Epigenetics Meets Immunology: Mechanisms, Crosstalk, and Therapeutic Implications
A special issue of Epigenomes (ISSN 2075-4655).
Deadline for manuscript submissions: 31 July 2026 | Viewed by 71
Special Issue Editor
Special Issue Information
Dear Colleagues,
The intricate crosstalk between epigenetic regulation and immune function has emerged as a pivotal area of investigation in both basic and translational research. Epigenetic mechanisms—including DNA methylation, histone modifications, chromatin remodeling, and non-coding RNAs—play fundamental roles in governing immune cell development, differentiation, activation, and functional plasticity. In turn, immune signaling pathways can reshape the epigenetic landscape, particularly in response to inflammation, infection, cancer, and autoimmune conditions.
This Special Issue aims to explore the mechanistic and functional intersections between epigenetics and immunology, with a focus on how these interactions influence immune regulation in health and disease. We welcome a broad range of contributions, including original research articles, reviews, and perspectives, that investigate how epigenetic mechanisms shape innate and adaptive immune responses, memory formation, immune tolerance, and dysfunction.
Topics of interest include, but are not limited to, the following:
- Immune surveillance and recognition of epigenetic marks;
- Epigenetic regulation of immune cell development and function;
- Chromatin dynamics in innate and adaptive immunity;
- Epigenetic plasticity in response to inflammation and environmental cues;
- Mechanisms of tumor immune evasion driven by epigenetic alterations;
- Tools and technologies for epigenetic editing in immune cells;
- Epigenetic-based therapeutic strategies for immunological disorders and cancer.
This Special Issue aims to serve as a platform for interdisciplinary dialogue and discovery, bringing together insights from epigenetics and immunology to foster the development of innovative diagnostic and therapeutic approaches.
Dr. Yalong Wang
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Epigenomes is an international peer-reviewed open access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- epigenetics
- immunology
- tumor immunology
- immunological disorders
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