Submit to Special Issue Submit Abstract to Special Issue Review for Life Edit a Special Issue

Journal Browser

► Journal Browser

Special Issue "Current Research on Dermatology: Pathology, Clinical Manifestation, Investigation and Therapy"

Print Special Issue Flyer
Special Issue Editors
Special Issue Information
Keywords
Published Papers

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".

Deadline for manuscript submissions: 25 August 2023 | Viewed by 15763

Share This Special Issue

Special Issue Editor

Prof. Dr. Alin Laurentiu Tatu

E-Mail Website1 Website2
Guest Editor

1. Clinical Department, Dermatology, Faculty of Medicine and Pharmacy, Dunarea de Jos University, Galati, Romania
2. Saint Parascheva Clinical Hospital of Infectious Diseases, Head of the Dermatology Department, Galati, Romania
3. Multidisciplinary Integrated Center of Dermatological Interface Research (MICDIR), Galati, Romania
Interests: demodex; endosymbionts; cutaneous microbiome; integrative medicine; optical coherence tomography; dermoscopy; confocal microscopy ; cutaneous comorbidities; skin cancer
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Considering recent advances in the field, dermatovenerology has proven to be a specialty of clinical, investigative, and therapeutic interest. Medical history and clinical examination, followed by non-invasive imaging or blood tests or the exploration of skin structures and their pathological changes, allow pathologists to better understand, detect, and define diseases of the skin. Cutaneous signs and symptoms thus represent a window into the systemic state of the human body. Many diseases thought to be localized to the skin are now considered to be systemically involved in other areas. Each patient is unique, with their own comorbidities and anatomic or physiologic particularities. Cutaneous skin diseases vary in appearance, evolution, and prognosis as well as in their response to various treatments. The management of skin disease comorbidities requires interdisciplinary collaboration among medical and surgical specialties. Novel treatments are now available for various skin conditions, including surgical, cosmetic, and physiotherapeutic procedures. Drugs of both plant and chemical origin can produce systemic or adverse skin reactions. If classical therapy is ineffective or is not tolerated, off-the-label drugs or complementary and alternative medicine methods can be used as part of an integrative medicine treatment. The new perspectives offered by translational medicine and research on the microbiome, endosymbionts, inflammatory molecules, diagnostics, treatments, and observations of comorbidities, complications, and their management are improving the standard of skin care, placing it in the context of personalized medicine and care. This Special Issue of Life, entitled “Current Research on Dermatology: Pathology, Clinical Manifestation, Investigation and Therapy ”, will collect and present data on the latest developments in the field. We welcome reviews, research/original articles, case reports, and short review, clinical dermatology images (max: 175 words, 10 references, and 4 images). Articles should comprise roughly 3000 words and include more than 30 references. Review papers should be around 4000 words and include at least two figures or tables. Life has no restrictions on the maximum length of research manuscripts, provided that the text is concise and comprehensive. Papers may have two correspondent authors and two first authors. Submissions received before 24 June 2022 may receive a 20% discount.

Prof. Dr. Alin Laurentiu Tatu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

demodex
endosymbionts
cutaneous microbiome
optical coherence tomography
dermoscopy
confocal microscopy
cutaneous comorbidities keyword
inflammatory diseases
hair
skin cancer
comorbidities
skin surgery

Published Papers (15 papers)

Download All Papers

Research

Jump to: Review, Other

Open AccessArticle

Niosomal Curcumin Suppresses IL17/IL23 Immunopathogenic Axis in Skin Lesions of Psoriatic Patients: A Pilot Randomized Controlled Trial

Hanieh Kolahdooz

Vahid Khori

Vahid Erfani-Moghadam

Fatemeh Livani

Saeed Mohammadi

and

Ali Memarian

Life 2023, 13(5), 1076; https://doi.org/10.3390/life13051076 - 24 Apr 2023

Viewed by 545

Abstract

Psoriasis (PS) is characterized by hyperplasia of epidermis and infiltration of immune cells in the dermis. A negligible susceptibility of hypodermic permeation for local anti-inflammatory remedies is one of the major causes of medication failures. Although curcumin (CUR) has indicated effectiveness in treatment of inflammation, its successful permeation through the stratum corneum is yet a challenging issue. Therefore, niosome (NIO) nanoparticles were used as curcumin carriers to enhance its delivery and anti-inflammatory effects. Curcumin-niosome (CUR-NIO) formulations were constructed by the thin-film-hydration (TFH) technique and were added to hyaluronic acid and Marine-collagen gel-based formulation. Five mild-to-moderate PS patients (18–60 years) with PASI scores < 30 with symmetrical and similar lesions were included in the study. The prepared formulation (CUR 15 µM) was topically administered for 4 weeks on the skin lesions, in comparison to the placebo. Clinical skin manifestations were monitored and skin punches were obtained for further gene expression analyses. There was a significant reduction in redness, scaling, and an apparent improvement in CUR-NIO-treated group in comparison to the placebo-treated counterpart. The gene expression analyses resulted in significantly downregulation of IL17, IL23, IL22, and TNFα, S100A7, S100A12, and Ki67 in CUR-NIO-treated lesions. Consequently, CUR-NIO could provide therapeutic approaches for the patients with mild-to-moderate PS by suppressing the IL17/IL23 immunopathogenic axis. Full article

(This article belongs to the Special Issue Current Research on Dermatology: Pathology, Clinical Manifestation, Investigation and Therapy)

► Show Figures

Figure 1

Open AccessArticle

Basal Cell Carcinoma—A Retrospective Descriptive Study Integrated in Current Literature

Nicoleta Amalia Dobrete

and

Silviu Adrian Marinescu

Life 2023, 13(3), 832; https://doi.org/10.3390/life13030832 - 19 Mar 2023

Viewed by 642

Abstract

Basal cell carcinoma (BCC) is considered to be the most common cancer in humans. It has a slow growth rhythm, and for this reason, metastases are rare. For our retrospective study, we selected 180 patients from those who underwent surgery for a variety of skin tumours between January 2019 and August 2022 and whose histopathological examination revealed basal cell carcinoma. All surgeries were performed by plastic surgeons at the “St. John” hospital in Bucharest. The aim of this article is to provide observational data regarding BCC—in terms of histopathology and diagnostic and therapeutic management and to integrate these data into the current knowledge of this pathology. Full article

(This article belongs to the Special Issue Current Research on Dermatology: Pathology, Clinical Manifestation, Investigation and Therapy)

► Show Figures

Figure 1

Open AccessArticle

Principles of Treatment and Clinical-Evolutionary Peculiarities of Deep Cervical Spaces Suppurations—Clinical Study

Daniela Jicman (Stan)

Nicolae Sârbu

Laura-Florentina Rebegea

Alin Codruț Nicolescu

and

Alin Laurențiu Tatu

Life 2023, 13(2), 535; https://doi.org/10.3390/life13020535 - 15 Feb 2023

Viewed by 1052

Abstract

As medical-surgical emergencies, regardless of the causal agent, deep cervical space suppurations are not only a diagnostic challenge, but also a therapeutic one. In some cases, in spite of proper therapeutic measures, extremely severe complications can develop. A 5-year retrospective study (2016–2020) was conducted on a group of 107 patients suffering from cervical suppurations, being hospitalized and treated in the ENT Clinic of the “Sf. Apostol Andrei” Emergency County Hospital of Galați. This research is a clinical-statistical study based on the experience of this ENT clinic and was carried out based on the analysis of the patients’ medical records. Descriptive analysis’ statistical methods of the data series collected from the clinical observation sheets were used, with the patients’ informed consent for the processing of the aforementioned data, with the agreement of the Ethics Commission of the Emergency Clinical Hospital “Sf. Apostol Andrei” Galați and the College of Physicians Galați, România. The patients’ clinical and multidisciplinary treatment features included in the study group are presented. The results highlight the clinical particularities of deep cervical space suppurations treatment, including under COVID-19 impact, or with other comorbidities, having consequences on the case mix index increase or directly on the costs, admittance duration and the clinical status of the patient at discharge. The conclusions of the clinical study are based on the fulfillment of the research objectives in terms of treatment and symptomatology of deep cervical space suppurations and under the impact of comorbidities (global health crisis and pandemic, triggering of comorbidities due to health care access difficulty in the context of anti-COVID-19 government-implemented measures and the infection-rate that overburdened the medical system in the early period of the pandemic). Individualized treatment of deep cervical space suppurations is recommended to be approached multidisciplinary. Of particular importance is early diagnosis combined with prompt and correctly instituted multidisciplinary treatment. In this context, an appropriate medical measure that we recommend is patient health education, as it was observed in the clinical study: most times, patients address medical services with advanced disease, hence the generally unfavorable prognosis and outcome (about 25% of patients develop unfavorable prognosis and 4% die). Full article

(This article belongs to the Special Issue Current Research on Dermatology: Pathology, Clinical Manifestation, Investigation and Therapy)

► Show Figures

Figure 1

Open AccessArticle

The Many Roles of Dermoscopy in Melanoma Detection

Cristina-Raluca (Jitian) Mihulecea

Gabriela Mariana Iancu

Mihaela Leventer

and

Maria Rotaru

Life 2023, 13(2), 477; https://doi.org/10.3390/life13020477 - 09 Feb 2023

Viewed by 1052

Abstract

Dermoscopy is a non-invasive method of examination that aids the clinician in many ways, especially in early skin cancer detection. Melanoma is one of the most aggressive forms of skin cancer that can affect individuals of any age, having an increasing incidence worldwide. The gold standard for melanoma diagnosis is histopathological examination, but dermoscopy is also very important for its detection. To highlight the many roles of dermoscopy, we analyzed 200 melanocytic lesions. The main objective of this study was to detect through dermoscopy hints of melanomagenesis in the studied lot. The most suspicious were 10 lesions which proved to be melanomas confirmed through histopathology. The second objective of this study was to establish if dermoscopy can aid in estimating the Breslow index (tumoral thickness) of the melanomas and to compare the results to the histopathological examination. We found that the tumoral thickness may be estimated through dermoscopy, but the histopathological examination is superior. To conclude, the aim of this study was to showcase the versatility and many roles of dermoscopy, besides being one of the most important tools for early melanoma diagnosis. Full article

(This article belongs to the Special Issue Current Research on Dermatology: Pathology, Clinical Manifestation, Investigation and Therapy)

► Show Figures

Figure 1

Open AccessArticle

Pharyngeal-Esophageal Malignancies with Dermatologic Paraneoplastic Syndrome

Ana Fulga

Doriana Cristea Ene

Laura Bujoreanu Bezman

and

Life 2022, 12(11), 1705; https://doi.org/10.3390/life12111705 - 26 Oct 2022

Viewed by 1294

Abstract

Systemic changes often send signals to the skin, and certain neoplastic diseases of the internal organs can also trigger skin manifestations. In this article, the authors make clinical photography presentations of the patients seen at our clinic with dermatologic paraneoplastic syndromes within pharyngeal–esophageal malignancies, describe several paraneoplastic dermatoses, and also review high-quality scientific literature in order to be able to highlight the dermatological signs of pharyngoesophageal malignant tumors. The majority of our patients with paraneoplastic dermatoses, filtering for pharyngoesophageal malignancies, had esophageal neoplasms, out of whom seven were female and two were male, making esophageal cancer more common within the paraneoplastic dermatoses within pharyngoesophageal malignancies. An early recognition of paraneoplastic dermatoses can diagnose neoplasms and sequentially contribute to a better prognosis for the patient. This matter is also useful for front-line medical personnel in order to improve early diagnosis of the underlying malignancy, curative interventions with prompt therapy administration and good prognosis. Full article

(This article belongs to the Special Issue Current Research on Dermatology: Pathology, Clinical Manifestation, Investigation and Therapy)

► Show Figures

Figure 1

Review

Jump to: Research, Other

Open AccessReview

Annular Erythemas and Purpuras

Nicolas Kluger

Life 2023, 13(6), 1245; https://doi.org/10.3390/life13061245 - 24 May 2023

Viewed by 210

Abstract

Annular dermatoses are a heterogeneous and extremely diverse group of skin diseases, which share in common annular, ring-like patterns with centrifugal spreading. Numerous skin diseases can sometimes display annular lesions, but some specific skin conditions are originally annular. We take the opportunity to [...] Read more.

(This article belongs to the Special Issue Current Research on Dermatology: Pathology, Clinical Manifestation, Investigation and Therapy)

► Show Figures

Figure 1

Open AccessReview

Sweet Syndrome Associated with Myelodysplastic Syndrome—A Review of a Multidisciplinary Approach

Cătălina Roxana Ferea

Stejara Nicoleta Mihai

Gabriela Balan

Minerva Codruta Badescu

Dana Tutunaru

and

Alin Laurențiu Tatu

Life 2023, 13(3), 809; https://doi.org/10.3390/life13030809 - 16 Mar 2023

Viewed by 729

Abstract

Sweet syndrome (SS) is a rare disease described as a febrile neutrophilic dermatosis with acute onset, the pathogenesis of which has not yet been elucidated. The syndrome is characterized by the sudden onset of erythematous infiltrated papules or plaques located on the upper body and is associated with fever, leukocytosis and neutrophilia. The lesions show a dense dermal infiltration with mature neutrophils. The condition is responsive to systemic steroids. The central nervous system, bones, muscles, eyes, ears, mouth, heart, lung, liver, kidneys, intestines, and spleen may be affected by SS as extracutaneous manifestations. More and more cases have been found to be associated with malignancies, particularly myelodysplastic syndrome, and, less frequently, other hematologic malignancies or solid tumors. Approximately 21% of patients with SS have an associated malignancy and up to 80% of MASS cases are associated with hematological diseases, predominantly myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML). Myelodysplastic syndrome is a clonal disease of the bone marrow characterized by inefficient hematopoiesis, dysplasia of the bone marrow and peripheral cytopenias. Affected patients have a high risk of leukemic transformation. After analyzing later studies and current practical aspects regarding MDS-related SS, we suggest an algorithm for evaluating these patients. Full article

(This article belongs to the Special Issue Current Research on Dermatology: Pathology, Clinical Manifestation, Investigation and Therapy)

► Show Figures

Figure 1

Open AccessReview

Review: The Key Factors to Melanomagenesis

Cristina-Raluca (Jitian) Mihulecea

and

Maria Rotaru

Life 2023, 13(1), 181; https://doi.org/10.3390/life13010181 - 08 Jan 2023

Viewed by 860

Abstract

Melanoma is the most dangerous form of skin cancer that develops from the malignant transformation of the melanocytes located in the basal layer of the epidermis (cutaneous melanoma). Melanocytes may also be found in the meninges, eyes, ears, gastrointestinal tract, genito-urinary system, or other mucosal surfaces (mucosal melanoma). Melanoma is caused by an uncontrolled proliferation of melanocytes, that at first may form a benign lesion (nevogenesis), but in time, it may transition to melanoma, determining what it is named, melanomagenesis. Some tumors may appear spontaneously (de novo melanoma) or on preexisting lesions (nevus-associated melanoma). The exact cause of melanoma may not be fully understood yet, but there are some factors that initiate and promote this malignant process. This study aims to provide a summary of the latest articles regarding the key factors that may lead to melanomagenesis. The secondary objectives are to reveal the relationship between nevi and melanoma, to understand the cause of “de novo” and “nevus-associated melanoma” and highlight the differences between these subtypes. Full article

(This article belongs to the Special Issue Current Research on Dermatology: Pathology, Clinical Manifestation, Investigation and Therapy)

Open AccessReview

Psoriasis Management Challenges Regarding Difficult-to-Treat Areas: Therapeutic Decision and Effectiveness

Alin Codrut Nicolescu

Marius-Anton Ionescu

Maria Magdalena Constantin

and

Life 2022, 12(12), 2050; https://doi.org/10.3390/life12122050 - 07 Dec 2022

Cited by 2 | Viewed by 1546

Abstract

Psoriasis is not optimally controlled in spite of newly developed treatments, possibly due to the difficulty of objectively quantifying the disease’s severity, considering the limitations of the clinical scores used in clinical practice. A major challenge addresses difficult-to-treat areas, especially in the absence of significant body surface involvement. It is controversial whether the severity evaluation of patients with several affected areas (having at least one difficult-to-treat area) should be done differently from current methods. Scores used for special areas (PSSI, NAPSI and ESIF) allow an accurate assessment of disease severity in difficult-to-treat areas, but the issue of whether to integrate these scores into PASI, BSA or DLQI remains. The review’s purpose resides in providing an overview of the main current issues in determining psoriasis severity in patients with psoriasis in difficult-to-treat areas and suggesting possible solutions for the optimal integration of the area assessment in current scores: severity can be either established according to the highest calculated score (PASI or PSSI or NAPSI or ESIF) or by adding a correction factor in the calculation of PASI for special areas. Full article

(This article belongs to the Special Issue Current Research on Dermatology: Pathology, Clinical Manifestation, Investigation and Therapy)

► Show Figures

Figure 1

Other

Jump to: Research, Review

Open AccessBrief Report

Immunohistochemical Analysis of Adhesion Molecules E-Selectin, Intercellular Adhesion Molecule-1, and Vascular Cell Adhesion Molecule-1 in Inflammatory Lesions of Atopic Dermatitis

Sandra Marinović Kulišić

Marta Takahashi

Marta Himelreich Perić

Vedrana Mužić Radović

and

Ružica Jurakić Tončić

Life 2023, 13(4), 933; https://doi.org/10.3390/life13040933 - 02 Apr 2023

Viewed by 581

Abstract

E-selectin, ICAM-1 (intercellular adhesion molecule-1), and VCAM-1 (vascular cell adhesion molecule-1) play a role in atopic dermatitis (AD). This study aimed to evaluate their expression in skin biopsy specimens of patients diagnosed with AD using an optimized computer program. A descriptive analysis and comparison of digitally measured surface area and cell number were performed. The number of E-selectin-positive cells did not vary between the groups. In patients with AD, decreases of 1.2-fold for ICAM-1- and 1.3-fold for VCAM-1- positive cells were observed. The E-selectin-positive epidermal surface area increased (p < 0.001), while ICAM1 and VCAM1 decreased 2.5-fold and 2-fold, respectively, compared to controls. In the AD-affected skin, the E-selectin-positive endothelial area was 3.5-fold larger (p < 0.001), and the ICAM1-positive area was almost 4-fold larger (p < 0.001). E-selectin and ICAM-1 were expressed in the control dermis moderately and weakly, respectively. A strong E-selectin signal was detected in the AD-affected skin macrophages and a strong ICAM-1 signal in the dermal vessel endothelium. In the endothelial cells of AD-affected skin, no VCAM-1 signal could be found. E-selectin, ICAM-1, and VCAM-1 expression show significant disease-specific changes between AD-affected and control skin. The combination of digital analysis and a pathologist’s evaluation may present a valuable follow-up of AD activity parameters. Full article

(This article belongs to the Special Issue Current Research on Dermatology: Pathology, Clinical Manifestation, Investigation and Therapy)

► Show Figures

Figure 1

Open AccessCase Report

Ulceration and a White Lesion of the Tongue in a Male HIV Positive Patient: A Journey on the Avenue of Differential Diagnoses in Search of a Solution

Manuela Arbune

Monica-Daniela Padurariu-Covit

and

Life 2023, 13(4), 901; https://doi.org/10.3390/life13040901 - 28 Mar 2023

Viewed by 883

Abstract

Oral lesions are early indicator of immunosuppression, leading to HIV new diagnoses. The type of oral lesions can reveal opportunistic diseases that are correlated with the severity of immune depletion. Highly active antiretroviral therapy decreases the incidence of opportunistic oral infections, whereas a large variety of lesions are frequently experienced in people with HIV. Overlapping pathogenic mechanisms and multiple contributing etiologies are related to unusual, atypical oral lesions that are challenging in the clinical practice. We present a rare case of eosinophilic granuloma of the tongue in an older male HIV patient with severe immunosuppression due to the failure of antiretroviral treatment. Differential diagnoses considered squamous carcinoma, lymphoma, viral, fungal or bacterial infections and autoimmune disorders, as well as the influence of HIV immune disfunctions or the influence of cannabidiol use. The histopathologic and immunohistochemistry examination clarified the inflammatory reactive benign substrate of the lesion, although future survey of the oral lesions is essential. Full article

(This article belongs to the Special Issue Current Research on Dermatology: Pathology, Clinical Manifestation, Investigation and Therapy)

► Show Figures

Figure 1

Open AccessSystematic Review

Erosive Pustular Dermatosis: Delving into Etiopathogenesis and Management

and

Life 2022, 12(12), 2097; https://doi.org/10.3390/life12122097 - 13 Dec 2022

Viewed by 866

Abstract

Erosive pustular dermatosis (EPD) is a chronic inflammatory skin disorder that usually affects mature individuals. It predominantly affects the scalp and can lead to scarring alopecia. Risk factors include actinic damage and androgenetic alopecia. A traumatic insult to the skin is considered a vital trigger of the condition. EPD is a diagnosis of exclusion; thus, several neoplastic, infectious, vesiculobullous, and inflammatory conditions should be ruled out. Biopsy and clinicopathologic correlation are required to differentiate between EPD and these entities. A dysregulated, chronic immune response is considered central to the etiopathogenesis of EPD. We performed an evidence-based systematic review of the management options. There were predominantly studies with level IV and V evidence and only two with level III. Despite the responsiveness of EPD to potent topical steroids, such as clobetasol propionate, recurrence occurs after treatment withdrawal. With the available data, tacrolimus 0.1%, curettage-assisted aminolevulinic acid-photodynamic therapy, and systemic retinoids can be considered second-line options for EPD with a role in maintenance regimens. However, controlled data and more powerful studies are needed to make solid recommendations. Full article

(This article belongs to the Special Issue Current Research on Dermatology: Pathology, Clinical Manifestation, Investigation and Therapy)

► Show Figures

Figure 1

Open AccessCase Report

Primary Cutaneous B-Cell Lymphoma Co-Existing with Mycosis Fungoides—A Case Report and Overview of the Literature

Doriana Sorina Chilom

Simona Sorina Farcaș

and

Nicoleta Ioana Andreescu

Life 2022, 12(12), 2067; https://doi.org/10.3390/life12122067 - 09 Dec 2022

Viewed by 1564

Abstract

The existence of two sequential lymphomas, one localized and one systemic, either both with B or T lymphocytes, or one with B cells and one with T cells, with the same patient, is a known possibility. The second lymphoma is often induced by immunodepression or by the initial treatment. However, the existence of two cutaneous lymphomas with different cell lines, without systemic involvement, represents an uncommon situation. In this report, we describe the case of a 37-year-old man with an initial diagnosis of PMZBCL that over 10 months also developed a MF patch/plaque on the left leg. Full article

(This article belongs to the Special Issue Current Research on Dermatology: Pathology, Clinical Manifestation, Investigation and Therapy)

► Show Figures

Figure 1

Open AccessCase Report

Treatment of Severe Atopic Dermatitis with Dupilumab in Three Patients with Renal Diseases

and

Biagina Gisella Mennuni

Life 2022, 12(12), 2002; https://doi.org/10.3390/life12122002 - 30 Nov 2022

Cited by 1 | Viewed by 1241

Abstract

Background: Atopic dermatitis (AD) is a chronic relapsing inflammatory skin disease that can affect patients’ quality of life. Dupilumab is the first biologic agent approved for the treatment of patients with inadequately controlled moderate-to-severe AD and its mechanism of action is based on the inhibition of the interleukin (IL)-4 and IL-13 signaling. There are only a few data on the safety of dupilumab in AD patients with comorbidities, including kidney disorders. Materials and Methods: Descriptive retrospective series of three patients with chronic kidney diseases (Alport syndrome, IgA nephropathy, and hypertensive nephrosclerosis, respectively) receiving dupilumab for their concomitant severe AD. Results: Treatment with a standard dosage of dupilumab caused a relevant improvement of AD in all patients without any adverse events or worsening of renal function. In a patient with severe renal failure, the drug was effective and well tolerated without the need for any dose adjustments, also after the initiation of peritoneal dialytic treatment. Conclusion: Our case series suggests the use of dupilumab as an effective and safe treatment for AD patients suffering from renal diseases, although additional studies are required to confirm such preliminary findings. Full article

(This article belongs to the Special Issue Current Research on Dermatology: Pathology, Clinical Manifestation, Investigation and Therapy)

► Show Figures

Figure 1

Open AccessCase Report

Hereditary Hemorrhagic Telangiectasia Associating Neuropsychiatric Manifestations with a Significant Impact on Disease Management—Case Report and Literature Review

Violeta Claudia Bojincă

and

Aurelia Romila

Life 2022, 12(7), 1059; https://doi.org/10.3390/life12071059 - 15 Jul 2022

Viewed by 1330

Abstract

(1) Background: Genetic hereditary hemorrhagic telangiectasia (HHT) is clinically diagnosed. The clinical manifestations and lack of curative therapeutic interventions may lead to mental illnesses, mainly from the depression–anxiety spectrum. (2) Methods: We report the case of a 69-year-old patient diagnosed with HHT and associated psychiatric disorders; a comprehensive literature review was performed based on relevant keywords. (3) Results: Curaçao diagnostic criteria based the HHT diagnosis in our patient case at 63 years old around the surgical interventions for a basal cell carcinoma, after multiple episodes of epistaxis beginning in childhood, but with a long symptom-free period between 20 and 45 years of age. The anxiety–depressive disorder associated with nosocomephobia resulted in a delayed diagnosis and low adherence to medical monitoring. A comprehensive literature review revealed the scarcity of publications analyzing the impact of psychiatric disorders linked to this rare condition, frequently associating behavioral disengagement as a coping strategy, psychological distress, anxiety, depression, and hopelessness. (4) Conclusions: As patients with HHT face traumatic experiences from disease-related causes as well as recurring emergency hospital visits, active monitoring for mental illnesses and psychological support should be considered as part of the initial medical approach and throughout the continuum of care. Full article

(This article belongs to the Special Issue Current Research on Dermatology: Pathology, Clinical Manifestation, Investigation and Therapy)

► Show Figures

Figure 1

Journal Menu

Journal Browser

Special Issue "Current Research on Dermatology: Pathology, Clinical Manifestation, Investigation and Therapy"

Share This Special Issue

Special Issue Editor

Special Issue Information

Keywords

Published Papers (15 papers)

Research

Review

Other

Further Information

Guidelines

MDPI Initiatives

Follow MDPI