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Medical Sciences, Volume 6, Issue 1

March 2018 - 25 articles

Cover Story: Over half of all melanoma tumors express a mutant BRAF protein. We hypothesized that polyamines are essential for tumor survival in mutant BRAF melanomas. Compared to normal cells, tumor cells have elevated levels of polyamines resulting from increased polyamine biosynthesis and polyamine transport system (PTS) activity. Here we show that PTS activity is significantly upregulated in mutant BRAFV600E melanoma cells compared to BRAFWT melanoma cells, resulting in greater sensitivity to a novel PTS-targeted, cytotoxic, polyamine-containing compound. Utilizing the PTS for delivery, this cytotoxic compound attacks melanoma cells via one of its key modes of survival. View the paper here.
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Articles (25)

  • Review
  • Open Access
17 Citations
5,500 Views
13 Pages

13 March 2018

Polyamine levels are elevated in breast tumors compared to those of adjacent normal tissues. The female sex hormone, estrogen is implicated in the origin and progression of breast cancer. Estrogens stimulate and antiestrogens suppress the expression...

  • Article
  • Open Access
13 Citations
5,101 Views
9 Pages

The Association between Body Mass Index and Health-Related Quality of Life in Treatment-Seeking Arab Adults with Obesity

  • Leila Itani,
  • Simona Calugi,
  • Riccardo Dalle Grave,
  • Dima Kreidieh,
  • Germine El Kassas,
  • Dana El Masri,
  • Hana Tannir,
  • Aya Harfoush and
  • Marwan El Ghoch

13 March 2018

Few studies have thus far been carried out on Health-Related Quality of Life (HRQoL) and obesity in Arab-speaking countries, an issue that we therefore set out to investigate in this study. HRQoL was assessed by the validated Arabic version of the OR...

  • Feature Paper
  • Review
  • Open Access
114 Citations
10,825 Views
19 Pages

Role of Polyamines in Immune Cell Functions

  • Rebecca S. Hesterberg,
  • John L. Cleveland and
  • Pearlie K. Epling-Burnette

The immune system is remarkably responsive to a myriad of invading microorganisms and provides continuous surveillance against tissue damage and developing tumor cells. To achieve these diverse functions, multiple soluble and cellular components must...

  • Article
  • Open Access
8 Citations
4,708 Views
12 Pages

Malignancy of cancer has been linked to distinct subsets of stem-like cells, the so-called cancer stem cells (CSCs), which persist during treatment and seem to lead to drug-resistant recurrence. Metastatic spread of cancer cells is one of the hallmar...

  • Article
  • Open Access
2 Citations
3,431 Views
9 Pages

Electrodermal Activity during Blood Pooling for Arterial Blood Gases Analysis in Sedated Adult Intensive Care Unit Patients

  • Theodoros Aslanidis,
  • Vasilios Grosomanidis,
  • Konstantinos Karakoulas and
  • Athanasios Chatzisotiriou

Electrodermal activity (EDA) is considered a measure of autonomous nervous system activity. This study performed an exploratory analysis of the EDA changes during blood pooling for arterial blood gas analysis in sedated adult critical care patients a...

  • Article
  • Open Access
19 Citations
5,145 Views
13 Pages

Synovial sarcoma is a high-grade soft tissue sarcoma that inflicts mostly children and young adults with high mortality rate; however, the risk factors that impact the outcomes remain incompletely understood. We have identified the synovial sarcoma c...

  • Review
  • Open Access
79 Citations
14,946 Views
10 Pages

Artemisinin and Its Synthetic Derivatives as a Possible Therapy for Cancer

  • Enrique Konstat-Korzenny,
  • Jorge Alberto Ascencio-Aragón,
  • Sebastian Niezen-Lugo and
  • Rosalino Vázquez-López

27 February 2018

To assess the possibility of using the antimalarial drug artemisinin and its synthetic derivatives as antineoplastic drugs. A Pubmed and Google Scholar (1983–2018) search was performed using the terms artemisinin, cancer, artesunate and Artemisia ann...

  • Article
  • Open Access
2 Citations
13,098 Views
7 Pages

23 February 2018

As part of a university-based quality improvement project, we aimed to evaluate child psychiatrists’ knowledge, skills, attitudes, and practices regarding assessment and treatment of pediatric sleep problems. We developed a nine-question survey of kn...

  • Review
  • Open Access
34 Citations
12,292 Views
16 Pages

15 February 2018

Traumatic brain injury (TBI) is commonplace among pediatric patients and has a complex, but intimate relationship with psychiatric disease and disordered sleep. Understanding the factors that influence the risk for the development of TBI in pediatric...

  • Feature Paper
  • Review
  • Open Access
46 Citations
18,103 Views
10 Pages

15 February 2018

Narcolepsy and psychiatric disorders have a significant but unrecognized relationship, which is an area of evolving interest, but unfortunately, the association is poorly understood. It is not uncommon for the two to occur co-morbidly. However, narco...

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Med. Sci. - ISSN 2076-3271Creative Common CC BY license