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Volume 12
Issue 4
10.3390/diagnostics12040954
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Article

Rebleeding Rate and Risk Factors for Rebleeding after Device-Assisted Enteroscopy in Patients with Obscure Gastrointestinal Bleeding: A KASID Multicenter Study

by
Yuna Kim
1,†,
Jae-Hyun Kim
2,†,
Eun-Ae Kang
1,
Soo-Jung Park
1,
Jae-Jun Park
1,
Jae-Hee Cheon
1,
Tae-Il Kim
1,
Jihye Park
1,*,† and
Seong-Ran Jeon
3,*,†
1
Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul 03722, Korea
2
Division of Gastroenterology, Department of Internal Medicine, Kosin University College of Medicine, Busan 49267, Korea
3
Institute for Digestive Research, Digestive Disease Center, Soonchunhyang University College of Medicine, Seoul 04401, Korea
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Diagnostics 2022, 12(4), 954; https://doi.org/10.3390/diagnostics12040954
Submission received: 2 March 2022 / Revised: 1 April 2022 / Accepted: 10 April 2022 / Published: 11 April 2022
(This article belongs to the Special Issue Device-Assisted Enteroscopy: An Update on Diagnostic and Therapeutic Approaches)
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Abstract

Introduction: The impact of device-assisted enteroscopy (DAE) on long-term rebleeding in patients with obscure gastrointestinal bleeding (OGIB) exhibiting detectable small-bowel lesions remains unclear. We investigated the long-term rebleeding rate and predictive factors for DAE in patients with OGIB. Method: Patients with OGIB with small bowel lesions detected through DAE were enrolled at three Korean tertiary hospitals. Predictive risk factors associated with rebleeding were analyzed using the Cox regression analysis. Results: From April 2008 to April 2021, 141 patients were enrolled, including 38 patients (27.0%) with rebleeding. The rebleeding rates at 1, 2, and 3 years were 25.0%, 29.6%, and 31.1%, respectively. The Cox regression analysis revealed that multiple small-bowel lesions (hazard ratio [HR]: 2.551, 95% confidence interval [CI]: 1.157–5.627, p = 0.020), the need for more than five packed red blood cells (RBC) transfusions (HR: 2.704, 95% CI: 1.412–5.181, p = 0.003), and ulcerative lesions (HR: 1.992, 95% CI: 1.037–3.826, p = 0.039) were positively associated with rebleeding. Therapeutic interventions for patients with detectable lesions, overt bleeding (vs. occult bleeding), comorbidities, and medications were not associated with rebleeding. Conclusion: More than 25% of patients with OGIB having detectable small-bowel lesions had rebleeding. Patients with multiple lesions, a requirement of more than five packed RBC transfusions, and ulcerative lesions were associated with a higher risk of rebleeding.
Keywords: enteroscopy; obscure gastrointestinal bleeding; rebleeding; risk factor enteroscopy; obscure gastrointestinal bleeding; rebleeding; risk factor

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MDPI and ACS Style

Kim, Y.; Kim, J.-H.; Kang, E.-A.; Park, S.-J.; Park, J.-J.; Cheon, J.-H.; Kim, T.-I.; Park, J.; Jeon, S.-R. Rebleeding Rate and Risk Factors for Rebleeding after Device-Assisted Enteroscopy in Patients with Obscure Gastrointestinal Bleeding: A KASID Multicenter Study. Diagnostics 2022, 12, 954. https://doi.org/10.3390/diagnostics12040954

AMA Style

Kim Y, Kim J-H, Kang E-A, Park S-J, Park J-J, Cheon J-H, Kim T-I, Park J, Jeon S-R. Rebleeding Rate and Risk Factors for Rebleeding after Device-Assisted Enteroscopy in Patients with Obscure Gastrointestinal Bleeding: A KASID Multicenter Study. Diagnostics. 2022; 12(4):954. https://doi.org/10.3390/diagnostics12040954

Chicago/Turabian Style

Kim, Yuna, Jae-Hyun Kim, Eun-Ae Kang, Soo-Jung Park, Jae-Jun Park, Jae-Hee Cheon, Tae-Il Kim, Jihye Park, and Seong-Ran Jeon. 2022. "Rebleeding Rate and Risk Factors for Rebleeding after Device-Assisted Enteroscopy in Patients with Obscure Gastrointestinal Bleeding: A KASID Multicenter Study" Diagnostics 12, no. 4: 954. https://doi.org/10.3390/diagnostics12040954

APA Style

Kim, Y., Kim, J.-H., Kang, E.-A., Park, S.-J., Park, J.-J., Cheon, J.-H., Kim, T.-I., Park, J., & Jeon, S.-R. (2022). Rebleeding Rate and Risk Factors for Rebleeding after Device-Assisted Enteroscopy in Patients with Obscure Gastrointestinal Bleeding: A KASID Multicenter Study. Diagnostics, 12(4), 954. https://doi.org/10.3390/diagnostics12040954

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