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Medical Sciences, Volume 6, Issue 1

March 2018 - 25 articles

Cover Story: Over half of all melanoma tumors express a mutant BRAF protein. We hypothesized that polyamines are essential for tumor survival in mutant BRAF melanomas. Compared to normal cells, tumor cells have elevated levels of polyamines resulting from increased polyamine biosynthesis and polyamine transport system (PTS) activity. Here we show that PTS activity is significantly upregulated in mutant BRAFV600E melanoma cells compared to BRAFWT melanoma cells, resulting in greater sensitivity to a novel PTS-targeted, cytotoxic, polyamine-containing compound. Utilizing the PTS for delivery, this cytotoxic compound attacks melanoma cells via one of its key modes of survival. View the paper here.
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Articles (25)

  • Article
  • Open Access
2 Citations
4,297 Views
10 Pages

Diagnostic Utility of High Sensitivity Troponins for Echocardiographic Markers of Structural Heart Disease

  • Tom Kai Ming Wang,
  • Clementina Dugo,
  • Gillian Whalley,
  • Yvonne Wynne,
  • Heather Semple,
  • Kevin Smith,
  • Peter Cleave,
  • Jonathan Christiansen,
  • Andrew To and
  • Nezar Amir
  • + 3 authors

15 February 2018

The conventional use of high-sensitivity troponins (hs-troponins) is for diagnosing myocardial infarction however they also have a role in chronic disease management. This pilot study assessed the relationship of hs-troponins with echocardiographic m...

  • Review
  • Open Access
38 Citations
11,355 Views
15 Pages

Skeletal Muscle Pathophysiology: The Emerging Role of Spermine Oxidase and Spermidine

  • Manuela Cervelli,
  • Alessia Leonetti,
  • Guglielmo Duranti,
  • Stefania Sabatini,
  • Roberta Ceci and
  • Paolo Mariottini

14 February 2018

Skeletal muscle comprises approximately 40% of the total body mass. Preserving muscle health and function is essential for the entire body in order to counteract chronic diseases such as type II diabetes, cardiovascular diseases, and cancer. Prolonge...

  • Review
  • Open Access
8 Citations
6,852 Views
8 Pages

8 February 2018

This review summarizes the available literature on the intersection of adolescent cannabis use and sleep disturbances, along with interventions for adolescent cannabis users who suffer sleep impairments. Adolescents are susceptible to various sleep d...

  • Review
  • Open Access
60 Citations
12,003 Views
17 Pages

8 February 2018

The fluorinated ornithine analog α-difluoromethylornithine (DFMO, eflornithine, ornidyl) is an irreversible suicide inhibitor of ornithine decarboxylase (ODC), the first and rate-limiting enzyme of polyamine biosynthesis. The ubiquitous and essential...

  • Article
  • Open Access
1 Citations
3,078 Views
6 Pages

6 February 2018

Central nervous system (CNS) abnormalities are often isolated but can accompany various genetic syndromes. In this study, we evaluated conventional karyotype results and associated findings of fetuses that were diagnosed with CNS abnormalities. Cases...

  • Editorial
  • Open Access
10,435 Views
3 Pages

2 February 2018

At the European Gynecological Oncology Congress (ESGO) 2017, held in Vienna, a symposium on immunotherapy took place: A New Strategy for the Treatment of Cervical Cancer, sponsored by Advaxis, Inc.

  • Feature Paper
  • Article
  • Open Access
14 Citations
6,113 Views
18 Pages

The Role of Cadaverine Synthesis on Pneumococcal Capsule and Protein Expression

  • Mary F. Nakamya,
  • Moses B. Ayoola,
  • Seongbin Park,
  • Leslie A. Shack,
  • Edwin Swiatlo and
  • Bindu Nanduri

19 January 2018

Invasive infections caused by Streptococcus pneumoniae, a commensal in the nasopharynx, pose significant risk to human health. Limited serotype coverage by the available polysaccharide-based conjugate vaccines coupled with increasing incidence of ant...

  • Viewpoint
  • Open Access
82 Citations
7,176 Views
6 Pages

18 January 2018

Antibiotic combinations are preferred for the treatment of periodontal diseases, with the aim of hitting the bacterial flora, according to its characteristics—aerobic, anaerobic, gram-negative, and gram-positive—with certain antibiotics that act on c...

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Med. Sci. - ISSN 2076-3271