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Article

Blood Biomarkers for Assessing Headaches in Healthcare Workers after Wearing Biological Personal Protective Equipment in a COVID-19 Field Hospital

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Advanced Clinical Simulation Centre, Advanced Life Support Unit, Emergency Medical Services, Faculty of Medicine, Universidad de Valladolid, 47005 Valladolid, Spain
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Emergency Department, Hospital Universitario Rio Hortega de Valladolid, Gerencia Regional de Salud de Castilla y León (SACYL), c/Dulzaina, 2, 47012 Valladolid, Spain
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C.S. de Tordesillas, Gerencia de Atención Primaria de Valladolid Oeste, Gerencia Regional de Salud de Castilla y León (SACYL), Crta. de Valladolid s/n, 47100 Tordesillas, Valladolid, Spain
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Data Analysis Unit, Health Research Institute, Hospital de la Princesa, Madrid (IIS-IP), C/Diego de León, 62, 28006 Madrid, Spain
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Faculty of Health Sciences, Universidad de Castilla la Mancha, 45600 Talavera de la Reina, Spain
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C.S. Delicias I Gerencia de Atención Primaria de Valladolid Oeste, Gerencia Regional de Salud de Castilla y León (SACYL), Pª Juan Carlos I, 18, 47013 Valladolid, Spain
*
Author to whom correspondence should be addressed.
Martín-Rodríguez and Sanz-García are joint first authors.
J. Pers. Med. 2021, 11(1), 27; https://doi.org/10.3390/jpm11010027
Received: 6 December 2020 / Revised: 22 December 2020 / Accepted: 30 December 2020 / Published: 4 January 2021
(This article belongs to the Special Issue COVID-19 Related Complications)
The coronavirus disease 2019 (COVID-19) has led to a pandemic, which among other things, has highlighted biosafety as a key cornerstone in the management of disease transmission. The aim of this work was to analyze the role played by different blood biomarkers in predicting the appearance of headaches in healthcare workers wearing personal protective equipment (PPE) in a COVID-19 treatment unit. A prospective cohort study of 38 healthcare workers was performed during April 2020. Blood analysis, performed just before the start of a 4 hour shift, was carried out on all volunteers equipped with PPE. At the end of their shifts and after decontamination, they were asked if they had suffered from headache in order to obtain a binary outcome. The baseline creatinine value reflected a specific odds ratio of 241.36 (95% CI: 2.50–23,295.43; p = 0.019) and an area under the curve (AUC) value of 0.737 (95%CI: 0.57–0.90; p < 0.01). Blood creatinine is a good candidate for predicting the appearance of a de novo headache in healthcare workers after wearing PPE for four hours in a COVID-19 unit. View Full-Text
Keywords: biomarker; COVID-19; headache; occupational health; personal protective equipment biomarker; COVID-19; headache; occupational health; personal protective equipment
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MDPI and ACS Style

Martín-Rodríguez, F.; López-Izquierdo, R.; Portillo Rubiales, R.M.; Fadrique Millán, L.N.; Carbajosa Rodríguez, V.; Sanz-García, A.; Ortega Rabbione, G.; Polonio-López, B.; Castro Villamor, M.Á.; Martín-Conty, J.L. Blood Biomarkers for Assessing Headaches in Healthcare Workers after Wearing Biological Personal Protective Equipment in a COVID-19 Field Hospital. J. Pers. Med. 2021, 11, 27. https://doi.org/10.3390/jpm11010027

AMA Style

Martín-Rodríguez F, López-Izquierdo R, Portillo Rubiales RM, Fadrique Millán LN, Carbajosa Rodríguez V, Sanz-García A, Ortega Rabbione G, Polonio-López B, Castro Villamor MÁ, Martín-Conty JL. Blood Biomarkers for Assessing Headaches in Healthcare Workers after Wearing Biological Personal Protective Equipment in a COVID-19 Field Hospital. Journal of Personalized Medicine. 2021; 11(1):27. https://doi.org/10.3390/jpm11010027

Chicago/Turabian Style

Martín-Rodríguez, Francisco, Raúl López-Izquierdo, Raquel M. Portillo Rubiales, Laura N. Fadrique Millán, Virginia Carbajosa Rodríguez, Ancor Sanz-García, Guillermo Ortega Rabbione, Begoña Polonio-López, Miguel Á. Castro Villamor, and José L. Martín-Conty. 2021. "Blood Biomarkers for Assessing Headaches in Healthcare Workers after Wearing Biological Personal Protective Equipment in a COVID-19 Field Hospital" Journal of Personalized Medicine 11, no. 1: 27. https://doi.org/10.3390/jpm11010027

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