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Microorganisms
Volume 9
Issue 2
10.3390/microorganisms9020446
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Article

Competitive Exclusion of Intra-Genus Salmonella in Neonatal Broilers

by
Megan Pineda
1,
Michael Kogut
2,
Kenneth Genovese
2,
Yuhua Z. Farnell
1,
Dan Zhao
1,
Xi Wang
1,
Allison Milby
1 and
Morgan Farnell
1,*
1
Department of Poultry Science, Texas A&M AgriLife Research, College Station, TX 77843, USA
2
Southern Plains Agricultural Research Center, Agricultural Research Service, United States Department of Agriculture, College Station, TX 77843, USA
*
Author to whom correspondence should be addressed.
Microorganisms 2021, 9(2), 446; https://doi.org/10.3390/microorganisms9020446
Submission received: 2 February 2021 / Revised: 18 February 2021 / Accepted: 19 February 2021 / Published: 21 February 2021
(This article belongs to the Section Molecular Microbiology and Immunology)
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Abstract

Salmonellosis is a zoonotic infection caused by Salmonella enterica serotypes contracted from contaminated products. We hypothesized that competitive exclusion between Salmonella serotypes in neonatal broilers would reduce colonization and affect the host immune response. Day of hatch broilers were randomly allocated to one of six treatment groups: (1) control, which received saline, (2) Salmonella Kentucky (SK) only on day 1 (D1), (3) Salmonella Typhimurium (ST) or Salmonella Enteritidis (SE) only on D1, (4) SK on D1 then ST or SE on day 2 (D2), (5) ST or SE on D1 then SK on D2, and (6) SK and ST or SE concurrently on D1. Salmonella gut colonization and incidence were measured from cecal contents. Livers and spleens were combined and macerated to determine systemic translocation. Relative mRNA levels of interleukin-1β (IL-1β), IL-6, IL-10, IL-18, and gamma interferon (IFN-γ) were measured in cecal tonsils and liver to investigate local and systemic immune responses. When a serotype was administered first, it was able to significantly reduce colonization of the following serotype. Significant changes were found in mRNA expression of cytokines. These results suggest competitive exclusion by Salmonella enterica serotypes affect local and systemic immune responses.
Keywords: broiler; Salmonella Kentucky; Salmonella Typhimurium; Salmonella Enteritidis; colonization resistance; poultry; immune response; cytokine broiler; Salmonella Kentucky; Salmonella Typhimurium; Salmonella Enteritidis; colonization resistance; poultry; immune response; cytokine

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MDPI and ACS Style

Pineda, M.; Kogut, M.; Genovese, K.; Farnell, Y.Z.; Zhao, D.; Wang, X.; Milby, A.; Farnell, M. Competitive Exclusion of Intra-Genus Salmonella in Neonatal Broilers. Microorganisms 2021, 9, 446. https://doi.org/10.3390/microorganisms9020446

AMA Style

Pineda M, Kogut M, Genovese K, Farnell YZ, Zhao D, Wang X, Milby A, Farnell M. Competitive Exclusion of Intra-Genus Salmonella in Neonatal Broilers. Microorganisms. 2021; 9(2):446. https://doi.org/10.3390/microorganisms9020446

Chicago/Turabian Style

Pineda, Megan, Michael Kogut, Kenneth Genovese, Yuhua Z. Farnell, Dan Zhao, Xi Wang, Allison Milby, and Morgan Farnell. 2021. "Competitive Exclusion of Intra-Genus Salmonella in Neonatal Broilers" Microorganisms 9, no. 2: 446. https://doi.org/10.3390/microorganisms9020446

APA Style

Pineda, M., Kogut, M., Genovese, K., Farnell, Y. Z., Zhao, D., Wang, X., Milby, A., & Farnell, M. (2021). Competitive Exclusion of Intra-Genus Salmonella in Neonatal Broilers. Microorganisms, 9(2), 446. https://doi.org/10.3390/microorganisms9020446

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