • Milagros Junco,
  • Clara Ventura,
  • Florencia Ximena Santiago Valtierra and
  • Eduardo Nestor Maldonado

19 December 2024

Cancer metabolism is sustained both by enhanced aerobic glycolysis, characteristic of the Warburg phenotype, and oxidative metabolism. Cell survival and proliferation depends on a dynamic equilibrium between mitochondrial function and glycolysis, whi...

  • Article
  • Open Access
8 Citations
6,460 Views
21 Pages

19 December 2024

Citrus peel essential oil (CPEO) is favored by people for its aromatic scent, while also possessing numerous bioactive compounds that are advantageous to human health. This study evaluated the antioxidant, anti-inflammatory, and anticancer activities...

  • Review
  • Open Access
6,663 Views
14 Pages

19 December 2024

Numerous studies have documented that high-intensity or prolonged exercise is associated with increased oxidative stress and modification of antioxidant status. Polyphenol-rich dietary supplements seem to be the compounds that can upregulate the endo...

  • Review
  • Open Access
2,471 Views
24 Pages

Overview of Clinical Relevance of Antibodies Against Oxidized Low-Density Lipoprotein (oLAb) Within Three Decades by ELISA Technology

  • Willibald Wonisch,
  • Franz Tatzber,
  • Meinrad Lindschinger,
  • Andreas Falk,
  • Ulrike Resch,
  • Sabrina Mörkl,
  • Neven Zarkovic and
  • Gerhard Cvirn

19 December 2024

One of the most prominent actions of oxidative stress is the attack of free radicals on poylyunsaturated fatty acids (PUFAs), initiating a chain reaction to modify these PUFAs and generate oxidized modifications on all biomolecules. In the last quart...

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Antioxidants - ISSN 2076-3921