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Antioxidants, Volume 12, Issue 5

May 2023 - 158 articles

Cover Story: Age-related diseases represent the largest threat to public health. Aging is a degenerative, systemic, and progressive process, coupled with progressive loss of function and eventually leading to high mortality rates. Molecular hydrogen (H2) has recently been reported to function as an anti-oxidant and anti-inflammatory agent for the treatment of several oxidative stress and aging-related diseases, including Alzheimer’s, Parkinson’s, and cancer. Additionally, H2 promotes healthy aging, increases the number of good germs in the intestine that produce more intestinal hydrogen, and reduces oxidative stress through its anti-oxidant and anti-inflammatory activities. This review manuscript will contribute to our knowledge of the role of H2 in redox mechanisms for promoting health and longevity. View this paper
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Articles (158)

  • Article
  • Open Access
17 Citations
2,915 Views
21 Pages

Enhancing the Stability and Bioaccessibility of Tree Peony Seed Oil Using Layer-by-Layer Self-Assembling Bilayer Emulsions

  • Wen-Sen He,
  • Qingzhi Wang,
  • Zhishuo Li,
  • Jie Li,
  • Liying Zhao,
  • Junjie Li,
  • Chen Tan and
  • Fayong Gong

Tree peony seed oil (TPSO) is an important plant source of n-3 polyunsaturated fatty acid (α-linolenic acid, ALA > 40%) that is receiving increasing attention for its excellent antioxidant and other activities. However, it has poor stability...

  • Article
  • Open Access
7 Citations
3,185 Views
17 Pages

The Rhodanese PspE Converts Thiosulfate to Cellular Sulfane Sulfur in Escherichia coli

  • Qiaoli Yu,
  • Mingxue Ran,
  • Yuping Xin,
  • Huaiwei Liu,
  • Honglei Liu,
  • Yongzhen Xia and
  • Luying Xun

Hydrogen sulfide (H2S) and its oxidation product zero-valent sulfur (S0) play important roles in animals, plants, and bacteria. Inside cells, S0 exists in various forms, including polysulfide and persulfide, which are collectively referred to as sulf...

  • Review
  • Open Access
51 Citations
12,591 Views
29 Pages

Oxidative Stress, Reductive Stress and Antioxidants in Vascular Pathogenesis and Aging

  • Mitko Mladenov,
  • Lubomir Lubomirov,
  • Olaf Grisk,
  • Dimiter Avtanski,
  • Vadim Mitrokhin,
  • Iliyana Sazdova,
  • Milena Keremidarska-Markova,
  • Yana Danailova,
  • Georgi Nikolaev and
  • Rossitza Konakchieva
  • + 1 author

This review is focused on the mechanisms that regulate health, disease and aging redox status, the signal pathways that counteract oxidative and reductive stress, the role of food components and additives with antioxidant properties (curcumin, polyph...

  • Feature Paper
  • Article
  • Open Access
9 Citations
3,413 Views
15 Pages

Glutathione (GSH) and phenols are well-known antioxidants, and previous research has suggested that their combination can enhance antioxidant activity. In this study, we used Quantum Chemistry and computational kinetics to investigate how this synerg...

  • Article
  • Open Access
2 Citations
26,011 Views
20 Pages

Effect of N-Acetylcysteine on Sleep: Impacts of Sex and Time of Day

  • Priyanka N. Bushana,
  • Michelle A. Schmidt,
  • Kevin M. Chang,
  • Trisha Vuong,
  • Barbara A. Sorg and
  • Jonathan P. Wisor

Non-rapid eye movement sleep (NREMS) is accompanied by a decrease in cerebral metabolism, which reduces the consumption of glucose as a fuel source and decreases the overall accumulation of oxidative stress in neural and peripheral tissues. Enabling...

  • Article
  • Open Access
11 Citations
3,924 Views
23 Pages

Microbiota-Liver-Bile Salts Axis, a Novel Mechanism Involved in the Contrasting Effects of Sodium Selenite and Selenium-Nanoparticle Supplementation on Adipose Tissue Development in Adolescent Rats

  • María Luisa Ojeda,
  • Fátima Nogales,
  • José A. Carrasco López,
  • María del Carmen Gallego-López,
  • Olimpia Carreras,
  • Ana Alcudia and
  • Eloísa Pajuelo

Adolescence is a period during which body composition changes deeply. Selenium (Se) is an excellent antioxidant trace element related to cell growth and endocrine function. In adolescent rats, low Se supplementation affects adipocyte development diff...

  • Article
  • Open Access
24 Citations
4,217 Views
16 Pages

Pingwei San Ameliorates Spleen Deficiency-Induced Diarrhea through Intestinal Barrier Protection and Gut Microbiota Modulation

  • Yimeng Fan,
  • Qingyu Zhao,
  • Yuanyuan Wei,
  • Huiru Wang,
  • Yu Ga,
  • Yannan Zhang and
  • Zhihui Hao

Pingwei San (PWS) has been used for more than a thousand years as a traditional Chinese medicine prescription for treating spleen-deficiency diarrhea (SDD). Nevertheless, the exact mechanism by which it exerts its antidiarrheal effects remains unclea...

  • Article
  • Open Access
6 Citations
3,577 Views
20 Pages

“Golden” Tomato Consumption Ameliorates Metabolic Syndrome: A Focus on the Redox Balance in the High-Fat-Diet-Fed Rat

  • Giuditta Gambino,
  • Giuseppe Giglia,
  • Mario Allegra,
  • Valentina Di Liberto,
  • Francesco Paolo Zummo,
  • Francesca Rappa,
  • Ignazio Restivo,
  • Filippo Vetrano,
  • Filippo Saiano and
  • Eristanna Palazzolo
  • + 4 authors

Tomato fruits defined as “golden” refer to a food product harvested at an incomplete ripening stage with respect to red tomatoes at full maturation. The aim of this study is to explore the putative influence of “golden tomato”...

  • Article
  • Open Access
19 Citations
5,398 Views
21 Pages

Fruit Peel Powder as Natural Antioxidant and Reinforcing Bio-Filler in Natural Rubber Latex Gloves: Cases of Mangosteen, Pomelo and Durian

  • Arkarapol Thumwong,
  • Jitsuna Darachai,
  • Nuatawan Thamrongsiripak,
  • Shinji Tokonami,
  • Tetsuo Ishikawa and
  • Kiadtisak Saenboonruang

As the world is facing rapid increases in agricultural wastes that greatly affect global health, the environment, and economies, this work aims to alleviate such issues by introducing simple uses of waste fruit peel powder (FPP) derived from mangoste...

  • Article
  • Open Access
3 Citations
2,737 Views
14 Pages

Quality-by-Design R&D of a Novel Nanozyme-Based Sensor for Saliva Antioxidant Capacity Evaluation

  • Riccardo Goldoni,
  • Douglas Vieira Thomaz,
  • Lucanos Strambini,
  • Margherita Tumedei,
  • Paola Dongiovanni,
  • Gaetano Isola and
  • Gianluca Tartaglia

Oxidative stress is one of the main causes of cell damage, leading to the onset of several diseases, and antioxidants represent a barrier against the production of reactive species. Saliva is receiving increasing interest as a promising biofluid to s...

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Antioxidants - ISSN 2076-3921