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Microorganisms
Volume 9
Issue 4
10.3390/microorganisms9040735
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Article

Peroral Clove Essential Oil Treatment Ameliorates Acute Campylobacteriosis—Results from a Preclinical Murine Intervention Study

by
Stefan Bereswill
1,†,
Soraya Mousavi
1,†,
Dennis Weschka
1,
Agnes Buczkowski
1,2,
Sebastian Schmidt
1,2 and
Markus M. Heimesaat
1,*
1
Gastrointestinal Microbiology Research Group, Institute of Microbiology, Infectious Diseases and Immunology, Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 12203 Berlin, Germany
2
Hofmann & Sommer GmbH und Co. KG, Büro Berlin, 12489 Berlin, Germany
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Microorganisms 2021, 9(4), 735; https://doi.org/10.3390/microorganisms9040735
Submission received: 19 March 2021 / Revised: 29 March 2021 / Accepted: 31 March 2021 / Published: 31 March 2021
(This article belongs to the Special Issue Foodborne Bacteria–Host Interactions)
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Abstract

Campylobacter (C.) jejuni infections pose progressively emerging threats to human health worldwide. Given the rise in antibiotic resistance, antibiotics-independent options are required to fight campylobacteriosis. Since the health-beneficial effects of clove have been known for long, we here analyzed the antimicrobial and immune-modulatory effects of clove essential oil (EO) during acute experimental campylobacteriosis. Therefore, microbiota-depleted interleukin-10 deficient (IL-10−/−) mice were perorally infected with C. jejuni and treated with clove EO via drinking water starting on day 2 post-infection. On day 6 post-infection, lower small- and large-intestinal pathogen loads could be assessed in clove EO as compared to placebo treated mice. Although placebo mice suffered from severe campylobacteriosis as indicated by wasting and bloody diarrhea, clove EO treatment resulted in a better clinical outcome and in less severe colonic histopathological and apoptotic cell responses in C. jejuni infected mice. Furthermore, lower colonic numbers of macrophages, monocytes, and T lymphocytes were detected in mice from the verum versus the placebo cohort that were accompanied by lower intestinal, extra-intestinal, and even systemic proinflammatory cytokine concentrations. In conclusion, our preclinical intervention study provides first evidence that the natural compound clove EO constitutes a promising antibiotics-independent treatment option of acute campylobacteriosis in humans.
Keywords: clove essential oil; enteropathogenic infection; Campylobacter jejuni; immune-modulatory effects; microbiota-depleted IL-10−/− mice; acute campylobacteriosis model; host-pathogen interaction; preclinical intervention study; natural antibiotics-independent compounds; eugenol clove essential oil; enteropathogenic infection; Campylobacter jejuni; immune-modulatory effects; microbiota-depleted IL-10−/− mice; acute campylobacteriosis model; host-pathogen interaction; preclinical intervention study; natural antibiotics-independent compounds; eugenol

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MDPI and ACS Style

Bereswill, S.; Mousavi, S.; Weschka, D.; Buczkowski, A.; Schmidt, S.; Heimesaat, M.M. Peroral Clove Essential Oil Treatment Ameliorates Acute Campylobacteriosis—Results from a Preclinical Murine Intervention Study. Microorganisms 2021, 9, 735. https://doi.org/10.3390/microorganisms9040735

AMA Style

Bereswill S, Mousavi S, Weschka D, Buczkowski A, Schmidt S, Heimesaat MM. Peroral Clove Essential Oil Treatment Ameliorates Acute Campylobacteriosis—Results from a Preclinical Murine Intervention Study. Microorganisms. 2021; 9(4):735. https://doi.org/10.3390/microorganisms9040735

Chicago/Turabian Style

Bereswill, Stefan, Soraya Mousavi, Dennis Weschka, Agnes Buczkowski, Sebastian Schmidt, and Markus M. Heimesaat. 2021. "Peroral Clove Essential Oil Treatment Ameliorates Acute Campylobacteriosis—Results from a Preclinical Murine Intervention Study" Microorganisms 9, no. 4: 735. https://doi.org/10.3390/microorganisms9040735

APA Style

Bereswill, S., Mousavi, S., Weschka, D., Buczkowski, A., Schmidt, S., & Heimesaat, M. M. (2021). Peroral Clove Essential Oil Treatment Ameliorates Acute Campylobacteriosis—Results from a Preclinical Murine Intervention Study. Microorganisms, 9(4), 735. https://doi.org/10.3390/microorganisms9040735

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