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Genes 2018, 9(10), 495; https://doi.org/10.3390/genes9100495

The Global Hepatitis B Virus Genotype Distribution Approximated from Available Genotyping Data

1
Institute of Virology, Technische Universität München/Helmholtz Zentrum München, Trogerstrasse 30, D-81675 München, Germany
2
Department of Epidemiology, Helmholtz Centre for Infection Research, D-38124 Braunschweig, Germany; Hannover Medical School, D-30625 Hannover, Germany
3
German Center for Infection Research (DZIF), Munich Partner Site
*
Author to whom correspondence should be addressed.
Received: 7 September 2018 / Revised: 2 October 2018 / Accepted: 10 October 2018 / Published: 15 October 2018
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Abstract

Hepatitis B virus (HBV) is divided into nine genotypes, A to I. Currently, it remains unclear how the individual genotypes contribute to the estimated 250 million chronic HBV infections. We performed a literature search on HBV genotyping data throughout the world. Over 900 publications were assessed and data were extracted from 213 records covering 125 countries. Using previously published HBV prevalence, and population data, we approximated the number of infections with each HBV genotype per country and the genotype distribution among global chronic HBV infections. We estimated that 96% of chronic HBV infections worldwide are caused by five of the nine genotypes: genotype C is most common (26%), followed by genotype D (22%), E (18%), A (17%) and B (14%). Genotypes F to I together cause less than 2% of global chronic HBV infections. Our work provides an up-to-date analysis of global HBV genotyping data and an initial approach to estimate how genotypes contribute to the global burden of chronic HBV infection. Results highlight the need to provide HBV cell culture and animal models that cover at least genotypes A to E and represent the vast majority of global HBV infections to test novel treatment strategies. View Full-Text
Keywords: Hepatitis B virus; chronic hepatitis B; genotype; sequencing; molecular epidemiology Hepatitis B virus; chronic hepatitis B; genotype; sequencing; molecular epidemiology
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Velkov, S.; Ott, J.J.; Protzer, U.; Michler, T. The Global Hepatitis B Virus Genotype Distribution Approximated from Available Genotyping Data. Genes 2018, 9, 495.

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