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Microorganisms
Volume 9
Issue 3
10.3390/microorganisms9030537
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Communication

High Prevalence of Carbapenemase-Producing Acinetobacter baumannii in Wound Infections, Ghana, 2017/2018

by
Mathieu Monnheimer
1,
Paul Cooper
2,
Harold K. Amegbletor
2,
Theresia Pellio
2,
Uwe Groß
1,
Yvonne Pfeifer
3,† and
Marco H. Schulze
1,4,*,†
1
Institute for Medical Microbiology and Göttingen International Health Network, University Medical Center Göttingen, Kreuzbergring 57, 37075 Göttingen, Germany
2
St. Martin de Porres Hospital, Post Office Box 06, Eikwe via Axim, Ghana
3
Nosocomial Pathogens and Antibiotic Resistance, Robert Koch Institute, Burgstrasse 37, 38855 Wernigerode, Germany
4
Institute of Infection Control and Infectious Diseases, University Medical Centre Göttingen, Robert-Koch-Strasse 40, 37075 Göttingen, Germany
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Microorganisms 2021, 9(3), 537; https://doi.org/10.3390/microorganisms9030537
Submission received: 3 February 2021 / Revised: 24 February 2021 / Accepted: 27 February 2021 / Published: 5 March 2021
(This article belongs to the Special Issue Molecular Epidemiology of Antimicrobial Resistance)
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Abstract

Three years after a prospective study on wound infections in a rural hospital in Ghana revealed no emergence of carbapenem-resistant bacteria we initiated a new study to assess the prevalence of multidrug-resistant pathogens. Three hundred and one samples of patients with wound infections were analysed for the presence of resistant bacteria in the period August 2017 till March 2018. Carbapenem-resistant Acinetobacter (A.) baumannii were further characterized by resistance gene sequencing, PCR-based bacterial strain typing, pulsed-field gel electrophoresis (PFGE) and multilocus sequence typing (MLST “Oxford scheme”). A. baumanni was detected in wound infections of 45 patients (15%); 22 isolates were carbapenem-resistant. Carbapenemases NDM-1 and/or OXA-23 were detected in all isolates; two isolates harboured additionally OXA-420. PFGE and MLST analyses confirmed the presence of one A. baumannii strain in 17 patients that was assigned to the worldwide spread sequence type ST231 and carried NDM-1 and OXA-23. Furthermore, two new A. baumannii STs (ST2145 and ST2146) were detected in two and three patients, respectively. Within three years the prevalence of carbapenem-resistant A. baumannii increased dramatically in the hospital. The early detection of multidrug-resistant bacteria and prevention of their further spread are only possible if continuous surveillance and molecular typing will be implemented.
Keywords: Acinetobacter baumannii; carbapenem resistance; OXA-23; OXA-420; NDM-1; wound infections; Ghana; rural Acinetobacter baumannii; carbapenem resistance; OXA-23; OXA-420; NDM-1; wound infections; Ghana; rural

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MDPI and ACS Style

Monnheimer, M.; Cooper, P.; Amegbletor, H.K.; Pellio, T.; Groß, U.; Pfeifer, Y.; Schulze, M.H. High Prevalence of Carbapenemase-Producing Acinetobacter baumannii in Wound Infections, Ghana, 2017/2018. Microorganisms 2021, 9, 537. https://doi.org/10.3390/microorganisms9030537

AMA Style

Monnheimer M, Cooper P, Amegbletor HK, Pellio T, Groß U, Pfeifer Y, Schulze MH. High Prevalence of Carbapenemase-Producing Acinetobacter baumannii in Wound Infections, Ghana, 2017/2018. Microorganisms. 2021; 9(3):537. https://doi.org/10.3390/microorganisms9030537

Chicago/Turabian Style

Monnheimer, Mathieu, Paul Cooper, Harold K. Amegbletor, Theresia Pellio, Uwe Groß, Yvonne Pfeifer, and Marco H. Schulze. 2021. "High Prevalence of Carbapenemase-Producing Acinetobacter baumannii in Wound Infections, Ghana, 2017/2018" Microorganisms 9, no. 3: 537. https://doi.org/10.3390/microorganisms9030537

APA Style

Monnheimer, M., Cooper, P., Amegbletor, H. K., Pellio, T., Groß, U., Pfeifer, Y., & Schulze, M. H. (2021). High Prevalence of Carbapenemase-Producing Acinetobacter baumannii in Wound Infections, Ghana, 2017/2018. Microorganisms, 9(3), 537. https://doi.org/10.3390/microorganisms9030537

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