Next Article in Journal
Roles of Oxidative Stress in Synaptic Dysfunction and Neuronal Cell Death in Alzheimer’s Disease
Previous Article in Journal
On Males, Antioxidants and Infertility (MOXI): Certitudes, Uncertainties and Trends
Previous Article in Special Issue
Human NCF190H Variant Promotes IL-23/IL-17—Dependent Mannan-Induced Psoriasis and Psoriatic Arthritis
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Antioxidants
Volume 12
Issue 8
10.3390/antiox12081627
antioxidants-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Biomarkers of Oxidative Stress in Systemic Lupus Erythematosus Patients with Active Nephritis

by
Lu Liu
1,
Karina de Leeuw
1,
Suzanne Arends
1,
Berber Doornbos-van der Meer
1,
Marian L. C. Bulthuis
2,
Harry van Goor
2 and
Johanna Westra
1,* on behalf of the Dutch LN Studies
1
Department of Rheumatology and Clinical Immunology, University Medical Centre Groningen, 9713 GZ Groningen, The Netherlands
2
Department of Pathology and Medical Biology, University Medical Centre Groningen, 9713 GZ Groningen, The Netherlands
*
Author to whom correspondence should be addressed.
Antioxidants 2023, 12(8), 1627; https://doi.org/10.3390/antiox12081627
Submission received: 20 July 2023 / Revised: 11 August 2023 / Accepted: 14 August 2023 / Published: 17 August 2023
(This article belongs to the Special Issue Oxidative Stress in Rheumatic Diseases)
Browse Figures
Versions Notes

Abstract

Oxidative stress plays an important role in systemic lupus erythematosus (SLE) and especially in lupus nephritis (LN). The aim of this study was to compare redox-related biomarkers between patients with active LN, quiescent SLE (Q-SLE) and healthy controls (HC) and to explore their association with clinical characteristics such as disease activity in patients. We investigated levels of plasma free thiols (R-SH, sulfhydryl groups), levels of soluble receptor for advanced glycation end products (sRAGE) and levels of malondialdehyde (MDA) in SLE patients with active LN (n = 23), patients with quiescent SLE (n = 47) and HC (n = 23). Data of LN patients who previously participated in Dutch lupus nephritis studies and longitudinal samples up to 36 months were analyzed. Thiol levels were lower in active LN at baseline and Q-SLE patients compared to HC. In generalized estimating equation (GEE) modelling, free thiol levels were negatively correlated with the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) over time (p < 0.001). sRAGE and MDA were positively correlated with the SLEDAI over time (p = 0.035 and p = 0.016, respectively). These results indicate that oxidative stress levels in LN patients are increased compared to HC and associated with SLE disease activity. Therefore, interventional therapy to restore redox homeostasis may be useful as an adjunctive therapy in the treatment of oxidative damage in SLE.
Keywords: reactive oxygen species (ROS); free thiols; malondialdehyde (MDA); soluble receptor for advanced glycation end products (sRAGE) reactive oxygen species (ROS); free thiols; malondialdehyde (MDA); soluble receptor for advanced glycation end products (sRAGE)
Graphical Abstract

Share and Cite

MDPI and ACS Style

Liu, L.; de Leeuw, K.; Arends, S.; Doornbos-van der Meer, B.; Bulthuis, M.L.C.; van Goor, H.; Westra, J., on behalf of the Dutch LN Studies. Biomarkers of Oxidative Stress in Systemic Lupus Erythematosus Patients with Active Nephritis. Antioxidants 2023, 12, 1627. https://doi.org/10.3390/antiox12081627

AMA Style

Liu L, de Leeuw K, Arends S, Doornbos-van der Meer B, Bulthuis MLC, van Goor H, Westra J on behalf of the Dutch LN Studies. Biomarkers of Oxidative Stress in Systemic Lupus Erythematosus Patients with Active Nephritis. Antioxidants. 2023; 12(8):1627. https://doi.org/10.3390/antiox12081627

Chicago/Turabian Style

Liu, Lu, Karina de Leeuw, Suzanne Arends, Berber Doornbos-van der Meer, Marian L. C. Bulthuis, Harry van Goor, and Johanna Westra on behalf of the Dutch LN Studies. 2023. "Biomarkers of Oxidative Stress in Systemic Lupus Erythematosus Patients with Active Nephritis" Antioxidants 12, no. 8: 1627. https://doi.org/10.3390/antiox12081627

APA Style

Liu, L., de Leeuw, K., Arends, S., Doornbos-van der Meer, B., Bulthuis, M. L. C., van Goor, H., & Westra, J., on behalf of the Dutch LN Studies. (2023). Biomarkers of Oxidative Stress in Systemic Lupus Erythematosus Patients with Active Nephritis. Antioxidants, 12(8), 1627. https://doi.org/10.3390/antiox12081627

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop