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Diagnostics, Volume 13, Issue 21

2023 November-1 - 103 articles

Cover Story: Millions of persons experience mild traumatic brain injuries (mTBI) each year, yet there is no widely accepted systematic method to evaluate this patient population. Individuals experiencing concussion may have long-term symptoms and sequelae. Assessment of mTBI in the Emergency Department varies and follow-up is often limited. Neuroimaging results are frequently normal. There are few effective medical interventions for mTBI. Accurate, sensitive and rapid point-of-care blood biomarker tests for mTBI have the potential to be useful in improving prediction of prognosis, outcome and efficacy of treatment. Further, a large database might be created using biomarkers and other key information gathered on patients with mTBI. Such a database could yield objective, consistent criteria to better understand mTBI. View this paper
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Articles (103)

  • Interesting Images
  • Open Access
4 Citations
5,450 Views
3 Pages

Osmotic Demyelination Syndrome: A Rare Clinical Image

  • Prishita Koul,
  • Pallavi Harjpal and
  • Raghuveer Raghumahanti

6 November 2023

The term “Osmotic Demyelination Syndrome” (ODS) is synonymous with central pontine myelinolysis (CPM), denoting a condition characterised by brain damage, particularly affecting the white matter tracts of the pontine region. This damage a...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Article
  • Open Access
2 Citations
2,161 Views
10 Pages

Blunt Trauma in Children: Efficacy and Safety of Transarterial Embolization, 10-Year Experiences in a Single Trauma Center

  • Seyoung Ko,
  • Hoon Kwon,
  • Chang Won Kim,
  • Hojun Lee and ,
  • Jae Hun Kim,
  • Hohyun Kim and
  • Chan Ik Park
  • + 2 authors+ 0 author

6 November 2023

Background: Transcatheter arterial embolization (TAE) is an established approach for controlling hemorrhage in adults with acute abdominal and pelvic trauma. However, its application in pediatric trauma is not well established. This study aimed to ev...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Article
  • Open Access
2 Citations
3,465 Views
18 Pages

User Perceptions of Avatar-Based Patient Monitoring for Intensive Care Units: An International Exploratory Sequential Mixed-Methods Study

  • Justyna Lunkiewicz,
  • Greta Gasciauskaite,
  • Tadzio Raoul Roche,
  • Samira Akbas and ,
  • Christoph B. Nöthiger,
  • Michael T. Ganter,
  • Patrick Meybohm,
  • Sebastian Hottenrott,
  • Kai Zacharowski and
  • Lisa Bergauer
  • + 10 authors+ 5 authors

6 November 2023

Visual Patient Avatar ICU is an innovative approach to patient monitoring, enhancing the user’s situation awareness in intensive care settings. It dynamically displays the patient’s current vital signs using changes in color, shape, and a...

(This article belongs to the Special Issue Point-of-Care Diagnostics Technology and Applications)
  • Article
  • Open Access
7 Citations
2,803 Views
15 Pages

A Severity Comparison between Italian and Israeli Rett Syndrome Cohorts

  • Alberto Romano,
  • Meir Lotan and
  • Rosa Angela Fabio

6 November 2023

Rett syndrome (RTT) is a neurodevelopmental disorder marked by profound cognitive, communication, and motor impairments. Despite identified genotype/phenotype connections, the extent of clinical severity varies even among individuals sharing the same...

(This article belongs to the Section Pathology and Molecular Diagnostics)
  • Article
  • Open Access
8 Citations
4,334 Views
22 Pages

6 November 2023

In this study, a small sample of patients’ neuromonitoring data was analyzed using machine learning (ML) tools to provide proof of concept for quantifying complex signals. Intraoperative neurophysiological monitoring (IONM) is a valuable asset...

(This article belongs to the Special Issue Applications of Artificial Intelligence in Healthcare Monitoring)
  • Viewpoint
  • Open Access
26 Citations
7,398 Views
12 Pages

6 November 2023

With the miniaturization of ultrasound and the development of artificial intelligence, its application in disaster scenes and pre-hospital emergency care has become more and more common. This study summarizes the literature on portable ultrasound in...

(This article belongs to the Section Point-of-Care Diagnostics and Devices)
  • Article
  • Open Access
10 Citations
3,129 Views
14 Pages

Surgical Phase Duration in Robot-Assisted Partial Nephrectomy: A Surgical Data Science Exploration for Clinical Relevance

  • Pieter De Backer,
  • Maria Peraire Lores,
  • Meret Demuynck,
  • Federico Piramide and ,
  • Jente Simoens,
  • Tim Oosterlinck,
  • Wouter Bogaert,
  • Chi Victor Shan,
  • Karel Van Regemorter and
  • Alexandre Mottrie
  • + 13 authors+ 8 authors

5 November 2023

(1) Background: Surgical phases form the basic building blocks for surgical skill assessment, feedback, and teaching. The phase duration itself and its correlation with clinical parameters at diagnosis have not yet been investigated. Novel commercial...

(This article belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)
  • Article
  • Open Access
17 Citations
4,124 Views
17 Pages

Diagnostic Performance of an Artificial Intelligence Model Based on Contrast-Enhanced Ultrasound in Patients with Liver Lesions: A Comparative Study with Clinicians

  • Marinela-Cristiana Urhuț,
  • Larisa Daniela Săndulescu,
  • Costin Teodor Streba,
  • Mădălin Mămuleanu and ,
  • Adriana Ciocâlteu,
  • Sergiu Marian Cazacu and
  • Suzana Dănoiu
  • + 2 authors+ 0 author

5 November 2023

Contrast-enhanced ultrasound (CEUS) is widely used in the characterization of liver tumors; however, the evaluation of perfusion patterns using CEUS has a subjective character. This study aims to evaluate the accuracy of an automated method based on...

(This article belongs to the Special Issue Diagnostic Imaging of Liver Diseases)
  • Article
  • Open Access
7 Citations
2,686 Views
16 Pages

Building Automation Pipeline for Diagnostic Classification of Sporadic Odontogenic Keratocysts and Non-Keratocysts Using Whole-Slide Images

  • Samahit Mohanty,
  • Divya B. Shivanna,
  • Roopa S. Rao,
  • Madhusudan Astekar and ,
  • Chetana Chandrashekar,
  • Raghu Radhakrishnan,
  • Shylaja Sanjeevareddygari,
  • Vijayalakshmi Kotrashetti and
  • Prashant Kumar
  • + 4 authors+ 0 author

4 November 2023

The microscopic diagnostic differentiation of odontogenic cysts from other cysts is intricate and may cause perplexity for both clinicians and pathologists. Of particular interest is the odontogenic keratocyst (OKC), a developmental cyst with unique...

(This article belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)
  • Review
  • Open Access
16 Citations
18,007 Views
17 Pages

Diagnostic Approach to Lower Limb Entrapment Neuropathies: A Narrative Literature Review

  • Nicu Cătălin Drăghici,
  • Vitalie Văcăraș,
  • Roxana Bolchis,
  • Atamyrat Bashimov and ,
  • Diana Maria Domnița,
  • Silvina Iluț,
  • Livia Livinț Popa,
  • Tudor Dimitrie Lupescu and
  • Dafin Fior Mureșanu
  • + 4 authors+ 0 author

4 November 2023

Entrapment neuropathies of the lower limb are a misunderstood and underdiagnosed group of disorders, characterized by pain and dysesthesia, muscular weakness, and specific provoking movements on physical examination. The most frequent of these syndro...

(This article belongs to the Special Issue Peripheral Neuropathy and Related Diseases: Symptoms, Diagnosis, and Treatment)
  • Review
  • Open Access
15 Citations
3,602 Views
19 Pages

MiRNAs and Their Role in Venous Thromboembolic Complications

  • Ilgiz Gareev,
  • Valentin Pavlov,
  • Weijie Du and
  • Baofeng Yang

4 November 2023

Venous thromboembolic complications (VTCs), which include deep vein thrombosis (DVT) and pulmonary embolism (PE), have remained a pressing problem in modern clinical medicine for a long time. Despite the already wide arsenal of modern methods for dia...

(This article belongs to the Section Pathology and Molecular Diagnostics)
  • Article
  • Open Access
32 Citations
2,357 Views
20 Pages

3 November 2023

Epileptic seizure detection has undergone progressive advancements since its conception in the 1970s. From proof-of-concept experiments in the latter part of that decade, it has now become a vibrant area of clinical and laboratory research. In an eff...

(This article belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)
  • Article
  • Open Access
5 Citations
2,977 Views
15 Pages

Deep Learning Framework with Multi-Head Dilated Encoders for Enhanced Segmentation of Cervical Cancer on Multiparametric Magnetic Resonance Imaging

  • Reza Kalantar,
  • Sebastian Curcean,
  • Jessica M. Winfield,
  • Gigin Lin and ,
  • Christina Messiou,
  • Matthew D. Blackledge and
  • Dow-Mu Koh
  • + 2 authors+ 0 author

3 November 2023

T2-weighted magnetic resonance imaging (MRI) and diffusion-weighted imaging (DWI) are essential components of cervical cancer diagnosis. However, combining these channels for the training of deep learning models is challenging due to image misalignme...

(This article belongs to the Special Issue Deep Learning for Early Detection of Cancer)
  • Article
  • Open Access
5 Citations
3,134 Views
17 Pages

Machine Learning and Radiomics of Bone Scintigraphy: Their Role in Predicting Recurrence of Localized or Locally Advanced Prostate Cancer

  • Yu-De Wang,
  • Chi-Ping Huang,
  • You-Rong Yang,
  • Hsi-Chin Wu and ,
  • Yu-Ju Hsu,
  • Yi-Chun Yeh,
  • Pei-Chun Yeh,
  • Kuo-Chen Wu and
  • Chia-Hung Kao
  • + 4 authors+ 0 author

3 November 2023

Background: Machine-learning (ML) and radiomics features have been utilized for survival outcome analysis in various cancers. This study aims to investigate the application of ML based on patients’ clinical features and radiomics features deriv...

(This article belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)
  • Article
  • Open Access
11 Citations
3,584 Views
13 Pages

Are Tumor Marker Tests Applied Appropriately in Clinical Practice? A Healthcare Claims Data Analysis

  • Sabrina M. Stollberg,
  • Markus Näpflin,
  • Michael Nagler and
  • Carola A. Huber

3 November 2023

Tumor markers (TM) are crucial in the monitoring of cancer treatment. However, inappropriate requests for screening reasons have a high risk of false positive and negative findings, which can lead to patient anxiety and unnecessary follow-up examinat...

(This article belongs to the Section Clinical Laboratory Medicine)
  • Article
  • Open Access
3 Citations
2,890 Views
17 Pages

Successful Implementation of Image-Guided Pencil-Beam Scanning Proton Therapy in Medulloblastomas

  • Anindita Das,
  • Utpal Gaikwad,
  • Ganapathy Krishnan,
  • Adhithyan Rajendran and ,
  • Sushama Patil,
  • Preethi Subramaniam,
  • Uday Krishna,
  • Manoj G. Wakde,
  • Srinivas Chilukuri and
  • Rakesh Jalali
  • + 5 authors+ 0 author

3 November 2023

Medulloblastoma is the most common malignant brain tumour in children, while much rarer in adults. Although the prognosis and outcomes have greatly improved in the era of modern multidisciplinary management, long-term treatment-induced toxicities are...

(This article belongs to the Special Issue Medulloblastoma—Existing and Evolving Landscape)
  • Interesting Images
  • Open Access
4 Citations
3,161 Views
7 Pages

Obstructed Hemi-Vagina with Ipsilateral Renal Agenesis Syndrome in Adulthood: A Diagnostic Challenge

  • Alexandros Loukas Grammatis,
  • Femi Ajibade,
  • Dinuke Warakaulle and
  • Tunde Dada

3 November 2023

A patient in her early 20s presented with constant and progressive lower abdominal and back pain, mainly on the right side of the abdomen, purulent vaginal discharge and pyrexia. A radiological assessment revealed a possible tubo-ovarian abscess and...

(This article belongs to the Topic Diagnosis, Management, and Prognostic Assessment of Chronic Disease)
  • Article
  • Open Access
3 Citations
3,934 Views
15 Pages

Structural and Functional Changes in Non-Paraneoplastic Autoimmune Retinopathy

  • Amir Akhavanrezayat,
  • Anadi Khatri,
  • Neil Gregory L. Onghanseng,
  • Muhammad Sohail Halim and ,
  • Christopher Or,
  • Nripun Sredar,
  • Moataz Razeen,
  • Murat Hasanreisoglu,
  • Jonathan Regenold and
  • Quan Dong Nguyen
  • + 21 authors+ 16 authors

3 November 2023

Background: To describe longitudinal changes in patients with non-paraneoplastic autoimmune retinopathy (npAIR) by utilizing different diagnostic modalities/tests. Methods: The index study is a retrospective longitudinal review of sixteen eyes of eig...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Article
  • Open Access
11 Citations
3,601 Views
13 Pages

2 November 2023

We developed a novel quantification method named “shape feature” by combining the features of amyloid positron emission tomography (PET) and brain magnetic resonance imaging (MRI) and evaluated its significance in predicting the conversio...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Article
  • Open Access
10 Citations
2,293 Views
16 Pages

2 November 2023

Background: This paper aimed to study the association of type D personality, coping strategies, and cognitive appraisal with annual prognosis after a percutaneous coronary intervention (PCI) in patients with coronary artery disease (CAD). Methods: Th...

(This article belongs to the Section Pathology and Molecular Diagnostics)
  • Article
  • Open Access
12 Citations
3,470 Views
12 Pages

2 November 2023

Trabeculectomy has traditionally been upheld as the gold standard in glaucoma surgery, but recent advancements, including the PRESERFLO® MicroShunt, have introduced less invasive techniques to mitigate complications and reduce intraocular pressure (I...

(This article belongs to the Section Biomedical Optics)
  • Systematic Review
  • Open Access
17 Citations
11,266 Views
30 Pages

Oral Complications Associated with the Piercing of Oral and Perioral Tissues and the Corresponding Degree of Awareness among Public and Professionals: A Systematic Review

  • Seyed Ali Mosaddad,
  • Sahar Talebi,
  • Maryam Hemmat,
  • Mohammadreza Karimi and ,
  • Alireza Jahangirnia,
  • Mostafa Alam,
  • Kamyar Abbasi,
  • Mohsn Yazadaniyan,
  • Ahmed Hussain and
  • Reza Abdollahi Namanloo
  • + 6 authors+ 1 author

2 November 2023

This study systematically reviews the literature to evaluate the potential relationships between oral/perioral piercing and consequent oral complications in the corresponding society. The second objective was determining public/professional sectors’...

(This article belongs to the Section Pathology and Molecular Diagnostics)
  • Systematic Review
  • Open Access
7 Citations
3,768 Views
17 Pages

Current Status and Future of Artificial Intelligence in MM Imaging: A Systematic Review

  • Ehsan Alipour,
  • Atefe Pooyan,
  • Firoozeh Shomal Zadeh,
  • Azad Duke Darbandi and ,
  • Pietro Andrea Bonaffini and
  • Majid Chalian
  • + 1 author+ 0 author

2 November 2023

Artificial intelligence (AI) has attracted increasing attention as a tool for the detection and management of several medical conditions. Multiple myeloma (MM), a malignancy characterized by uncontrolled proliferation of plasma cells, is one of the m...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Article
  • Open Access
1 Citations
5,339 Views
14 Pages

Percutaneous Computed Tomography-Guided Oxygen-Ozone (O2O3) Injection Therapy in Patients with Lower Back Pain—An Interventional Two-Year Follow-Up Study of 321 Patients

  • Kristina Davidovic,
  • Sebastian Cotofana,
  • Stephan Heisinger,
  • Slavica Savic and ,
  • Michael Alfertshofer,
  • Tatjana Antonić,
  • Sanja Jovanović,
  • Marko Ercegovac,
  • Mario Muto and
  • Ružica Maksimović
  • + 12 authors+ 7 authors

2 November 2023

Objectives: To assess the effect of oxygen-ozone therapy guided by percutaneous Computed Tomography (CT) compared to corticosteroids in individuals experiencing lower back pain (LBP) not attributed to underlying bone-related issues. Methods: A total...

(This article belongs to the Topic Paradigm Shift in Spinal Diseases: From Diagnosis to Therapy)
  • Article
  • Open Access
15 Citations
4,016 Views
18 Pages

Validation of Machine Learning Models for Craniofacial Growth Prediction

  • Eungyeong Kim,
  • Yasuhiro Kuroda,
  • Yoshiki Soeda,
  • So Koizumi and
  • Tetsutaro Yamaguchi

2 November 2023

This study identified the most accurate model for predicting longitudinal craniofacial growth in a Japanese population using statistical methods and machine learning. Longitudinal lateral cephalometric radiographs were collected from 59 children (27...

(This article belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)
  • Review
  • Open Access
6 Citations
4,881 Views
22 Pages

Unmasking Pandemic Echoes: An In-Depth Review of Long COVID’s Unabated Cardiovascular Consequences beyond 2020

  • Maria-Luiza Luchian,
  • Julien Higny,
  • Martin Benoit,
  • Benoit Robaye and ,
  • Yannick Berners,
  • Jean-Philippe Henry,
  • Benjamin Colle,
  • Olivier Xhaët,
  • Dominique Blommaert and
  • Fabian Demeure
  • + 10 authors+ 5 authors

2 November 2023

At the beginning of 2020, coronavirus disease 2019 (COVID-19) emerged as a new pandemic, leading to a worldwide health crisis and overwhelming healthcare systems due to high numbers of hospital admissions, insufficient resources, and a lack of standa...

(This article belongs to the Section Diagnostic Microbiology and Infectious Disease)
  • Article
  • Open Access
4 Citations
3,346 Views
15 Pages

Point-of-Care Testing to Differentiate Various Acid–Base Disorders in Chronic Kidney Disease

  • Tomasz Gołębiowski,
  • Sławomir Zmonarski,
  • Wiktoria Rożek,
  • Mateusz Powązka and ,
  • Patryk Jerzak,
  • Maciej Gołębiowski,
  • Mariusz Kusztal,
  • Piotr Olczyk,
  • Jakub Stojanowski and
  • Magdalena Krajewska
  • + 8 authors+ 3 authors

2 November 2023

Background: Normal-anion-gap metabolic acidosis (AGMA) and high-anion-gap metabolic acidosis (HAGMA) are two forms of metabolic acidosis, which is a common complication in patients with chronic kidney disease (CKD). The aim of this study is to identi...

(This article belongs to the Special Issue Recent Advances in Diagnosis and Treatment of Kidney Diseases)
  • Article
  • Open Access
5 Citations
5,982 Views
11 Pages

2 November 2023

The automated urine reagent strip test is a cost-effective tool for detecting albuminuria in patients. However, prior research has not investigated how urinary tract infections (UTIs) affect the test’s accuracy. Therefore, this study aims to as...

(This article belongs to the Special Issue Advances in the Diagnosis and Management of Kidney Diseases)
  • Article
  • Open Access
5 Citations
3,164 Views
10 Pages

Genetic Association Studies of MICB and PLCE1 with Severity of Dengue in Indonesian and Taiwanese Populations

  • Imaniar Noor Faridah,
  • Haafizah Dania,
  • Rita Maliza,
  • Wan-Hsuan Chou and ,
  • Wen-Hung Wang,
  • Yen-Hsu Chen,
  • Dyah Aryani Perwitasari and
  • Wei-Chiao Chang
  • + 3 authors+ 0 author

1 November 2023

Dengue is an arboviral disease that has spread globally and become a major public health concern. A small proportion of patients may progress from symptomatic dengue fever (DF) to dengue hemorrhagic fever (DHF) or dengue shock syndrome (DSS). Finding...

(This article belongs to the Special Issue Genomic Analysis of Infectious Diseases)
  • Article
  • Open Access
15 Citations
4,405 Views
20 Pages

Multi-Layer Preprocessing and U-Net with Residual Attention Block for Retinal Blood Vessel Segmentation

  • Ahmed Alsayat,
  • Mahmoud Elmezain,
  • Saad Alanazi,
  • Meshrif Alruily and ,
  • Ayman Mohamed Mostafa and
  • Wael Said
  • + 1 author+ 0 author

1 November 2023

Retinal blood vessel segmentation is a valuable tool for clinicians to diagnose conditions such as atherosclerosis, glaucoma, and age-related macular degeneration. This paper presents a new framework for segmenting blood vessels in retinal images. Th...

(This article belongs to the Special Issue Medical Data Processing and Analysis—2nd Edition)
  • Article
  • Open Access
14 Citations
3,775 Views
19 Pages

Automated Measurement of Vascular Calcification in Femoral Endarterectomy Patients Using Deep Learning

  • Alireza Bagheri Rajeoni,
  • Breanna Pederson,
  • Daniel G. Clair,
  • Susan M. Lessner and
  • Homayoun Valafar

1 November 2023

Atherosclerosis, a chronic inflammatory disease affecting the large arteries, presents a global health risk. Accurate analysis of diagnostic images, like computed tomographic angiograms (CTAs), is essential for staging and monitoring the progression...

(This article belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)
  • Review
  • Open Access
31 Citations
6,979 Views
13 Pages

Hyperglycaemia and Chronic Obstructive Pulmonary Disease

  • Mario Cazzola,
  • Paola Rogliani,
  • Josuel Ora,
  • Luigino Calzetta and ,
  • Davide Lauro and
  • Maria Gabriella Matera
  • + 1 author+ 0 author

1 November 2023

Chronic obstructive pulmonary disease (COPD) may coexist with type 2 diabetes mellitus (T2DM). Patients with COPD have an increased risk of developing T2DM compared with a control but, on the other side, hyperglycaemia and DM have been associated wit...

(This article belongs to the Special Issue Hyperglycemia in Respiratory Diseases—Impact and Challenges)
  • Article
  • Open Access
22 Citations
6,081 Views
15 Pages

Benign and Malignant Oral Lesion Image Classification Using Fine-Tuned Transfer Learning Techniques

  • Md. Monirul Islam,
  • K. M. Rafiqul Alam,
  • Jia Uddin,
  • Imran Ashraf and
  • Md Abdus Samad

1 November 2023

Oral lesions are a prevalent manifestation of oral disease, and the timely identification of oral lesions is imperative for effective intervention. Fortunately, deep learning algorithms have shown great potential for automated lesion detection. The p...

(This article belongs to the Special Issue Lesion Detection and Analysis Using Artificial Intelligence—2nd Edition)
  • Article
  • Open Access
6 Citations
4,146 Views
22 Pages

Fourteen Deaths from Suspected Heparin Overdose in an Italian Primary-Level Hospital

  • Nicola Di Fazio,
  • Matteo Scopetti,
  • Giuseppe Delogu,
  • Donato Morena and ,
  • Alessandro Santurro,
  • Luigi Cipolloni,
  • Gaetano Serviddio,
  • Luigi Papi,
  • Paola Frati and
  • Vittorio Fineschi
  • + 6 authors+ 1 author

1 November 2023

Healthcare-related homicidal cases are not novel within the medical–legal landscape, but investigations are often made difficult with the scarcity of material evidence related to the crime. For this reason, it is necessary to carefully analyze...

(This article belongs to the Section Pathology and Molecular Diagnostics)
  • Review
  • Open Access
23 Citations
9,651 Views
17 Pages

Lung Cancer Staging: Imaging and Potential Pitfalls

  • Lauren T. Erasmus,
  • Taylor A. Strange,
  • Rishi Agrawal,
  • Chad D. Strange and ,
  • Jitesh Ahuja,
  • Girish S. Shroff and
  • Mylene T. Truong
  • + 2 authors+ 0 author

1 November 2023

Lung cancer is the leading cause of cancer deaths in men and women in the United States. Accurate staging is needed to determine prognosis and devise effective treatment plans. The International Association for the Study of Lung Cancer (IASLC) has ma...

(This article belongs to the Special Issue Selected Topics in Thoracic Pathology)
  • Review
  • Open Access
21 Citations
6,989 Views
24 Pages

31 October 2023

Infectious keratitis (IK) is among the top five leading causes of blindness globally. Early diagnosis is needed to guide appropriate therapy to avoid complications such as vision impairment and blindness. Slit lamp microscopy and culture of corneal s...

(This article belongs to the Special Issue Diagnosis and Management of Eye Infections)
  • Review
  • Open Access
16 Citations
4,498 Views
15 Pages

Klotho in Cancer: Potential Diagnostic and Prognostic Applications

  • Jucileide Mota,
  • Alice Marques Moreira Lima,
  • Jhessica I. S. Gomes,
  • Marcelo Souza de Andrade and ,
  • Haissa O. Brito,
  • Melaine M. A. Lawall Silva,
  • Ana I. Faustino-Rocha,
  • Paula A. Oliveira,
  • Fernanda F. Lopes and
  • Rui M. Gil da Costa
  • + 5 authors+ 0 author

31 October 2023

Klotho proteins, αKlotho, βKlotho, and γKlotho, exert tumor-suppressive activities via the fibroblast growth factor receptors and multiple cell-signaling pathways. There is a growing interest in Klotho proteins as potential diagnosti...

(This article belongs to the Topic Prostate Cancer: Symptoms, Diagnosis & Treatment - 2nd Volume)
  • Article
  • Open Access
16 Citations
4,307 Views
14 Pages

Relationship between Abdominal Volume Index and Body Adiposity Index and Scales of Insulin Resistance and Metabolic Syndrome

  • José Ignacio Ramírez-Manent,
  • Ángel Arturo López-González,
  • Pilar Tomás-Gil,
  • Pere Riutord-Sbert and ,
  • Lucía Garrido-Sepulveda and
  • María Teofila Vicente-Herrero
  • + 1 author+ 0 author

31 October 2023

Introduction, objectives: Obesity is a global health problem with a great negative impact on health. Among the pathologies caused by obesity are insulin resistance and metabolic syndrome, which constitute an increasingly common health problem in both...

(This article belongs to the Section Pathology and Molecular Diagnostics)
  • Article
  • Open Access
21 Citations
3,127 Views
11 Pages

The Detection of Colorectal Cancer through Machine Learning-Based Breath Sensor Analysis

  • Inese Poļaka,
  • Linda Mežmale,
  • Linda Anarkulova,
  • Elīna Kononova and ,
  • Ilona Vilkoite,
  • Viktors Veliks,
  • Anna Marija Ļeščinska,
  • Ilmārs Stonāns,
  • Andrejs Pčolkins and
  • Mārcis Leja
  • + 11 authors+ 6 authors

31 October 2023

Colorectal cancer (CRC) is the third most common malignancy and the second most common cause of cancer-related deaths worldwide. While CRC screening is already part of organized programs in many countries, there remains a need for improved screening...

(This article belongs to the Special Issue Advances in the Diagnosis of Gastrointestinal Diseases—2nd Edition)
  • Article
  • Open Access
1 Citations
1,923 Views
13 Pages

Inverse Problem Algorithm-Based Time-Resolved Imaging of Head and Neck Computed Tomography Angiography Contrast Kinetics with Clinical Testification

  • Chih-Sheng Lin,
  • Bing-Ru Peng,
  • Hong-Bing Ma,
  • Ke-Lin Chen and ,
  • Tsung-Han Lin,
  • Lung-Kwang Pan and
  • Ya-Hui Lin
  • + 2 authors+ 0 author

31 October 2023

This study mitigated the challenge of head and neck CT angiography by IPA-based time-resolved imaging of contrast kinetics. To this end, 627 cerebral hemorrhage patients with dizziness, brain aneurysm, stroke, or hemorrhagic stroke diagnosis were ran...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Article
  • Open Access
12 Citations
4,907 Views
15 Pages

The Calculation and Evaluation of an Ultrasound-Estimated Fat Fraction in Non-Alcoholic Fatty Liver Disease and Metabolic-Associated Fatty Liver Disease

  • Pál Novák Kaposi,
  • Zita Zsombor,
  • Aladár D. Rónaszéki,
  • Bettina K. Budai and ,
  • Barbara Csongrády,
  • Róbert Stollmayer,
  • Ildikó Kalina,
  • Gabriella Győri,
  • Viktor Bérczi and
  • Krisztina Hagymási
  • + 8 authors+ 3 authors

31 October 2023

We aimed to develop a non-linear regression model that could predict the fat fraction of the liver (UEFF), similar to magnetic resonance imaging proton density fat fraction (MRI-PDFF), based on quantitative ultrasound (QUS) parameters. We measured an...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Article
  • Open Access
13 Citations
3,790 Views
14 Pages

Supervised Machine Learning Methods for Seasonal Influenza Diagnosis

  • Edna Marquez,
  • Eira Valeria Barrón-Palma,
  • Katya Rodríguez,
  • Jesus Savage and
  • Ana Laura Sanchez-Sandoval

31 October 2023

Influenza has been a stationary disease in Mexico since 2009, and this causes a high cost for the national public health system, including its detection using RT-qPCR tests, treatments, and absenteeism in the workplace. Despite influenza’s rele...

(This article belongs to the Special Issue Artificial Intelligence Advances for Medical Computer-Aided Diagnosis)
  • Article
  • Open Access
23 Citations
7,505 Views
14 Pages

Laparoscopic Adrenalectomy: Tailoring Approaches for the Optimal Resection of Adrenal Tumors

  • Ionela Mihai,
  • Adrian Boicean,
  • Cosmin Adrian Teodoru,
  • Nicolae Grigore and ,
  • Gabriela Mariana Iancu,
  • Horatiu Dura,
  • Dan Georgian Bratu,
  • Mihai Dan Roman,
  • Cosmin Ioan Mohor and
  • Adrian Hașegan
  • + 11 authors+ 6 authors

31 October 2023

In this study, we investigated the outcomes of laparoscopic approaches for adrenal tumor resection in 67 patients from a single center with a median age of 51 (range 40–79). Predominantly comprising women, the majority of patients were overweig...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Review
  • Open Access
69 Citations
17,436 Views
15 Pages

Biomarkers for Prostate Cancer: From Diagnosis to Treatment

  • Jia-Yan Chen,
  • Pei-Yan Wang,
  • Ming-Zhu Liu,
  • Feng Lyu and ,
  • Ming-Wei Ma,
  • Xue-Ying Ren and
  • Xian-Shu Gao
  • + 2 authors+ 0 author

31 October 2023

Prostate cancer (PCa) is a widespread malignancy with global significance, which substantially affects cancer-related mortality. Its spectrum varies widely, from slow-progressing cases to aggressive or even lethal forms. Effective patient stratificat...

(This article belongs to the Special Issue Advances in Diagnosis and Management of Prostate Cancer)
  • Article
  • Open Access
5 Citations
2,279 Views
15 Pages

Fractional Flow Reserve-Based Patient Risk Classification

  • Marijana Stanojević Pirković,
  • Ognjen Pavić,
  • Filip Filipović,
  • Igor Saveljić and ,
  • Tijana Geroski,
  • Themis Exarchos and
  • Nenad Filipović
  • + 2 authors+ 0 author

31 October 2023

Cardiovascular diseases (CVDs) are a leading cause of death. If not treated in a timely manner, cardiovascular diseases can cause a plethora of major life complications that can include disability and a loss of the ability to work. Globally, acute my...

(This article belongs to the Special Issue Artificial Intelligence in Clinical Medical Imaging)
  • Article
  • Open Access
12 Citations
3,178 Views
11 Pages

Galectin-3 as a Prognostic Biomarker in Patients with First Acute Myocardial Infarction without Heart Failure

  • Rada M. Vucic,
  • Olivera M. Andrejic,
  • Dragana Stokanovic,
  • Tatjana Jevtovic Stoimenov and ,
  • Lana McClements,
  • Valentina N. Nikolic,
  • Miodrag Sreckovic,
  • Mirjana Veselinovic,
  • Srdjan Aleksandric and
  • Milan Pavlovic
  • + 7 authors+ 2 authors

31 October 2023

Background: Galectin-3 (Gal-3) is a biomarker involved in a wide range of diseases including cardiac remodeling following acute myocardial infarction (AMI). Identification of prognostic markers in patients with AMI can guide strategies towards improv...

(This article belongs to the Special Issue Diagnosis, Prognosis, and Management of Cardiovascular Disease)
  • Article
  • Open Access
10 Citations
4,012 Views
12 Pages

Colorectal Endoscopic Submucosal Dissection: Performance of a Novel Hybrid-Technology Knife in an Animal Trial

  • Jérémie Jacques,
  • Horst Neuhaus,
  • Markus D. Enderle,
  • Ulrich Biber and ,
  • Walter Linzenbold,
  • Martin Schenk,
  • Kareem Khalaf and
  • Alessandro Repici
  • + 3 authors+ 0 author

30 October 2023

Endoscopic submucosal dissection (ESD) was developed for the removal of benign and early malignant lesions in the gastrointestinal tract. We aimed to evaluate the performance and safety of a novel high-pressure waterjet-assisted ESD knife in colorect...

(This article belongs to the Special Issue Endoscopy in Diagnosis of Gastrointestinal Disorders)
  • Article
  • Open Access
5 Citations
2,635 Views
12 Pages

Immunometabolic Profiling of Chronic Subdural Hematoma through Untargeted Mass Spectrometry Analysis: Preliminary Findings of a Novel Approach

  • Maria Kipele,
  • Michael Buchfelder,
  • R. Verena Taudte,
  • Andreas Stadlbauer and ,
  • Thomas Kinfe and
  • Yavor Bozhkov
  • + 1 author+ 0 author

30 October 2023

Objective: Metabolomics has growing importance in the research of inflammatory processes. Chronic subdural hematoma (cSDH) is considered to be, at least in part, of inflammatory nature, but no metabolic analyses yet exist. Therefore, a mass spectrome...

(This article belongs to the Special Issue Chronic Subdural Hematoma)
  • Article
  • Open Access
2,406 Views
11 Pages

Can Perfusion-Based Brain Tissue Oxygenation MRI Support the Understanding of Cerebral Abscesses In Vivo?

  • Michael Knott,
  • Philip Hoelter,
  • Liam Soder,
  • Sven Schlaffer and ,
  • Sophia Hoffmanns,
  • Roland Lang,
  • Arnd Doerfler and
  • Manuel Alexander Schmidt
  • + 3 authors+ 0 author

30 October 2023

Purpose: The clinical condition of a brain abscess is a potentially life-threatening disease. The combination of MRI-based imaging, surgical therapy and microbiological analysis is critical for the treatment and convalescence of the individual patien...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Article
  • Open Access
14 Citations
4,733 Views
22 Pages

Segmentation of Brain Tumor Using a 3D Generative Adversarial Network

  • Behnam Kiani Kalejahi,
  • Saeed Meshgini and
  • Sebelan Danishvar

30 October 2023

Images of brain tumors may only show up in a small subset of scans, so important details may be missed. Further, because labeling is typically a labor-intensive and time-consuming task, there are typically only a small number of medical imaging datas...

(This article belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

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Diagnostics - ISSN 2075-4418