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Clinical Impact of Combined Modified Glasgow Prognostic Score and C-Reactive Protein/Albumin Ratio in Patients with Colorectal Cancer

1
Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul 06273, Korea
2
Department of Pathology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul 06273, Korea
3
Department of Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, Korea
*
Author to whom correspondence should be addressed.
Diagnostics 2020, 10(11), 859; https://doi.org/10.3390/diagnostics10110859
Received: 30 September 2020 / Revised: 19 October 2020 / Accepted: 20 October 2020 / Published: 22 October 2020
(This article belongs to the Section Pathology and Molecular Diagnostics)
The prognostic impact of the combination of the modified Glasgow prognostic score (mGPS) and C-reactive protein/albumin ratio (CAR) in colorectal cancer (CRC) is unclear. We aimed to investigate the clinical usefulness of this combination as a predictor of survival in CRC patients. We retrospectively evaluated 769 CRC patients who had undergone surgery between January 2006 and March 2014. The CAR and mGPS within 1 month postoperation were examined. The integrated area under the curve (iAUC) was compared among mGPS, CAR, and the combined classification (CC). The optimal CAR cut-off for discriminating overall survival was 0.14. Based on this cut-off, the mGPS 0 group was divided into the mGPS 0 with low CAR and the mGPS 0 with high CAR groups, whereas all mGPS 1 and 2 patients were classified into the high CAR group. CC was an independent prognostic factor, and its iAUC value (0.587, 95% CI 0.553–0.624) was superior to those of the mGPS (0.544, 95% CI 0.516–0.576) (bootstrap iAUC mean difference = 0.043; 95% CI = 0.015–0.072) and CAR (0.578, 95% CI 0.545–0.613) (bootstrap iAUC mean difference = 0.009; 95% CI = 0.002–0.017), respectively. In conclusion, the combination of mGPS and CAR has a synergistic effect and has a higher prognostic accuracy than mGPS or CAR alone in patients with CRC. View Full-Text
Keywords: modified glasgow prognostic score; C-reactive protein/albumin ratio; colorectal cancer; survival; integrated area under the curve modified glasgow prognostic score; C-reactive protein/albumin ratio; colorectal cancer; survival; integrated area under the curve
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MDPI and ACS Style

Son, W.; Shin, S.-J.; Park, S.H.; Lee, S.K.; Park, E.J.; Baik, S.H.; Lee, K.Y.; Kang, J. Clinical Impact of Combined Modified Glasgow Prognostic Score and C-Reactive Protein/Albumin Ratio in Patients with Colorectal Cancer. Diagnostics 2020, 10, 859. https://doi.org/10.3390/diagnostics10110859

AMA Style

Son W, Shin S-J, Park SH, Lee SK, Park EJ, Baik SH, Lee KY, Kang J. Clinical Impact of Combined Modified Glasgow Prognostic Score and C-Reactive Protein/Albumin Ratio in Patients with Colorectal Cancer. Diagnostics. 2020; 10(11):859. https://doi.org/10.3390/diagnostics10110859

Chicago/Turabian Style

Son, Woosung, Su-Jin Shin, Su H. Park, Soo K. Lee, Eun J. Park, Seung H. Baik, Kang Y. Lee, and Jeonghyun Kang. 2020. "Clinical Impact of Combined Modified Glasgow Prognostic Score and C-Reactive Protein/Albumin Ratio in Patients with Colorectal Cancer" Diagnostics 10, no. 11: 859. https://doi.org/10.3390/diagnostics10110859

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