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Antioxidants
Volume 11
Issue 8
10.3390/antiox11081542
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Article

Antioxidant Capacities and Enzymatic Inhibitory Effects of Different Solvent Fractions and Major Flavones from Celery Seeds Produced in Different Geographic Areas in China

by
Chao Zhang
1,
Jing Yu
2,
Qiang Tu
2,
Fu Yan
2,
Zhao Hu
3,
Youming Zhang
2,* and
Chun Song
2,*
1
Institute of Marine and Technology, Shandong University, 72 Binhai Road, Jimo, Qingdao 266237, China
2
State Key Laboratory of Microbial Technology, Shandong University, 72 Binhai Road, Jimo, Qingdao 266237, China
3
Department of Nephrology, Qilu Hospital Dezhou Hospital, Shandong University, Dezhou 253000, China
*
Authors to whom correspondence should be addressed.
Antioxidants 2022, 11(8), 1542; https://doi.org/10.3390/antiox11081542
Submission received: 11 July 2022 / Revised: 4 August 2022 / Accepted: 6 August 2022 / Published: 9 August 2022
(This article belongs to the Special Issue Antioxidant Capacity of Bioactive Plant Compounds for Therapeutic Purpose)
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Abstract

To extend the application of celery (Apium graveolens L.) seeds, the antioxidant and enzymatic inhibitory activities of different fractions and their main flavones were investigated. The n-butanol fractions possessed the highest total phenolic content (TPC) and total flavonoid content (TFC) values. The n-butanol fractions from Northeast China samples exhibited the strongest free radical scavenging (DPPH IC50 = 20.27 μg/mL, ABTS IC50 = 15.11 μg/mL) and ferric reducing antioxidant power (FRAP 547.93 mg trolox (TE)/g) capacity, while those collected from Hubei China showed the optimal cupric reducing antioxidant capacity (CUPRAC) values (465.78 mg TE/g). In addition, the dichloromethane fractions from Jiangsu samples displayed a maximum Fe2+ chelating capacity (20.81 mg ethylene diamine tetraacetic acid (EDTA)/g). Enzyme level experiments indicated polyphenolic compounds might be the main hypoglycemic active components. Subsequently, the enzyme inhibitory activity of nine main flavones was evaluated. Chrysoeriol-7-O-glucoside showed better α-glucosidase inhibitory activity than others. However, apigenin showed the best inhibitory effect on α-amylases, while the presence of glycosides would reduce its inhibitory effect. This study is the first scientific report on the enzymatic inhibitory activity, molecular docking, and antioxidant capacity of celery seed constituents, providing a basis for treating or preventing oxidative stress-related diseases and hyperglycemia.
Keywords: Celery (Apium graveolens L.) seed; different solvent fractions; main flavone glycosides; antioxidant capacities; α-amylase inhibitory activities; α-glucosidase inhibitory activities; molecular docking Celery (Apium graveolens L.) seed; different solvent fractions; main flavone glycosides; antioxidant capacities; α-amylase inhibitory activities; α-glucosidase inhibitory activities; molecular docking

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MDPI and ACS Style

Zhang, C.; Yu, J.; Tu, Q.; Yan, F.; Hu, Z.; Zhang, Y.; Song, C. Antioxidant Capacities and Enzymatic Inhibitory Effects of Different Solvent Fractions and Major Flavones from Celery Seeds Produced in Different Geographic Areas in China. Antioxidants 2022, 11, 1542. https://doi.org/10.3390/antiox11081542

AMA Style

Zhang C, Yu J, Tu Q, Yan F, Hu Z, Zhang Y, Song C. Antioxidant Capacities and Enzymatic Inhibitory Effects of Different Solvent Fractions and Major Flavones from Celery Seeds Produced in Different Geographic Areas in China. Antioxidants. 2022; 11(8):1542. https://doi.org/10.3390/antiox11081542

Chicago/Turabian Style

Zhang, Chao, Jing Yu, Qiang Tu, Fu Yan, Zhao Hu, Youming Zhang, and Chun Song. 2022. "Antioxidant Capacities and Enzymatic Inhibitory Effects of Different Solvent Fractions and Major Flavones from Celery Seeds Produced in Different Geographic Areas in China" Antioxidants 11, no. 8: 1542. https://doi.org/10.3390/antiox11081542

APA Style

Zhang, C., Yu, J., Tu, Q., Yan, F., Hu, Z., Zhang, Y., & Song, C. (2022). Antioxidant Capacities and Enzymatic Inhibitory Effects of Different Solvent Fractions and Major Flavones from Celery Seeds Produced in Different Geographic Areas in China. Antioxidants, 11(8), 1542. https://doi.org/10.3390/antiox11081542

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