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Pathogens, Volume 11, Issue 2

2022 February - 169 articles

Cover Story: Shigella is a highly infectious human pathogen responsible for 269 million reported cases and 200,000 deaths per year. Its virulence relies on the activity of the ATPase Spa47 to power the injection of effector proteins into human host cells through the needle-like type three secretion system injectisome. Here, we explore the effects of recently identified posttranslational tyrosine phosphorylation in Spa47 using a myriad of in vitro and in vivo protein characterization and pathogen phenotyping techniques. The results uncover a striking correlation between Spa47 tyrosine phosphorylation state, Spa47 ATPase activity, T3SS function, and Shigella virulence, suggesting that posttranslational tyrosine phosphorylation represents a potent means for native regulation of Shigella virulence and a much-needed target for non-antibiotic therapeutics. View this paper
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Articles (169)

  • Article
  • Open Access
5 Citations
4,367 Views
6 Pages

21 February 2022

Yersinia enterocolitica and Y. pseudotuberculosis are important causes of enteric illness worldwide. Rapid response to suspected foodborne outbreaks is hampered by the widespread use of cold enrichment methods that require incubation periods of 10&nd...

(This article belongs to the Special Issue Yersinia enterocolitica and Yersinia pseudotuberculosis—Zoonotic Pathogens of Relevance to Public Health)
  • Article
  • Open Access
8 Citations
3,211 Views
10 Pages

21 February 2022

Highly specific and sensitive diagnostic methods are vital for the effective control and treatment of toxoplasmosis. Routine diagnosis is primarily serological because T. gondii infections stimulate persistently high IgG antibody responses. The sensi...

(This article belongs to the Section Immunological Responses and Immune Defense Mechanisms)
  • Article
  • Open Access
12 Citations
4,269 Views
12 Pages

20 February 2022

Radiologists should be aware of the findings of alveolar echinococcosis (AE) due to the diagnostic and management value of imaging. We are attempting to define the most common diagnostic imaging findings of liver AE, along with the prevalence and dis...

(This article belongs to the Special Issue Alveolar Echinococcosis: Joining Hands to Tackle a Lethal Parasitosis)
  • Review
  • Open Access
14 Citations
7,103 Views
38 Pages

SARS-CoV-2 and Coronavirus Disease Mitigation: Treatment Options, Vaccinations and Variants

  • Almu’atasim Khamees,
  • Jamal Bani-Issa,
  • Mazhar Salim Al Zoubi,
  • Taqwa Qasem,
  • Manal Issam AbuAlArjah,
  • Sura Ahmad Alawadin,
  • Khayry Al-Shami,
  • Farah E. Hussein,
  • Emad Hussein and
  • Christopher T. Cornelison
  • + 3 authors

20 February 2022

COVID-19 is caused by a novel coronavirus (2019-nCoV), which was declared as a pandemic after it emerged in China 2019. A vast international effort has been conducted to prevent and treat COVID-19 due to its high transmissibility and severe morbidity...

  • Review
  • Open Access
65 Citations
10,371 Views
22 Pages

Adaptive Cellular Immunity against African Swine Fever Virus Infections

  • Alexander Schäfer,
  • Giulia Franzoni,
  • Christopher L. Netherton,
  • Luise Hartmann,
  • Sandra Blome and
  • Ulrike Blohm

20 February 2022

African swine fever virus (ASFV) remains a threat to global pig populations. Infections with ASFV lead to a hemorrhagic disease with up to 100% lethality in Eurasian domestic and wild pigs. Although myeloid cells are the main target cells for ASFV, T...

(This article belongs to the Section Viral Pathogens)
  • Review
  • Open Access
288 Citations
18,466 Views
21 Pages

Major Biological Control Strategies for Plant Pathogens

  • Manisha Arora Pandit,
  • Jitendra Kumar,
  • Saloni Gulati,
  • Neeru Bhandari,
  • Poonam Mehta,
  • Roma Katyal,
  • Charu Dogra Rawat,
  • Vachaspati Mishra and
  • Jasleen Kaur

19 February 2022

Food security has become a major concern worldwide in recent years due to ever increasing population. Providing food for the growing billions without disturbing environmental balance is incessantly required in the current scenario. In view of this, s...

(This article belongs to the Topic Fungal Diversity)
  • Article
  • Open Access
4 Citations
2,808 Views
11 Pages

More Insights about the Efficacy of Copper Ion Treatment on Mycobacterium avium subsp. paratuberculosis (MAP): A Clue for the Observed Tolerance

  • Carlos Tejeda,
  • Pamela Steuer,
  • Marcela Villegas,
  • Angelica Reyes-Jara,
  • Esperanza C. Iranzo,
  • Reydoret Umaña and
  • Miguel Salgado

19 February 2022

Background: Scientific evidence is scarce for the antimicrobial effect of copper on bacteria characterized as more resistant. Using Mycobacterium avium subsp. paratuberculosis (MAP), a highly resistant microorganism, as a pathogen model, copper ion t...

(This article belongs to the Special Issue Feature Papers of Vaccines and Therapeutic Developments)
  • Review
  • Open Access
100 Citations
27,753 Views
25 Pages

19 February 2022

The handling of highly pathogenic viruses, whether for diagnostic or research purposes, often requires an inactivation step. This article reviews available inactivation techniques published in peer-reviewed journals and their benefits and limitations...

(This article belongs to the Special Issue Highly Pathogenic Viruses: Challenges for Diagnostics Development and Drug Discovery)
  • Systematic Review
  • Open Access
495 Citations
28,832 Views
14 Pages

19 February 2022

Emerging evidence has shown that COVID-19 survivors could suffer from persistent symptoms. However, it remains unclear whether these symptoms persist over the longer term. This study aimed to systematically synthesise evidence on post-COVID symptoms...

(This article belongs to the Special Issue Emerging and/or Zoonotic Viral Infections)
  • Hypothesis
  • Open Access
10 Citations
3,656 Views
9 Pages

19 February 2022

Background: Obesity is a risk factor for the development of influenza by leading to a chronic inflammatory state and T-cell dysfunction. Based upon preclinical research, metformin has influenza activity by restoring T-cell function and improving the...

(This article belongs to the Special Issue Fighting Flu—Recent Advances in Influenza Research)
  • Article
  • Open Access
12 Citations
4,097 Views
10 Pages

Metabolic Alteration of Trypanosoma cruzi during Differentiation of Epimastigote to Trypomastigote Forms

  • Salvatore G. De-Simone,
  • Saulo C. Bourguignon,
  • Priscila S. Gonçalves,
  • Guilherme C. Lechuga and
  • David W. Provance

19 February 2022

Intracellular parasites such as Trypanosoma cruzi need to acquire valuable carbon sources from the host cell to replicate. Here, we investigated the energetic metabolism of T. cruzi during metacyclogenesis through the determination of enzymatic activ...

(This article belongs to the Section Parasitic Pathogens)
  • Article
  • Open Access
4 Citations
3,743 Views
11 Pages

Plant- and Bacteria-Derived Compounds with Anti-Philasterides dicentrarchi Activity

  • Rosa Ana Sueiro,
  • José Manuel Leiro,
  • Verónica Blanco-Abad,
  • Jos Raaijmakers,
  • Irene de Bruijn,
  • Ron P. H. Dirks and
  • Jesús Lamas

18 February 2022

Philasterides dicentrarchi is a scuticociliate that causes high mortalities in farmed fish. Although vaccination is an effective method to prevent scuticociliatosis caused by the homologous serotype, a universal vaccine has not been developed yet. Ma...

(This article belongs to the Section Parasitic Pathogens)
  • Article
  • Open Access
12 Citations
3,594 Views
20 Pages

Tumor Cell Plasticity in Equine Papillomavirus-Positive Versus-Negative Squamous Cell Carcinoma of the Head and Neck

  • Carina Strohmayer,
  • Andrea Klang,
  • Stefan Kummer,
  • Ingrid Walter,
  • Christoph Jindra,
  • Christiane Weissenbacher-Lang,
  • Torben Redmer,
  • Sibylle Kneissl and
  • Sabine Brandt

18 February 2022

Squamous cell carcinoma of the head and neck (HNSCC) is a common malignant tumor in humans and animals. In humans, papillomavirus (PV)-induced HNSCCs have a better prognosis than papillomavirus-unrelated HNSCCs. The ability of tumor cells to switch f...

(This article belongs to the Special Issue Animal Papillomavirus: Virus Identification, Diagnosis and Co-infections)
  • Feature Paper
  • Article
  • Open Access
8 Citations
4,522 Views
10 Pages

Rabies Virus Variants Detected from Cougar (Puma concolor) in Mexico 2000–2021

  • Fabiola Garcés-Ayala,
  • Álvaro Aguilar-Setién,
  • Cenia Almazán-Marín,
  • Claudia Cuautle-Zavala,
  • Susana Chávez-López,
  • David Martínez-Solís,
  • Mauricio Gómez-Sierra,
  • Albert Sandoval-Borja,
  • Beatriz Escamilla-Ríos and
  • Nidia Aréchiga-Ceballos
  • + 1 author

18 February 2022

In 2019, the World Health Organization (WHO) and the Pan-American Health Organization (PAHO) recognized Mexico as a country free of human rabies transmitted by dogs. Nevertheless, the sylvatic cycle remains as a public health concern in the country....

(This article belongs to the Special Issue Emerging and Endemic Infections in Wildlife: Epidemiology, Ecology, & Management in a Changing World)
  • Article
  • Open Access
13 Citations
3,584 Views
14 Pages

Novel Quantitative Assay to Describe In Vitro Bovine Mastitis Bacterial Pathogen Inhibition by Non-aureus Staphylococci

  • Bruno Toledo-Silva,
  • Lisa Beuckelaere,
  • Anneleen De Visscher,
  • Chloë Geeroms,
  • Evelyne Meyer,
  • Sofie Piepers,
  • Damien Thiry,
  • Freddy Haesebrouck and
  • Sarne De Vliegher

18 February 2022

In this paper, we describe a new quantitative method to evaluate and quantify in vitro growth inhibition of mastitis-related bacteria. Colony-forming units of Staphylococcus (S.) aureus (n = 10), Escherichia (E.) coli (n = 10), and Streptococcus (S.)...

(This article belongs to the Section Bacterial Pathogens)
  • Comment
  • Open Access
5 Citations
3,108 Views
3 Pages

18 February 2022

Currently, six species and two genetic variants within Babesia genus have been confirmed as human pathogens. Babesia bovis and Babesia bigemina are causative agents of bovine babesiosis, and, in spite of the worldwide distribution of those species an...

(This article belongs to the Special Issue Babesia and Human Babesiosis)
  • Article
  • Open Access
6 Citations
4,229 Views
9 Pages

An Experimental Evaluation of Toxicity Effects of Sodium Chloride on Oviposition, Hatching and Larval Development of Aedes albopictus

  • Xiang Guo,
  • Siyun Zhou,
  • Jing Wu,
  • Xiaoqing Zhang,
  • Yuji Wang,
  • Zixuan Li,
  • Xiao-Guang Chen and
  • Xiaohong Zhou

18 February 2022

Dengue virus, one of the most important mosquito-borne viruses, has shown a sharp upward trend, spreading around the world in recent years. Control of vectors Aedes aegypti and Ae. albopictus remains crucial for blocking dengue transmission. The leth...

(This article belongs to the Special Issue Mosquito-Borne Diseases: Novel Control Strategies)
  • Article
  • Open Access
6 Citations
3,560 Views
9 Pages

Evaluation of Eosinophilic Cationic Protein as a Marker of Alveolar and Cystic Echinococcosis

  • Julian Frederic Hotz,
  • Klaus Kaczirek,
  • Stefan Stremitzer,
  • Fredrik Waneck,
  • Herbert Auer,
  • Thomas Perkmann,
  • Manuel Kussmann,
  • Philipp Karl Bauer,
  • Rui-Yang Chen and
  • Heimo Lagler
  • + 3 authors

18 February 2022

Echinococcosis is a neglected zoonotic disease and a worldwide public health problem caused by infection with the larval stages of taeniid cestodes of the genus Echinococcus. In vitro studies have demonstrated a protoscolecidal effect of eosinophilic...

(This article belongs to the Special Issue Alveolar Echinococcosis: Joining Hands to Tackle a Lethal Parasitosis)
  • Communication
  • Open Access
12 Citations
3,971 Views
11 Pages

Intra-Palpebral Tuberculin Skin Test and Interferon Gamma Release Assay in Diagnosing Tuberculosis Due to Mycobacterium caprae in European Bison (Bison bonasus)

  • Anna Didkowska,
  • Blanka Orłowska,
  • Monika Krajewska-Wędzina,
  • Michał Krzysiak,
  • Małgorzata Bruczyńska,
  • Jan Wiśniewski,
  • Daniel Klich,
  • Wanda Olech and
  • Krzysztof Anusz

17 February 2022

Despite the threat posed by tuberculosis (TB) to the protected European bison (Bison bonasus), no validated TB tests exist for this species. This pilot study evaluates two tests based on detecting cellular immunity for this purpose: interferon gamma...

(This article belongs to the Special Issue Emerging and Endemic Infections in Wildlife: Epidemiology, Ecology, & Management in a Changing World)
  • Article
  • Open Access
7 Citations
4,502 Views
18 Pages

Deciphering the Interactions of SARS-CoV-2 Proteins with Human Ion Channels Using Machine-Learning-Based Methods

  • Nupur S. Munjal,
  • Dikscha Sapra,
  • K. T. Shreya Parthasarathi,
  • Abhishek Goyal,
  • Akhilesh Pandey,
  • Manidipa Banerjee and
  • Jyoti Sharma

17 February 2022

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is accountable for the protracted COVID-19 pandemic. Its high transmission rate and pathogenicity led to health emergencies and economic crisis. Recent studies pertaining to the understandi...

(This article belongs to the Special Issue Viral Pathogenesis and Immunity)
  • Review
  • Open Access
17 Citations
4,999 Views
14 Pages

17 February 2022

One of the adaptations of nematodes, which allows long-term survival in the host, is the production of proteins with immunomodulatory properties. The parasites secrete numerous homologs of human immune mediators, such as macrophage migration inhibito...

(This article belongs to the Special Issue Immune Response of the Host and Vaccine Development)
  • Article
  • Open Access
33 Citations
5,963 Views
12 Pages

SARS-CoV-2 Infects Primary Neurons from Human ACE2 Expressing Mice and Upregulates Genes Involved in the Inflammatory and Necroptotic Pathways

  • Hussin A. Rothan,
  • Pratima Kumari,
  • Shannon Stone,
  • Janhavi P. Natekar,
  • Komal Arora,
  • Tabassum T. Auroni and
  • Mukesh Kumar

17 February 2022

Transgenic mice expressing human angiotensin-converting enzyme 2 under the cytokeratin 18 promoter (K18-hACE2) have been extensively used to investigate the pathogenesis and tissue tropism of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-...

(This article belongs to the Section Emerging Pathogens)
  • Correction
  • Open Access
2 Citations
1,955 Views
2 Pages

Correction: Tanida et al. Comparative Assessment of In-House Real-Time PCRs Targeting Enteric Disease-Associated Microsporidia in Human Stool Samples. Pathogens 2021, 10, 656

  • Konstantin Tanida,
  • Andreas Hahn,
  • Kirsten Alexandra Eberhardt,
  • Egbert Tannich,
  • Olfert Landt,
  • Simone Kann,
  • Torsten Feldt,
  • Fred Stephen Sarfo,
  • Veronica Di Cristanziano and
  • Ulrike Loderstädt
  • + 1 author

17 February 2022

In the original publication [...]

(This article belongs to the Special Issue Molecular Diagnostics for Infectious Diseases)
  • Article
  • Open Access
6 Citations
3,815 Views
15 Pages

An Improvement in Diagnostic Blood Culture Conditions Allows for the Rapid Detection and Isolation of the Slow Growing Pathogen Yersinia pestis

  • Efi Makdasi,
  • Yafit Atiya-Nasagi,
  • David Gur,
  • Ayelet Zauberman,
  • Ofir Schuster,
  • Itai Glinert,
  • Shlomo Shmaya,
  • Elad Milrot,
  • Haim Levy and
  • Orly Laskar
  • + 3 authors

16 February 2022

Plague, caused by the human pathogen Yersinia pestis, is a severe and rapidly progressing lethal disease that has caused millions of deaths globally throughout human history and still presents a significant public health concern, mainly in developing...

  • Article
  • Open Access
21 Citations
3,085 Views
13 Pages

16 February 2022

The global importance of the hemoparasite Theileria haneyi to equine health was recently shown by its resistance to imidocarb dipropionate (ID) and its interference with T. equi clearance by ID in some co-infected horses. Genetic characterization of...

(This article belongs to the Special Issue Detection and Control Strategies for Bovine Babesiosis and Equine Piroplasmosis)
  • Article
  • Open Access
6 Citations
3,806 Views
17 Pages

Patterns of Kdr-L995F Allele Emergence Alongside Detoxifying Enzymes Associated with Deltamethrin Resistance in Anopheles gambiae s.l. from North Cameroon

  • Josiane Etang,
  • Stanislas Elysée Mandeng,
  • Philippe Nwane,
  • Herman Parfait Awono-Ambene,
  • Jude D. Bigoga,
  • Wolfgang Eyisap Ekoko,
  • Achille Jerome Binyang,
  • Michael Piameu,
  • Lili Ranaise Mbakop and
  • Etienne Fondjo
  • + 8 authors

15 February 2022

Understanding how multiple insecticide resistance mechanisms occur in malaria vectors is essential for efficient vector control. This study aimed at assessing the evolution of metabolic mechanisms and Kdr L995F/S resistance alleles in Anopheles gambi...

(This article belongs to the Section Parasitic Pathogens)
  • Systematic Review
  • Open Access
21 Citations
7,418 Views
26 Pages

15 February 2022

In order to better understand transmission dynamics and appropriately target control and preventive measures, studies have aimed to identify who-infected-whom in actual outbreaks. Numerous reconstruction methods exist, each with their own assumptions...

  • Article
  • Open Access
11 Citations
4,180 Views
19 Pages

15 February 2022

Epidemiological models are important for the understanding of disease progression in plants and for the design of control strategies. Phytophthora ramorum, the pathogen responsible for the disease known as Sudden Oak Death, causes lethal infection on...

(This article belongs to the Special Issue Prevention and Management of Tree Diseases)
  • Article
  • Open Access
8 Citations
4,731 Views
19 Pages

Development of a Mouse Model to Explore CD4 T Cell Specificity, Phenotype, and Recruitment to the Lung after Influenza B Infection

  • Ajitanuj Rattan,
  • Chantelle L. White,
  • Sean Nelson,
  • Max Eismann,
  • Herbey Padilla-Quirarte,
  • Maryah A. Glover,
  • Thamotharampillai Dileepan,
  • Bindumadhav M. Marathe,
  • Elena A. Govorkova and
  • Andrea J. Sant
  • + 2 authors

15 February 2022

The adaptive T cell response to influenza B virus is understudied, relative to influenza A virus, for which there has been considerable attention and progress for many decades. Here, we have developed and utilized the C57BL/6 mouse model of intranasa...

(This article belongs to the Topic Strategies for Prevention and Control of Influenza)
  • Review
  • Open Access
21 Citations
9,753 Views
18 Pages

14 February 2022

This narrative review aims to describe Angiostrongylus vasorum-induced hemostatic dysfunction of dogs with emphasis on clinical and laboratory findings as well as potential therapeutic strategies for the bleeding patient. Canine angiostrongylosis (CA...

(This article belongs to the Section Parasitic Pathogens)
  • Article
  • Open Access
28 Citations
4,656 Views
15 Pages

Suppression of Grape White Rot Caused by Coniella vitis Using the Potential Biocontrol Agent Bacillus velezensis GSBZ09

  • Xiangtian Yin,
  • Tinggang Li,
  • Xilong Jiang,
  • Xiaoning Tang,
  • Jiakui Zhang,
  • Lifang Yuan and
  • Yanfeng Wei

14 February 2022

Grape white rot caused by Coniella vitis is prevalent in almost all grapevines worldwide and results in a yield loss of 10–20% annually. Bacillus velezensis is a reputable plant growth-promoting bacterial. Strain GSBZ09 was isolated from grapev...

(This article belongs to the Special Issue Fungal Pathogenicity Factors)
  • Article
  • Open Access
11 Citations
3,955 Views
12 Pages

First Report of Anuran Trypanosoma DNA in Flat-Tailed House Geckos (Reptilia: Gekkonidae) Collected from Southern Thailand: No Evidence as a Reservoir for Human Trypanosomatids

  • Prapimporn Toontong,
  • Sakone Sunantaraporn,
  • Sonthaya Tiawsirisup,
  • Theerakamol Pengsakul,
  • Rungfar Boonserm,
  • Atchara Phumee,
  • Padet Siriyasatien and
  • Kanok Preativatanyou

14 February 2022

Over the years, cases of autochthonous leishmaniasis have been dramatically increasing in Thailand. Recently, several publications have claimed certain species of the phlebotomine sand flies and biting midges potentially serve as natural vectors of L...

(This article belongs to the Topic Zoonoses in Tropical Countries)
  • Article
  • Open Access
14 Citations
4,815 Views
27 Pages

Proteomic Profiling and In Silico Characterization of the Secretome of Anisakis simplex Sensu Stricto L3 Larvae

  • Maciej Kochanowski,
  • Joanna Dąbrowska,
  • Mirosław Różycki,
  • Jacek Sroka,
  • Jacek Karamon,
  • Aneta Bełcik,
  • Weronika Korpysa-Dzirba and
  • Tomasz Cencek

14 February 2022

Anisakis simplex sensu stricto (s.s.) L3 larvae are one of the major etiological factors of human anisakiasis, which is one of the most important foodborne parasitic diseases. Nevertheless, to date, Anisakis secretome proteins, with important functio...

(This article belongs to the Special Issue Anisakiasis and Anisakidae)
  • Article
  • Open Access
5 Citations
4,296 Views
16 Pages

Was It Chikungunya? Laboratorial and Clinical Investigations of Cases Occurred during a Triple Arboviruses’ Outbreak in Rio de Janeiro, Brazil

  • Thiara Manuele Alves de Souza,
  • Raquel Curtinhas de Lima,
  • Victor Edgar Fiestas Solórzano,
  • Paulo Vieira Damasco,
  • Luiz José de Souza,
  • Juan Camilo Sanchez-Arcila,
  • Gabriel Macedo Costa Guimarães,
  • Iury Amâncio Paiva,
  • Monique da Rocha Queiroz Lima and
  • Flavia Barreto dos Santos
  • + 6 authors

14 February 2022

The co-circulation of chikungunya virus (CHIKV), dengue virus (DENV) and Zika virus (ZIKV) in Rio de Janeiro (RJ), Brazil, caused a challenging triple epidemic, as they share similar clinical signs and symptoms and geographical distribution. Here, we...

(This article belongs to the Special Issue Diagnostics and Surveillance of Arboviral Diseases)
  • Systematic Review
  • Open Access
42 Citations
6,134 Views
15 Pages

The Prevalence of Arcobacteraceae in Aquatic Environments: A Systematic Review and Meta-Analysis

  • Igor Venâncio,
  • Ângelo Luís,
  • Fernanda Domingues,
  • Mónica Oleastro,
  • Luísa Pereira and
  • Susana Ferreira

13 February 2022

Members of the family Arcobacteraceae are distributed widely in aquatic environments, and some of its species have been associated with human and animal illness. However, information about the diversity and distribution of Arcobacteraceae in differen...

  • Article
  • Open Access
8 Citations
4,005 Views
12 Pages

12 February 2022

Hepatitis B (HBV) is a major public health threat in Sierra Leone. Pregnant women are disproportionately impacted, yet little is known about the epidemiology of HBV in this group. We conducted a cross-sectional study of pregnant women aged ≥16 yea...

  • Perspective
  • Open Access
8 Citations
4,956 Views
6 Pages

Transmissible Cancer Evolution: The Under-Estimated Role of Environmental Factors in the “Perfect Storm” Theory

  • Sophie Tissot,
  • Anne-Lise Gérard,
  • Justine Boutry,
  • Antoine M. Dujon,
  • Tracey Russel,
  • Hannah Siddle,
  • Aurélie Tasiemski,
  • Jordan Meliani,
  • Rodrigo Hamede and
  • Frédéric Thomas
  • + 2 authors

12 February 2022

Although the true prevalence of transmissible cancers is not known, these atypical malignancies are likely rare in the wild. The reasons behind this rarity are only partially understood, but the “Perfect Storm hypothesis” suggests that tr...

(This article belongs to the Special Issue Infectious Causes of Cancers: A Novel Pathway to Integrate Oncogenic Processes with Host–Pathogen Theory and Evolutionary Biology)
  • Review
  • Open Access
18 Citations
5,479 Views
15 Pages

12 February 2022

(1) Background: Trichosporon species have emerged as important opportunistic fungal pathogens, with Trichosporon asahii being the leading and most frequent cause of invasive disease. (2) Methods: We performed a global review focused on invasive trich...

(This article belongs to the Special Issue Uncommon Candida and Other Opportunistic Yeast-Like Fungi: Diagnosis and Treatment)
  • Article
  • Open Access
5 Citations
3,320 Views
15 Pages

The C-Terminal Domain of Staphylococcus aureus Zinc Transport Protein AdcA Binds Plasminogen and Factor H In Vitro

  • Natália Salazar,
  • Bruno Bernardi Yamamoto,
  • Matilde Costa Lima de Souza,
  • Ludmila Bezerra da Silva,
  • Ana Paula Mattos Arêas and
  • Angela Silva Barbosa

12 February 2022

Bacterial acquisition of metals from a host is an essential attribute to facilitate survival and colonization within an infected organism. Staphylococcus aureus, a bacterial pathogen of medical importance, has evolved its strategies to acquire multip...

(This article belongs to the Special Issue Staphylococcus Infections in Humans and Animals)
  • Article
  • Open Access
20 Citations
3,743 Views
13 Pages

Evaluation of Serological Markers in Alveolar Echinococcosis Emphasizing the Correlation of PET-CTI Tracer Uptake with RecEm18 and Echinococcus-Specific IgG

  • Julian Frederic Hotz,
  • Lynn Peters,
  • Silke Kapp-Schwörer,
  • Frauke Theis,
  • Nina Eberhardt,
  • Andreas Essig,
  • Beate Grüner and
  • Jürgen Benjamin Hagemann

12 February 2022

Human alveolar echinococcosis (AE), which is caused by the cestode Echinococcus (E.) multilocularis, is an epidemiologically relevant issue in modern medicine and still poses a diagnostic and therapeutic challenge. Since diagnosis mainly relies on im...

(This article belongs to the Special Issue Alveolar Echinococcosis: Joining Hands to Tackle a Lethal Parasitosis)
  • Article
  • Open Access
28 Citations
3,815 Views
14 Pages

The pH Effects on SARS-CoV and SARS-CoV-2 Spike Proteins in the Process of Binding to hACE2

  • Yixin Xie,
  • Wenhan Guo,
  • Alan Lopez-Hernadez,
  • Shaolei Teng and
  • Lin Li

11 February 2022

COVID-19 has been threatening human health since the late 2019, and has a significant impact on human health and economy. Understanding SARS-CoV-2 and other coronaviruses is important to develop effective treatments for COVID-19 and other coronavirus...

  • Article
  • Open Access
8 Citations
9,120 Views
10 Pages

Longitudinal Monitoring of DNA Viral Loads in Transplant Patients Using Quantitative Metagenomic Next-Generation Sequencing

  • Ellen C. Carbo,
  • Anne Russcher,
  • Margriet E. M. Kraakman,
  • Caroline S. de Brouwer,
  • Igor A. Sidorov,
  • Mariet C. W. Feltkamp,
  • Aloys C. M. Kroes,
  • Eric C. J. Claas and
  • Jutte J. C. de Vries

11 February 2022

Introduction: Immunocompromised patients are prone to reactivations and (re-)infections of multiple DNA viruses. Viral load monitoring by single-target quantitative PCRs (qPCR) is the current cornerstone for virus quantification. In this study, a met...

(This article belongs to the Section Viral Pathogens)
  • Article
  • Open Access
11 Citations
6,275 Views
10 Pages

Inhibition of Influenza Virus Replication by Oseltamivir Derivatives

  • Renee W. Y. Chan,
  • Kin P. Tao,
  • Jiqing Ye,
  • Kevin K. Y. Lui,
  • Xiao Yang,
  • Cong Ma and
  • Paul K. S. Chan

11 February 2022

Characterized by the high morbidity and mortality and seasonal surge, the influenza virus (IV) remains a major public health challenge. Oseltamivir is commonly used as a first-line antiviral. As a neuraminidase inhibitor, it attenuates the penetratio...

(This article belongs to the Special Issue Fighting Flu—Recent Advances in Influenza Research)
  • Article
  • Open Access
5 Citations
2,323 Views
9 Pages

Factors Possibly Associated with Mortality in Intubated COVID-19 Patients: A Retrospective Study

  • Lilia Esther Ramírez-Plascencia,
  • Ana Paulina Vázquez-León,
  • Almendra Villaseñor-Magaña,
  • Marisela Correa-Valdéz,
  • Sandra Carrillo-Ibarra and
  • Sonia Sifuentes-Franco

11 February 2022

In Mexico, there is a high mortality rate among patients intubated because of COVID-19. The objective of this study was to investigate the associations of age, comorbidities, and biochemical parameters with the in-hospital mortality of COVID-19 patie...

(This article belongs to the Special Issue Viral Pathogenesis and Immunity)
  • Article
  • Open Access
5 Citations
3,446 Views
11 Pages

10 February 2022

Removal of genes coding for major parts of capsid (C), premembrane (prM), and envelope (E) proteins on the flavivirus genome aborts the production of infectious virus particles where the remaining genome forms a replicon that retains replicability in...

(This article belongs to the Section Vaccines and Therapeutic Developments)
  • Article
  • Open Access
16 Citations
6,112 Views
12 Pages

Campylobacteriosis, Shigellosis and Salmonellosis in Hospitalized Children with Acute Inflammatory Diarrhea in Georgia

  • Maia Metreveli,
  • Salome Bulia,
  • Iamze Shalamberidze,
  • Liana Tevzadze,
  • Shota Tsanava,
  • Juan Cruz Goenaga,
  • Kerstin Stingl and
  • Paata Imnadze

10 February 2022

This is the first study on campylobacteriosis carried out in Georgia. It targeted 382 hospitalized children with acute inflammatory diarrhea. The study was conducted between July 2020 to July 2021 based on the main infection clinic of the capital cit...

(This article belongs to the Collection Campylobacter Infections Collection)
  • Article
  • Open Access
21 Citations
6,623 Views
16 Pages

Fecal Microbiota Analysis in Cats with Intestinal Dysbiosis of Varying Severity

  • Nikolay Bugrov,
  • Pavel Rudenko,
  • Vladimir Lutsay,
  • Regina Gurina,
  • Andrey Zharov,
  • Nadiya Khairova,
  • Maria Molchanova,
  • Elena Krotova,
  • Marina Shopinskaya and
  • Irina Popova
  • + 1 author

10 February 2022

Recent studies have shown that the gut microbiota plays an important role in the pathogenesis of gastrointestinal diseases in various animal species. There are only limited data on the microbiome in cats with varying grades of dysbiosis. The purpose...

  • Article
  • Open Access
5 Citations
3,460 Views
15 Pages

Proteomic Analysis of Sporothrix schenckii Exposed to Oxidative Stress Induced by Hydrogen Peroxide

  • Dulce O. Saucedo-Campa,
  • Ana L. Martínez-Rocha,
  • Emmanuel Ríos-Castro,
  • Carlos A. Alba-Fierro,
  • Miguel A. Escobedo-Bretado,
  • Mayra Cuéllar-Cruz and
  • Estela Ruiz-Baca

10 February 2022

Sporothrix schenckii modulates the expression of its cell wall proteins (CWPs) in response to reactive oxygen species (ROS) generated by the phagocytic cells of the human host, which allows it to evade and escape the immune system. In this study, we...

(This article belongs to the Special Issue Identification and Infection of Sporothrix schenckii)
  • Article
  • Open Access
1 Citations
3,749 Views
16 Pages

Escherichia coli Strains Responsible for Cystitis in Female Pediatric Patients with Normal and Abnormal Urinary Tracts Have Different Virulence Profiles

  • Marta de Oliveira Domingos,
  • Silvio Marciano da Silva Junior,
  • Wagner Milanello,
  • Shirley Sizue Nakamura Nakano,
  • Marcia Regina Franzolin,
  • Luis Fernando dos Santos,
  • Kamila Oliveira Nunes,
  • Vaniky Duarte Marques,
  • Waldir P. Elias and
  • Roxane Maria Fontes Piazza
  • + 2 authors

10 February 2022

The role of uropathogenic Escherichia coli (UPEC) in colonization and infection of female patients with anatomical and functional abnormalities of the urinary system is elusive. In this study, the phenotype, genotype and the phylogeny of UPEC strains...

(This article belongs to the Section Bacterial Pathogens)
  • Article
  • Open Access
32 Citations
5,704 Views
13 Pages

Salivary miR-31-5p, miR-345-3p, and miR-424-3p Are Reliable Biomarkers in Patients with Oral Squamous Cell Carcinoma

  • Beáta Scholtz,
  • József Horváth,
  • Ildikó Tar,
  • Csongor Kiss and
  • Ildikó J. Márton

9 February 2022

If not detected early, oral squamous cell carcinoma (OSCC) has very poor prognosis, emphasizing the need for reliable early diagnostics. Saliva is considered a promising surrogate biosample for OSCC detection, because it comes into contact with many...

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Pathogens - ISSN 2076-0817