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Epigenomes, Volume 9, Issue 3

September 2025 - 14 articles

Cover Story: Cellular metabolism influences the epigenome via crucial cofactors, including folate, vitamins B12/B6, and metabolic intermediates such as acetyl-CoA, α-ketoglutarate, and related molecules, which are instrumental in regulating diverse epigenetic processes. Concurrently, bioactive compounds such as polyphenols possess the capacity to modulate a broad spectrum of chromatin-modifying enzymes. In this context, well-balanced nutrition emerges as an essential requisite for the maintenance of not only metabolic integrity but also epigenetic homeostasis, and diet stands as one of the most important primary external factors influencing the epigenetic landscape and transcriptional gene regulation. View this paper

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Article

1,000 Views

17 Pages

Epigenomic Interactions Between Chronic Pain and Recurrent Pressure Injuries After Spinal Cord Injury

Letitia Y. Graves,
Melissa R. Alcorn,
E. Ricky Chan,
Katelyn Schwartz,
M. Kristi Henzel,
Marinella Galea,
Anna M. Toth,
Christine M. Olney and
Kath M. Bogie

Epigenomes2025, 9(3), 26;https://doi.org/10.3390/epigenomes9030026

23 July 2025

Background/Objectives: This study investigated variations in DNA methylation patterns associated with chronic pain and propensity for recurrent pressure injuries (PrI) in persons with spinal cord injury (SCI). Methods: Whole blood was collected from...

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Article

1,192 Views

17 Pages

Exploring Epigenetic Ageing Using Direct Methylome Sequencing

Elena-Cristina Găitănaru,
Roua Gabriela Popescu,
Andreea-Angelica Stroe,
Sergiu Emil Georgescu and
George Cătălin Marinescu

Epigenomes2025, 9(3), 25;https://doi.org/10.3390/epigenomes9030025

14 July 2025

Background/Objectives: Advances in nanopore sequencing have opened new avenues for studying DNA methylation at single-base resolution, yet their application in epigenetic ageing research remains underdeveloped. Methods: We present a novel framework t...

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Article

949 Views

24 Pages

Trends in DNA Methylation over Time Between Parous and Nulliparous Young Women

Su Chen,
John W. Holloway,
Wilfried Karmaus,
Hongmei Zhang,
S. Hasan Arshad and
Susan Ewart

Epigenomes2025, 9(3), 24;https://doi.org/10.3390/epigenomes9030024

10 July 2025

Background/Objectives: The experience of pregnancy and parturition has been associated with long-term health effects in mothers, imparting protective effects against some diseases while the risk of other diseases is increased. The mechanisms that dri...

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Review

1 Citations

1,543 Views

17 Pages

The Fundamental Role of Nutrients for Metabolic Balance and Epigenome Integrity Maintenance

Ana Paula de Souza,
Vitor Marinho and
Marcelo Rocha Marques

Epigenomes2025, 9(3), 23;https://doi.org/10.3390/epigenomes9030023

9 July 2025

Epigenetic modifications act as crucial regulators of gene activity and are influenced by both internal and external environmental factors, with diet being the most impactful external factor. On the other hand, cellular metabolism encompasses a compl...

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