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Medical Sciences, Volume 6, Issue 1

March 2018 - 25 articles

Cover Story: Over half of all melanoma tumors express a mutant BRAF protein. We hypothesized that polyamines are essential for tumor survival in mutant BRAF melanomas. Compared to normal cells, tumor cells have elevated levels of polyamines resulting from increased polyamine biosynthesis and polyamine transport system (PTS) activity. Here we show that PTS activity is significantly upregulated in mutant BRAFV600E melanoma cells compared to BRAFWT melanoma cells, resulting in greater sensitivity to a novel PTS-targeted, cytotoxic, polyamine-containing compound. Utilizing the PTS for delivery, this cytotoxic compound attacks melanoma cells via one of its key modes of survival. View the paper here.

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Articles (25)

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Article

30 Citations

4,835 Views

14 Pages

Acute Traumatic Endotheliopathy in Isolated Severe Brain Injury and Its Impact on Clinical Outcome

Venencia Albert,
Arulselvi Subramanian,
Deepak Agrawal,
Hara Prasad Pati,
Siddhartha Datta Gupta and
Asok Kumar Mukhopadhyay

Med. Sci.2018, 6(1), 5;https://doi.org/10.3390/medsci6010005

16 January 2018

Study design: Prospective observational cohort. Objective: To investigate the difference in plasma levels of syndecan-1 (due to glycocalyx degradation) and soluble thrombomodulin (due to endothelial damage) in isolated severe traumatic brain injury (...

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Review

16 Citations

9,263 Views

12 Pages

Role of Polyamines in Asthma Pathophysiology

Vaibhav Jain

Med. Sci.2018, 6(1), 4;https://doi.org/10.3390/medsci6010004

6 January 2018

Asthma is a complex disease of airways, where the interactions of immune and structural cells result in disease outcomes with airway remodeling and airway hyper-responsiveness. Polyamines, which are small-sized, natural super-cations, interact with n...

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Article

21 Citations

6,323 Views

12 Pages

A Novel Polyamine-Targeted Therapy for BRAF Mutant Melanoma Tumors

Molly C. Peters,
Allyson Minton,
Otto Phanstiel IV and
Susan K. Gilmour

Med. Sci.2018, 6(1), 3;https://doi.org/10.3390/medsci6010003

5 January 2018

Mutant serine/threonine protein kinase B-Raf (BRAF) protein is expressed in over half of all melanoma tumors. Although BRAF inhibitors (BRAFi) elicit rapid anti-tumor responses in the majority of patients with mutant BRAF melanoma, the tumors inevita...

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Article

1 Citations

4,222 Views

9 Pages

The ODC 3′-Untranslated Region and 5′-Untranslated Region Contain cis-Regulatory Elements: Implications for Carcinogenesis

Shannon L. Nowotarski and
Lisa M. Shantz

Med. Sci.2018, 6(1), 2;https://doi.org/10.3390/medsci6010002

22 December 2017

It has been hypothesized that both the 3′-untranslated region (3′UTR) and the 5′-untranslated region (5′UTR) of the ornithine decarboxylase (ODC) mRNA influence the expression of the ODC protein. Here, we use luciferase expression constructs to exami...

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Review

529 Citations

31,514 Views

28 Pages

Carbapenem Resistance: A Review

Francis S. Codjoe and
Eric S. Donkor

Med. Sci.2018, 6(1), 1;https://doi.org/10.3390/medsci6010001

21 December 2017

Carbapenem resistance is a major and an on-going public health problem globally. It occurs mainly among Gram-negative pathogens such as Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter baumannii, and may be intrinsic or mediated by tra...

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