Abstract
The global emergence of coronavirus disease 2019 (COVID-19) was caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The clinical manifestations of COVID-19 in patients range from asymptomatic disease to severe multiorgan dysfunction and even death. Moreover, the growing population of clinically immunodeficient patients and the use of single clinical antifungal agents have gradually increased the incidence of Aspergillus fumigatus infections, the complex clinical manifestations of which are yet to be fully clarified. The mortality rate among COVID-19 patients coinfected with A. fumigatus has risen significantly. Therefore, a comprehensive understanding of the diagnosis and treatment of A. fumigatus infections, SARS-CoV-2 infections, and their coinfections is crucial. In this review, we first provide a comprehensive description of the life cycle of A. fumigatus, together with an in-depth analysis of its characteristics, diagnosis, and treatment strategies for associated diseases. Then, the basic structure of SARS-CoV-2, the evolution of variant strains, and key aspects of its prevention and control are discussed. Finally, the symptoms, diagnosis, and treatment of COVID-19 coinfection with A. fumigatus are summarized. In this paper, we provide methodological references and data to support the clinical prevention and treatment of A. fumigatus and SARS-CoV-2 infections.