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Brain Sciences, Volume 8, Issue 3

March 2018 - 11 articles

Cover Story: This picture shows a strong serotonin immunoreactivity in the thoracic rat spinal cord white matter following a two-month dietary regimen high in Vitamin E. The increase in serotonin levels induced by Vitamin E was observed in control/sham rats and it was sustained even following spinal cord injury (SCI). These data support the hypothesis that elevated levels of serotonin mediate at least in part the improved functional recovery shown in rats receiving a diet rich in Vitamin E. The study proposes the use of Vitamin E to improve recovery from SCI and associated complications by therapeutically targeting serotonin levels. View the paper here.
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Articles (11)

  • Article
  • Open Access
12 Citations
5,432 Views
11 Pages

Hypoxia-ischemia (H-I) at the time of birth may cause neonatal death or lead to persistent brain damage. The search for an effective treatment of asphyxiated infants has not resulted in an effective therapy, and hypothermia remains the only available...

  • Communication
  • Open Access
24 Citations
7,774 Views
9 Pages

The Internet has played a major role in the distribution of New Psychoactive Substances (NPS), and crypto markets are increasingly used for the anonymous sale of drugs, including NPS. This study explores the availability of individual NPS and vendors...

  • Review
  • Open Access
119 Citations
48,382 Views
18 Pages

Hallucinogen Persisting Perception Disorder: Etiology, Clinical Features, and Therapeutic Perspectives

  • Giovanni Martinotti,
  • Rita Santacroce,
  • Mauro Pettorruso,
  • Chiara Montemitro,
  • Maria Chiara Spano,
  • Marco Lorusso,
  • Massimo Di Giannantonio and
  • Arturo G. Lerner

Hallucinogen Persisting Perception Disorder (HPPD) is a rare, and therefore, poorly understood condition linked to hallucinogenic drugs consumption. The prevalence of this disorder is low; the condition is more often diagnosed in individuals with a h...

  • Article
  • Open Access
28 Citations
10,168 Views
18 Pages

l-Carnitine Modulates Epileptic Seizures in Pentylenetetrazole-Kindled Rats via Suppression of Apoptosis and Autophagy and Upregulation of Hsp70

  • Abdelaziz M. Hussein,
  • Mohamed Adel,
  • Mohamed El-Mesery,
  • Khaled M. Abbas,
  • Amr N. Ali and
  • Osama A. Abulseoud

l-Carnitine is a unique nutritional supplement for athletes that has been recently studied as a potential treatment for certain neuropsychiatric disorders. However, its efficacy in seizure control has not been investigated. Sprague Dawley rats were r...

  • Review
  • Open Access
14 Citations
7,530 Views
11 Pages

Many novel psychoactive substances (NPS) have entered the recreational drug scene in recent years, yet the problems they cause are similar to those found with established drugs. This article will debate the psychobiological effects of these newer and...

  • Case Report
  • Open Access
27 Citations
10,280 Views
10 Pages

Epilepsy Surgery for Skull-Base Temporal Lobe Encephaloceles: Should We Spare the Hippocampus from Resection?

  • Firas Bannout,
  • Sheri Harder,
  • Michael Lee,
  • Alexander Zouros,
  • Ravi Raghavan,
  • Travis Fogel,
  • Kenneth De Los Reyes and
  • Travis Losey

The neurosurgical treatment of skull base temporal encephalocele for patients with epilepsy is variable. We describe two adult cases of temporal lobe epilepsy (TLE) with spheno-temporal encephalocele, currently seizure-free for more than two years af...

  • Article
  • Open Access
3 Citations
6,440 Views
10 Pages

Brain Response to Non-Painful Mechanical Stimulus to Lumbar Spine

  • Zaid M. Mansour,
  • Laura E. Martin,
  • Rebecca J. Lepping,
  • Saddam F. Kanaan,
  • William M. Brooks,
  • Hung-Wen Yeh and
  • Neena K. Sharma

Pressure application to the lumbar spine is an important assessment and treatment method of low back pain. However, few studies have characterized brain activation patterns in response to mechanical pressure. The objective of this study was to map br...

  • Article
  • Open Access
1 Citations
4,634 Views
18 Pages

Abstraction and Idealization in Biomedicine: The Nonautonomous Theory of Acute Cell Injury

  • Donald J. DeGracia,
  • Doaa Taha,
  • Fika Tri Anggraini,
  • Shreya Sutariya,
  • Gabriel Rababeh and
  • Zhi-Feng Huang

27 February 2018

Neuroprotection seeks to halt cell death after brain ischemia and has been shown to be possible in laboratory studies. However, neuroprotection has not been successfully translated into clinical practice, despite voluminous research and controlled cl...

  • Review
  • Open Access
95 Citations
17,996 Views
19 Pages

27 February 2018

Background—Cannabis is the most popular illicit drug in the Western world. Repeated cannabis use has been associated with short and long-term range of adverse effects. Recently, new types of designer-drugs containing synthetic cannabinoids have been...

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Brain Sci. - ISSN 2076-3425