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Antioxidants, Volume 10, Issue 6

June 2021 - 172 articles

Cover Story: The amphipolar iron(III) corrole 1-Fe has emerged as a promising therapeutic agent for oxidative-stress-related diseases. It decomposes reactive oxygen and nitrogen species in a highly catalytic and effective manner, acting as a synthetic SOD/catalase/thioredoxin enzyme, decomposing superoxide anion radical, hydrogen peroxide and peroxynitrite, respectively. 1-Fe displays a robust efficacy in murine models of diabetes, neuropathy, and atherosclerosis, and further research has described its potential as a therapeutic agent for Parkinson’s and Alzheimer’s diseases. In this study, we disclose the efficacy of 1-Fe in a G93R-mutated SOD1 ALS zebrafish model. The displayed results disclose a substantial improvement in locomotor activity for ALS fish treated by 1-Fe relative to their non-treated counterparts. View this paper.
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Articles (172)

  • Article
  • Open Access
30 Citations
6,897 Views
13 Pages

Green Tea Extract Enhances the Oxidative Stability of DHA-Rich Oil

  • Caroline Waingeh Nain,
  • Gwennaëlle Berdal,
  • Phan Thi Phuong Thao,
  • Eric Mignolet,
  • Marine Buchet,
  • Melissa Page and
  • Yvan Larondelle

Docosahexaenoic acid (DHA) is one of the most important omega-3 polyunsaturated fatty acids, with proven health-promoting properties. However, oils with a very high content in DHA (DHAO) are extremely susceptible to oxidation, which affects shelf sta...

  • Article
  • Open Access
22 Citations
5,082 Views
13 Pages

Nonaqueous Polyethylene Glycol as a Safer Alternative to Ethanolic Propolis Extracts with Comparable Antioxidant and Antimicrobial Activity

  • Jelena Šuran,
  • Ivica Cepanec,
  • Tomislav Mašek,
  • Kristina Starčević,
  • Ivana Tlak Gajger,
  • Mihaela Vranješ,
  • Božo Radić,
  • Saša Radić,
  • Ivan Kosalec and
  • Josipa Vlainić

We compared the chemical composition, antioxidant and antimicrobial activity of two propolis extracts: one obtained with nonaqueous polyethylene glycol, PEG 400 (PgEP), and the other obtained with ethanol (EEP). We analyzed the total phenolic content...

  • Article
  • Open Access
24 Citations
5,763 Views
23 Pages

Cytoprotective Effects of Fish Protein Hydrolysates against H2O2-Induced Oxidative Stress and Mycotoxins in Caco-2/TC7 Cells

  • Mercedes Taroncher,
  • Yelko Rodríguez-Carrasco,
  • Tone Aspevik,
  • Katerina Kousoulaki,
  • Francisco J. Barba and
  • María-José Ruiz

Many studies report the potent antioxidant capacity for fish protein hydrolysates, including radical scavenging activity and inhibition ability on lipid peroxidation (LPO). In this study, the in vitro cytotoxicity of protein hydrolysates from differe...

  • Review
  • Open Access
25 Citations
5,584 Views
18 Pages

Peroxiredoxins—The Underrated Actors during Virus-Induced Oxidative Stress

  • Inna L. Karpenko,
  • Vladimir T. Valuev-Elliston,
  • Olga N. Ivanova,
  • Olga A. Smirnova and
  • Alexander V. Ivanov

Enhanced production of reactive oxygen species (ROS) triggered by various stimuli, including viral infections, has attributed much attention in the past years. It has been shown that different viruses that cause acute or chronic diseases induce oxida...

  • Article
  • Open Access
15 Citations
5,067 Views
11 Pages

More than a year ago, the first case of infection by a new coronavirus was identified, which subsequently produced a pandemic causing human deaths throughout the world. Much research has been published on this virus, and discoveries indicate that oxi...

  • Article
  • Open Access
19 Citations
3,151 Views
14 Pages

Newborns of Mothers with Venous Disease during Pregnancy Show Increased Levels of Lipid Peroxidation and Markers of Oxidative Stress and Hypoxia in the Umbilical Cord

  • Miguel A. Ortega,
  • Lara Sánchez-Trujillo,
  • Coral Bravo,
  • Oscar Fraile-Martinez,
  • Cielo García-Montero,
  • Miguel A. Saez,
  • Miguel A. Alvarez-Mon,
  • Felipe Sainz,
  • Melchor Alvarez-Mon and
  • Julia Bujan
  • + 2 authors

Chronic venous disease (CVD) encompasses a set of disorders of the venous system that have a high prevalence in Western societies and are associated with significant sociohealth costs. Pregnancy is a period in which different hormonal and haemodynami...

  • Feature Paper
  • Article
  • Open Access
14 Citations
4,824 Views
23 Pages

New Insights on NETosis Induced by Entamoeba histolytica: Dependence on ROS from Amoebas and Extracellular MPO Activity

  • César Díaz-Godínez,
  • Joshue Fabián Jorge-Rosas,
  • Mario Néquiz,
  • Santiago Martínez-Calvillo,
  • Juan P. Laclette,
  • Carlos Rosales and
  • Julio C. Carrero

NETosis is a neutrophil process involving sequential steps from pathogen detection to the release of DNA harboring antimicrobial proteins, including the central generation of NADPH oxidase dependent or independent ROS. Previously, we reported that NE...

  • Article
  • Open Access
85 Citations
6,850 Views
18 Pages

This study investigates the protective effect of baicalein on carbon tetrachloride (CCl4)-induced acute liver injury and the underlying molecular mechanisms. Mice were orally administrated baicalein at 25 and 100 mg/kg/day for 7 consecutive days or f...

  • Article
  • Open Access
16 Citations
5,787 Views
15 Pages

This study investigated the effect of ethanol-extracted green lettuce leaf (GLE) on sleep behavior in physical stress-induced invertebrate and vertebrate models. In Drosophila melanogaster, the group that experienced vibration stress showed decreased...

  • Review
  • Open Access
32 Citations
8,455 Views
33 Pages

Use of Antioxidants for the Neuro-Therapeutic Management of COVID-19

  • Noemí Cárdenas-Rodríguez,
  • Cindy Bandala,
  • América Vanoye-Carlo,
  • Iván Ignacio-Mejía,
  • Saúl Gómez-Manzo,
  • Estefani Yaquelin Hernández-Cruz,
  • José Pedraza-Chaverri,
  • Liliana Carmona-Aparicio and
  • Beatriz Hernández-Ochoa

Coronavirus Disease 2019 (COVID-19), caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), is an emergent infectious disease that has caused millions of deaths throughout the world. COVID-19 infection’s main symptoms are fever, coug...

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Antioxidants - ISSN 2076-3921Creative Common CC BY license