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Article

A Solvent-Free, One-Step, One-Pot Gewald Reaction for Alkyl-aryl Ketones via Mechanochemistry

University of Cincinnati, Cincinnati, OH 45221-0172, USA
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Appl. Sci. 2014, 4(2), 171-179; https://doi.org/10.3390/app4020171
Received: 16 November 2013 / Revised: 25 February 2014 / Accepted: 18 March 2014 / Published: 8 April 2014
(This article belongs to the Special Issue Greener and Sustainable Chemistry)
Herein, we report on the solvent-free synthesis of 2-aminothiophenes via the Gewald reaction. Utilizing high speed ball milling conditions, we discovered the Gewald reaction can be catalytic in base, and conducted under aerobic conditions. Using thermal heat in tandem with the mixer/mill significantly increases the rate of reaction. View Full-Text
Keywords: Gewald; solvent-free; ball milling; green chemistry; multicomponent reaction Gewald; solvent-free; ball milling; green chemistry; multicomponent reaction
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MDPI and ACS Style

Shearouse, W.C.; Shumba, M.Z.; Mack, J. A Solvent-Free, One-Step, One-Pot Gewald Reaction for Alkyl-aryl Ketones via Mechanochemistry. Appl. Sci. 2014, 4, 171-179. https://doi.org/10.3390/app4020171

AMA Style

Shearouse WC, Shumba MZ, Mack J. A Solvent-Free, One-Step, One-Pot Gewald Reaction for Alkyl-aryl Ketones via Mechanochemistry. Applied Sciences. 2014; 4(2):171-179. https://doi.org/10.3390/app4020171

Chicago/Turabian Style

Shearouse, William C., Maxwell Z. Shumba, and James Mack. 2014. "A Solvent-Free, One-Step, One-Pot Gewald Reaction for Alkyl-aryl Ketones via Mechanochemistry" Applied Sciences 4, no. 2: 171-179. https://doi.org/10.3390/app4020171

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