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Life, Volume 14, Issue 8

August 2024 - 136 articles

Cover Story: Oncologic back pain, infection, inflammation, and trauma are the only specific etiologies of chronic low back pain (CLBP) in contrast to most patients who have non-specific CLBP. In the case of symptomatic SM, we can distinguish three main categories: tumor pain; mechanical pain due to instability, with or without pathologic fractures; and metastatic epidural spinal cord compression (MESCC) or radicular compression. Treatment of SM-related pain is dependent on these categories and consists of symptomatic treatment, target therapy to the bone, radiotherapy, systemic oncologic treatment, and surgery. In this review, we explore the pathophysiology and symptomatology of SM and the treatment options for SM-related pain: tumor pain; mechanical pain due to instability, with or without pathologic fractures; and MESCC or radicular compression. View this paper
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Articles (136)

  • Article
  • Open Access
1 Citations
1,546 Views
14 Pages

19 August 2024

Understanding the genetic basis of salt resistance in crops is crucial for agricultural productivity. This study investigates the phenotypic and genetic basis of salt stress response in rice (Oryza sativa L.), focusing on germination and seedling tra...

  • Article
  • Open Access
1 Citations
2,131 Views
15 Pages

19 August 2024

Ischemia/reperfusion (I/R) is inevitable during kidney transplantation and causes acute kidney injury (AKI), which affects immediate outcome and leads to chronic changes such as fibrotic remodeling of the graft. We investigated pro-fibrotic signaling...

  • Article
  • Open Access
1,388 Views
13 Pages

Clinical Characterization of Pathogens, Risk Factors and Quality of Life in an Observational Study of Native vs. Prosthetic Aortic Valve Endocarditis Surgery

  • Anton Heller,
  • Matthäus Zerdzitzki,
  • Philipp Hegner,
  • Zhiyang Song,
  • Christian Schach,
  • Florian Hitzenbichler,
  • Kostiantyn Kozakov,
  • Claudius Thiedemann,
  • Zdenek Provaznik and
  • Christof Schmid
  • + 1 author

19 August 2024

Background: Native (NVE) and prosthetic (PVE) aortic valve endocarditis (AVE) remain a surgical challenge with an ongoing trend towards more complex surgical procedures. Methods: First-time NVE was compared with PVE, focusing on pathogens, risk facto...

  • Article
  • Open Access
1,769 Views
15 Pages

Extreme Body Condition Index Values in Small Mammals

  • Linas Balčiauskas and
  • Laima Balčiauskienė

19 August 2024

The body condition index (BCI) values in small mammals are important in understanding their survival and reproduction. The upper values could be related to the Chitty effect (presence of very heavy individuals), while the minimum ones are little know...

  • Article
  • Open Access
1 Citations
2,183 Views
13 Pages

Revisiting the COVID-19 Pandemic: Mortality and Predictors of Death in Adult Patients in the Intensive Care Unit

  • Adriana Lemos de Sousa Neto,
  • Clesnan Mendes-Rodrigues,
  • Reginaldo dos Santos Pedroso and
  • Denise Von Dolinger de Brito Röder

19 August 2024

COVID-19 has generated a global impact due to its contagiousness and high lethality rates, with a large number of deaths occurring in intensive care units (ICUs). This study aimed to verify the occurrence of and understand the factors related to mort...

  • Article
  • Open Access
1,737 Views
12 Pages

The Association of Depression with Obstructive Sleep Apnea in Patients with Cystic and Non-Cystic Fibrosis Bronchiectasis

  • Baran Balcan,
  • Duygu Vezir,
  • Sehnaz Olgun Yildizeli,
  • Derya Kocakaya and
  • Berrin Ceyhan

19 August 2024

Obstructive sleep apnea (OSA) and cystic fibrosis (CF) are chronic conditions that profoundly impact quality of life. OSA, characterized by repeated episodes of upper airway collapse, can exacerbate CF symptoms due to nocturnal airway obstruction. Re...

  • Article
  • Open Access
1 Citations
2,154 Views
14 Pages

Exploring Therapeutic Challenges in Patients with HER2-Positive Breast Cancer—A Single-Center Experience

  • Ramona Coca,
  • Andrei Moisin,
  • Rafaela Coca,
  • Atasie Diter,
  • Mihaela Racheriu,
  • Denisa Tanasescu,
  • Carmen Popa,
  • Maria-Emilia Cerghedean-Florea,
  • Adrian Boicean and
  • Ciprian Tanasescu

18 August 2024

Breast cancer is one of the most common forms of neoplasia worldwide. The purpose of our observational study was to evaluate the status of HER2 overexpression among new cases of breast neoplasia with an impact on the natural history of breast cancer...

  • Brief Report
  • Open Access
4 Citations
2,296 Views
13 Pages

Methylated DNA Markers in Voided Urine for the Identification of Clinically Significant Prostate Cancer

  • Paras Shah,
  • William R. Taylor,
  • Brianna J. Negaard,
  • Benjamin R. Gochanour,
  • Douglas W. Mahoney,
  • Sara S. Then,
  • Mary E. Devens,
  • Patrick H. Foote,
  • Karen A. Doering and
  • Kelli N. Burger
  • + 6 authors

18 August 2024

Introduction: Non-invasive assays are needed to better discriminate patients with prostate cancer (PCa) to avoid over-treatment of indolent disease. We analyzed 14 methylated DNA markers (MDMs) from urine samples of patients with biopsy-proven PCa re...

  • Article
  • Open Access
1 Citations
2,152 Views
10 Pages

Antiviral Efficacy of Coridothymus capitatus Essential Oil Against HSV-1 and HSV-2

  • Virginia Fuochi,
  • Pio Maria Furneri,
  • Salvatore Furnari and
  • Adriana Garozzo

18 August 2024

Coridothymus capitatus is a perennial herb with aromatic leaves and flowers, distinct from Thymus vulgaris in its chemical composition, resulting in a unique Thymus Essential Oil (TEO). A main component of TEO, carvacrol, is known for its antimicrobi...

  • Article
  • Open Access
9 Citations
2,445 Views
13 Pages

Can Gentisic Acid Serve as a High-Performance Antioxidant with Lower Toxicity for a Promising New Topical Application?

  • Luciano B. Cunha,
  • Eloah D. Lepore,
  • Camila Cristina B. Medeiros,
  • Rodrigo Sorrechia,
  • Rosemeire C. L. R. Pietro and
  • Marcos A. Corrêa

17 August 2024

Gentisic acid (2,5-dihydroxybenzoic acid) is primarily found naturally in plants and has demonstrated a significant range of biological activities; however, its efficacy and safety as a topical application ingredient are not yet well established. Thu...

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Life - ISSN 2075-1729