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Background:
Communication

Genetic Polymorphisms of 5-HT Receptors and Antipsychotic-Induced Metabolic Dysfunction in Patients with Schizophrenia

by
Diana Z. Paderina
1,
Anastasiia S. Boiko
1,
Ivan V. Pozhidaev
1,
Anna V. Bocharova
2,
Irina A. Mednova
1,
Olga Yu. Fedorenko
1,
Elena G. Kornetova
1,3,
Anton J.M. Loonen
4,*,
Arkadiy V. Semke
1,
Nikolay A. Bokhan
1,3 and
Svetlana A. Ivanova
1,3
1
Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, 634014 Tomsk, Russia
2
Research Institute of Medical Genetics, Tomsk National Research Medical Center of the Russian Academy of Sciences, 634050 Tomsk, Russia
3
Siberian State Medical University, 634050 Tomsk, Russia
4
Unit of PharmacoTherapy, -Epidemiology & -Economics, Groningen Research Institute of Pharmacy, University of Groningen, 9713AV Groningen, The Netherlands
*
Author to whom correspondence should be addressed.
J. Pers. Med. 2021, 11(3), 181; https://doi.org/10.3390/jpm11030181
Submission received: 4 February 2021 / Revised: 1 March 2021 / Accepted: 2 March 2021 / Published: 5 March 2021
(This article belongs to the Special Issue Psychoneurobiology Research and Personalized Treatment of Schizophrenia)
Review Reports Versions Notes

Abstract

Background: Antipsychotic-induced metabolic syndrome (MetS) is a multifactorial disease with a genetic predisposition. Serotonin and its receptors are involved in antipsychotic-drug-induced metabolic disorders. The present study investigated the association of nine polymorphisms in the four 5-hydroxytryptamine receptor (HTR) genes HTR1A, HTR2A, HTR3A, and HTR2C and the gene encoding for the serotonin transporter SLC6A4 with MetS in patients with schizophrenia. Methods: A set of nine single-nucleotide polymorphisms of genes of the serotonergic system was investigated in a population of 475 patients from several Siberian regions (Russia) with a clinical diagnosis of schizophrenia. Genotyping was performed and the results were analyzed using chi-square tests. Results: Polymorphic variant rs521018 (HTR2C) was associated with higher body mass index in patients receiving long-term antipsychotic therapy, but not with drug-induced metabolic syndrome. Rs1150226 (HTR3A) was also associated but did not meet Hardy–Weinberg equilibrium. Conclusions: Our results indicate that allelic variants of HTR2C genes may have consequences on metabolic parameters. MetS may have too complex a mechanistic background to be studied without dissecting the syndrome into its individual (causal) components.
Keywords: schizophrenia; antipsychotics; body mass index; weight gain; metabolic syndrome; serotonin; genes; pharmacogenetics schizophrenia; antipsychotics; body mass index; weight gain; metabolic syndrome; serotonin; genes; pharmacogenetics

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MDPI and ACS Style

Paderina, D.Z.; Boiko, A.S.; Pozhidaev, I.V.; Bocharova, A.V.; Mednova, I.A.; Fedorenko, O.Y.; Kornetova, E.G.; Loonen, A.J.M.; Semke, A.V.; Bokhan, N.A.; et al. Genetic Polymorphisms of 5-HT Receptors and Antipsychotic-Induced Metabolic Dysfunction in Patients with Schizophrenia. J. Pers. Med. 2021, 11, 181. https://doi.org/10.3390/jpm11030181

AMA Style

Paderina DZ, Boiko AS, Pozhidaev IV, Bocharova AV, Mednova IA, Fedorenko OY, Kornetova EG, Loonen AJM, Semke AV, Bokhan NA, et al. Genetic Polymorphisms of 5-HT Receptors and Antipsychotic-Induced Metabolic Dysfunction in Patients with Schizophrenia. Journal of Personalized Medicine. 2021; 11(3):181. https://doi.org/10.3390/jpm11030181

Chicago/Turabian Style

Paderina, Diana Z., Anastasiia S. Boiko, Ivan V. Pozhidaev, Anna V. Bocharova, Irina A. Mednova, Olga Yu. Fedorenko, Elena G. Kornetova, Anton J.M. Loonen, Arkadiy V. Semke, Nikolay A. Bokhan, and et al. 2021. "Genetic Polymorphisms of 5-HT Receptors and Antipsychotic-Induced Metabolic Dysfunction in Patients with Schizophrenia" Journal of Personalized Medicine 11, no. 3: 181. https://doi.org/10.3390/jpm11030181

APA Style

Paderina, D. Z., Boiko, A. S., Pozhidaev, I. V., Bocharova, A. V., Mednova, I. A., Fedorenko, O. Y., Kornetova, E. G., Loonen, A. J. M., Semke, A. V., Bokhan, N. A., & Ivanova, S. A. (2021). Genetic Polymorphisms of 5-HT Receptors and Antipsychotic-Induced Metabolic Dysfunction in Patients with Schizophrenia. Journal of Personalized Medicine, 11(3), 181. https://doi.org/10.3390/jpm11030181

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